International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135353 - 135353
Published: Sept. 7, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Light serves as an excellent external stimulus due to its high spatial and temporal resolution. The use of light regulate biological processes has evolved into a vibrant field over the past decade. Employing on chemical substances such bioactive molecules drug delivery systems offers promising therapeutic approach achieve precise control processes. In this review, we provide overview advancements in optochemical technologies for controlling (photopharmacology) (photoresponsive delivery), with emphasis their relationship biomedical applications. Gaining deeper understanding underlying mechanisms emerging research will facilitate development optochemically controlled photoresponsive systems, further enhancing
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)
Published: Feb. 7, 2024
Abstract The integrative use of light and nanoassemblies has made a profound impact in the biomedical field for diagnosis, drug delivery, phototherapy. Recent advances development light‐responsive showcase their capabilities facilitating targeted diagnosis therapy with minimal invasiveness, shaping future personalized medicine. In this work, fundamental differences between types applications, application are described, biosafety profile is overviewed discussed, translational challenges potential clinical outlook emerging outlined.
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673
Published: April 3, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(13)
Published: Dec. 21, 2023
Abstract The development of environment‐friendly bacteriostats in humid atmosphere is designated as a crucial step pointing to sustainable antibiotic‐free alterative. Thanks the excellent biosafety and intrinsic bacteriostatic attributes, bioactive phytochemical formulations become fascinating substitute for traditional antibiotics; yet, it remains challenge deliver them toward moisture‐activated application due unclear release mechanism behavior. Benefitting from “green” metal–organic frameworks (MOFs) evolved natural γ ‐cyclodextrin ( ‐CD) potassium ion (K + ), an intelligent formulation developed, which featured by grafting vanillin (a specific extracted Rutaceae vanilla bean) into microporous structure MOFs via ligand implantation mechanism. According molecular simulation docking, dominant pattern host–guest characteristic H‐bond with length 1.9 Å, beneficial sterling adsorption capacity. Nevertheless, under moisture exposure, intermolecular disrupted destroy bacterial membrane structure, accelerate protein decomposition, especially inhibit virulence gene transcription cfa Escherichia coli sea Staphylococcus aureus , directing upgrade insights potency phytochemicals high‐humidity circumstance.
Language: Английский
Citations
9
Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101881 - 101881
Published: May 24, 2023
Language: Английский
Citations
8
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(51), P. 18731 - 18738
Published: Dec. 14, 2023
The engineering of catalytic hybridization DNA circuits represents versatile ways to orchestrate a complex flux molecular information at the nanoscale, with potential applications in DNA-encoded biosensing, drug discovery, and therapeutics. However, diffusive escape intermediates unintentional binding interactions remain an unsolved challenge. Herein, we developed compact, yet efficient, self-regulatory assembly circuit (SAC) for achieving robust microRNA (miRNA) imaging live cells through DNA-templated guaranteed hybridization. By integrating toehold strand preblocked palindromic fragment stem domain, proposed miniature SAC system allows reactant-to-template-controlled proximal hybridization, thus facilitating bidirectional-sustained localization-intensified signal amplification without undesired crosstalk. With condensed components low reactant complexity, amplifier realized high-contrast intracellular miRNA imaging. We anticipate that this simple template-controlled design can enrich clinical diagnosis prognosis toolbox.
Language: Английский
Citations
8
Nanoscale Advances, Journal Year: 2023, Volume and Issue: 6(2), P. 386 - 401
Published: Dec. 19, 2023
DNA nanotechnology has significantly progressed in the last four decades, creating nucleic acid structures widely used various biological applications. The structural flexibility, programmability, and multiform customization of DNA-based nanostructures make them ideal for all sizes shapes multivalent drug delivery systems. Since then, advanced significantly, numerous have been biology other scientific disciplines. Despite progress made nanotechnology, challenges still need to be addressed before can interfaces. We open door upcoming uses nanoparticles by tackling these issues looking into new avenues. historical development nanomaterials thoroughly examined this review, along with underlying theoretical underpinnings, a summary their applications fields, an examination current roadblocks potential future directions.
Language: Английский
Citations
8
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(18), P. 21917 - 21928
Published: April 27, 2023
The in situ detection of low-content cancer biomarkers by an endogenous activator instead exogenous initiator vitro remains a great challenge, leaving gap the development tumor-specific nanosensor with protease-activatable manner. Herein, we proposed (PA-NS) guided peptide nucleic acid-peptide-DNA copolymers to realize AND-gated and dual-model sensing miRNA-21 (miR-21) combining electrochemical optical imaging living tumor cells, without additional introduction or nanomaterials. Moreover, PA-NS can only be activated "dual keys" (overexpressed miR-21 cathepsin B protease cells) simultaneously, which enables effective improvement tumor-to-healthy cells ratio. fluorescence intensity measured single was ∼3.5-fold higher than that healthy response decreased ∼30% presence target miRNA. Furthermore, studies on regulation activity fluctuation under external stimulation have contributed our understanding biological processes drug screenings underlying disease development. This specific protease-mediated manner for miRNA guarantees excellent tumor-selective capability, offers new opportunities study cell heterogeneity provides more reliable fundamentals diagnosis treatment down single-cell level.
Language: Английский
Citations
7
Materials & Design, Journal Year: 2024, Volume and Issue: 245, P. 113270 - 113270
Published: Aug. 27, 2024
Language: Английский
Citations
2
View, Journal Year: 2023, Volume and Issue: 5(1)
Published: Dec. 1, 2023
Abstract DNA programming, which is based on the principle of base complementary pairing and Boolean operations, exhibits organizational structures algorithms similar to those observed in machine language. Consequently, practical implementation logic programming can be achieved through utilization techniques, enabling discrimination output generation. In recent years, has witnessed a convergence with disciplines, such as life sciences, medicine, other interdisciplinary areas, thereby giving rise an advanced research system that yields valuable insights. This development paved way for multidisciplinary cutting‐edge research. Furthermore, successful transition from conceptualization been accomplished. review summarizes advances within biomedical fields, specifically emphasizing execution constructs. The benefits obstacles associated adoption areas are also highlighted.
Language: Английский
Citations
6