Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122700 - 122700

Published: July 4, 2024

Language: Английский

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Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: Oct. 21, 2024

Abstract Severe tissue defects present formidable challenges to human health, persisting as major contributors mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects, poses substantial hurdles existing regeneration strategies. However, emergence of nanobiotechnology has opened a new direction in immunomodulatory nanomedicine, providing encouraging prospects for and restoration. This review aims gather recent advances nanomedicine foster regeneration. We begin by elucidating distinctive features local microenvironment defective tissues its crucial role Subsequently, we explore design functional properties nanosystems. Finally, address clinical translation development, aiming propose potent approach enhance through synergistic modulation integration.

Language: Английский

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Engineered Enucleated Mesenchymal Stem Cells Regulating Immune Microenvironment and Promoting Wound Healing

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract Persistent excessive inflammation caused by neutrophil and macrophage dysfunction in the wound bed leads to refractory response during healing. However, previous studies using cytokines or drugs often suffer from short half‐lives limited targeting, resulting unsatisfactory therapeutic effects. Herein, enucleated mesenchymal stem cell is engineered aptamer bioorthogonal chemistry modify membrane mRNA loading cytoplasm as a novel delivery vector (Cargocyte) with accurate targeting sustained cytokine secretion. Cargocytes can successfully reduce NETosis nuclear chromatin protein DEK aptamers sustaining interleukin (IL)‐4 expression overcome challenges associated high cost half‐life of IL‐4 significantly prevent transition macrophages into M1 phenotype. Therapeutic effects have been demonstrated murine porcine models powerful potential improve immune microenvironments effectively. Overall, use cells system may be promising approach for

Language: Английский

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mRNA therapy: A new frontier in regenerative medicine

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Tissue regeneration has raised intensive attention due to its great significance in overcoming various diseases resulting from different injuries. Since the COVID‐19 pandemic, mRNA therapeutics have emerged as innovative strategies prevention and treatment of their unique advantages. Compared traditional regenerative strategies, therapy offers rapid translation into proteins with low production cost high modifiability. Herein, we discuss progress key processes therapy, focusing on therapeutic modification delivery carriers. The preclinical clinical studies for cardiac, lung, liver, kidney, locomotor system, skin lesions neurological disorders were summarized comprehensively. Developing reduce immunogenicity off‐target effects, well optimization system may accelerate pace translation.

Language: Английский

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Multi-functional dressing with curcumin displays anti-inflammatory, antioxidant, angiogenic, and collagen regeneration effects in diabetic wound healing

Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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Furan-Derived Lipid Nanoparticles for Transporting mRNA to the Central Nervous System

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(19), P. 16007 - 16017

Published: April 30, 2025

Delivery of mRNA (mRNA) to the central nervous system (CNS) remains a significant challenge. Herein, we design library furan-derived lipids and, our knowledge, for first time, leverage meningeal lymphatic vessels (MLVs) route achieve efficient delivery brain. These were engineered with different furan cores, functional groups, and tails. We found that tetrahydrofuran (THF)-derived lipid nanoparticles (LNPs) generally displayed exceptional compared their furan-based counterparts. Specifically, LNPs formulated four-acetal-tail mono-THF-derived F10T5 di-THF-derived F11T6 demonstrated significantly higher efficiency brain FDA-approved SM102 LNPs. The data revealed these bypassed blood-brain barrier (BBB) via pathway, traveling from deep cervical lymph nodes (dCLNs) meninges subsequently entering cells. Collectively, this work provides valuable insights into engineering exploring alternative approaches

Language: Английский

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Unlock the sustained therapeutic efficacy of mRNA

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113837 - 113837

Published: May 1, 2025

Language: Английский

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Comparative Analysis of RNAs’ Delivery Systems in diabetic wound healing: Mechanisms, Applications, and Future Prospects

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 174, P. 02006 - 02006

Published: Jan. 1, 2025

The role of RNA in the treatment diabetic foot has received increasing attention as therapy been used a variety ways. This article explores various delivery methods for different types RNA, with focus on their mechanisms, efficiency, and potential applications. Discussed encapsulation, adsorption, layer by assembly, covalent binding, targeting strategies involving MiRNA, SiRNA, mRNA, LncRNA. Analyze advantages disadvantages each method targeted release point out clinical applications wound.

Language: Английский

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Immune‐Vascular Synergy: A Photodynamic Hydrogel Activating ALDH2 to Combat Inflammation and Enhance Angiogenesis in Diabetic Wound Healing

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Infected diabetic wounds present serious therapeutic challenges, primarily due to persistent infections, impaired immune responses, and insufficient vascularization. Excessive secretion of neutrophil extracellular traps (NETs) is increasingly recognized as a key driver inflammation in wounds. Single‐cell sequencing analysis clinical specimens reveals deficiency aldehyde dehydrogenase 2 (ALDH2) within wound tissues, which plays critical role sustaining hindering vascular regeneration. Unlike conventional treatments that focus on either infection control or repair, photodynamic hydrogel with dual‐function strategy developed, uniquely integrating ALDH2 activation immune‐vascular modulation address these multifaceted challenges. The hydrogel‐mediated effectively reduces NET formation mitigates chronic inflammation, while promoting macrophage polarization from the pro‐inflammatory M1 phenotype reparative M2 phenotype. This transition fosters an anti‐inflammatory microenvironment not only facilitates tissue repair but also enhances angiogenesis by stimulating endothelial cell activity, improving vascularization at site. In contrast existing therapeutics, approach directly targets interplay between regulation regeneration, offering synergistic mechanism enhance healing outcomes. findings introduce synergy‐based strategy, emphasizing translational potential this technology for management.

Language: Английский

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Local delivery of siRNA using lipid-based nanocarriers with ROS-scavenging ability for accelerated chronic wound healing in diabetes

Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123411 - 123411

Published: May 13, 2025

Language: Английский

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