ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(9), P. 11172 - 11184
Published: Feb. 22, 2024
Lateral
flow
immunoassay
(LFIA)
has
been
widely
used
for
the
early
diagnosis
of
diseases.
However,
conventional
colorimetric
LFIA
possesses
limited
sensitivity,
and
single-mode
readout
signal
is
easily
affected
by
external
environment,
leading
to
insufficient
accuracy.
Herein,
multifunctional
Fe3O4@MoS2@Pt
nanotags
with
a
unique
"pompon
mum"-like
structure
were
triumphantly
prepared,
exhibiting
excellent
peroxidase
(POD)-like
activity,
photothermal
properties,
magnetic
separation
capability.
Furthermore,
establish
dual-mode
(dLFIA)
first
time,
enabling
catalytic
detection
severe
acute
respiratory
syndrome
coronavirus
2
nucleocapsid
protein
(SARS-CoV-2
NP)
influenza
A
(H1N1).
The
calculated
limits
(cLODs)
SARS-CoV-2
NP
H1N1
80
20
ng/mL
in
mode
10
8
mode,
respectively,
demonstrating
about
100
times
more
sensitive
than
commercial
colloidal
Au-LFIA
strips
(1
NP;
1
μg/mL
H1N1).
recovery
rates
dLFIA
simulated
nose
swab
samples
95.2–103.8%
coefficient
variance
2.3–10.1%.
These
results
indicated
that
proposed
platform
showed
great
potential
rapid
viruses.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 13, 2024
Abstract
Cascade
reactions
are
described
as
efficient
and
versatile
tools,
organized
catalytic
cascades
can
significantly
improve
the
efficiency
of
chemical
interworking
between
nanozymes.
They
have
attracted
great
interest
in
many
fields
such
chromogenic
detection,
biosensing,
tumor
diagnosis,
therapy.
However,
how
to
selectively
kill
cells
by
enzymatic
without
harming
normal
cells,
well
exploring
two
or
more
enzyme‐engineered
nanoreactors
for
cascading
reactions,
remain
challenges
field
targeted
specific
cancer
diagnostics
The
latest
research
advances
nanozyme‐catalyzed
cascade
processes
diagnosis
therapy
this
article.
Here,
various
sensing
strategies
summarized,
tumor‐specific
diagnostics.
Targeting
mechanisms
treatment
using
nanozymes
classified
analyzed,
“elements”
“dimensions”
nanozymes,
types,
designs
structure,
assembly
modes
highly
active
a
variety
new
targeting
based
on
reaction
Finally,
integrated
application
systems
tumor‐targeted
diagnostic
is
which
will
lay
foundation
design
rational,
efficient,
therapeutic
modalities
future.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 22, 2024
Single-atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)-mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single-atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi-enzyme
mimetic
MoCu
dual-atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme-like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near-infrared
II
bio-window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high-efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(6), P. 2071 - 2080
Published: Feb. 2, 2024
Ferroptosis
is
a
novel
type
of
nonapoptotic
programmed
cell
death
involving
the
accumulation
lipid
peroxidation
(LPO)
to
lethal
threshold.
Herein,
we
propose
tunable
zeolitic
imidazolate
framework
(ZIFs)-engineered
biodegradable
nanozymes
for
ferroptosis
mediated
by
both
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS).
l-Arginine
utilized
as
an
exogenous
nitric
oxide
donor
loaded
into
hollow
ZIFs@MnO2
artificial
nanozymes,
which
are
formed
etching
ZIFs
with
potassium
permanganate
simultaneously
generating
MnO2
shell
in
situ.
The
constructed
multienzyme-like
activities
including
peroxidase,
oxidase,
catalase
can
release
satisfactory
ROS
RNS
through
cascade
reaction,
consequently
promoting
LPO.
Furthermore,
it
improve
efficiency
three-step
strategy
glutathione
(GSH)
depletion;
that
is,
outer
layer
consumes
GSH
under
slightly
acidic
conditions
downregulates
SLC7A11
reductase,
thus
directly
inhibiting
biosynthesis
indirectly
preventing
regeneration.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(9), P. 11172 - 11184
Published: Feb. 22, 2024
Lateral
flow
immunoassay
(LFIA)
has
been
widely
used
for
the
early
diagnosis
of
diseases.
However,
conventional
colorimetric
LFIA
possesses
limited
sensitivity,
and
single-mode
readout
signal
is
easily
affected
by
external
environment,
leading
to
insufficient
accuracy.
Herein,
multifunctional
Fe3O4@MoS2@Pt
nanotags
with
a
unique
"pompon
mum"-like
structure
were
triumphantly
prepared,
exhibiting
excellent
peroxidase
(POD)-like
activity,
photothermal
properties,
magnetic
separation
capability.
Furthermore,
establish
dual-mode
(dLFIA)
first
time,
enabling
catalytic
detection
severe
acute
respiratory
syndrome
coronavirus
2
nucleocapsid
protein
(SARS-CoV-2
NP)
influenza
A
(H1N1).
The
calculated
limits
(cLODs)
SARS-CoV-2
NP
H1N1
80
20
ng/mL
in
mode
10
8
mode,
respectively,
demonstrating
about
100
times
more
sensitive
than
commercial
colloidal
Au-LFIA
strips
(1
NP;
1
μg/mL
H1N1).
recovery
rates
dLFIA
simulated
nose
swab
samples
95.2–103.8%
coefficient
variance
2.3–10.1%.
These
results
indicated
that
proposed
platform
showed
great
potential
rapid
viruses.
