Harnessing chemical functionality of xylan hemicellulose towards carbohydrate polymer-based pH/magnetic dual-responsive nanocomposite hydrogel for drug delivery

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122461 - 122461

Published: July 3, 2024

This study reports a pH/magnetic dual-responsive hemicellulose-based nanocomposite hydrogel with nearly 100 % carbohydrate polymer-based and biodegradable polymer compositions for drug delivery. We synthesized pure Fe

Language: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

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Precise Preparation of Size-Uniform Two-Dimensional Platelet Micelles Through Crystallization-Assisted Rapid Microphase Separation Using All-Bottlebrush-Type Block Copolymers with Crystalline Side Chains

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Polymer nanoparticles with low curvature, especially two-dimensional (2D) soft materials, are rich in functions and outstanding properties have received extensive attention. Crystallization-driven self-assembly (CDSA) of linear semicrystalline block copolymers is currently a common method constructing 2D platelets uniform size. Although accompanied by high controllability, this CDSA usually inevitably requires longer aging time lower assembly concentration, limiting the large-scale preparation nanoaggregates. In study, series all-bottlebrush-type copolymers, poly(octadecyl acrylate)-block-poly(oligoethylene glycol methyl ether methacrylate)s prepared living polymerization. Driven synergistic crystallization crystalline side chains rapid microphase separation bottlebrush topology, these polymers can assemble into circular platelet micelles few minutes, without being affected concentration. process, epitaxial growth molecules proceeds rigid cylindrical molecular conformation at micelle sites eventually provides sandwich-type according to head-to-head stacking mode. This explained as "crystallization-assisted separation" mechanism. The structures solvent temperature, size which shows dependence on temperature below melting point block, be used precisely control morphology platelets. study establishes an efficient prepare polymer nanosoft promising candidates for further development, preparation, application various nanomaterials.

Language: Английский

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Conformation and thermoresponsiveness of a graft copolymer at poly-2-isopropyl-2-oxazoline side chains and an aromatic polyester main chain with a short alkylene spacer

Journal of Polymer Research, Journal Year: 2025, Volume and Issue: 32(2)

Published: Feb. 1, 2025

Language: Английский

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Ammonium-Containing Methacrylic Polymer Brushes with Adjustable Hydrophilicity: Synthesis and Properties in Aqueous Solutions

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1200 - 1200

Published: April 27, 2025

Reversible addition–fragmentation chain-transfer (RAFT) polymerization was used to synthesize novel thermoresponsive cationic molecular brushes with high yields—namely of copolymers methoxyoligo(ethylene glycol) methacrylate, alkoxyoligo(ethylene and N-methacryloylaminopropyl-N,N-dimethyl-N-propylammonium bromide. Controlled yielded polymers a weight dispersity ≤1.3 conversions exceeding 80%. The influence the brushes’ composition on their solubility in water organic solvents, interfacial tension at water–oil interface, aggregation behavior aqueous solutions investigated. For first time, we report design combining an antibacterial potential tunable hydrophilic–hydrophobic properties, enabling highly precise control over LCST (17–68 °C) through tuning. solubilization capacity hydrophobic compounds brush micelles increased comonomer content. These exhibited activity, significantly reducing tension, critical micelle concentrations (CMCs) 3–10 mg/L. It shown that amphiphilic properties can be easily tuned desired direction by varying content units. obtained data indicate as micellar nanocarriers for controlled drug delivery.

Language: Английский

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Photonic Pigments of Polystyrene-block-Polyvinylpyrrolidone Bottlebrush Block Copolymers via Sustainable Organized Spontaneous Emulsification

ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(5), P. 495 - 501

Published: April 12, 2024

Prior studies on photonic pigments of amphiphilic bottlebrush block copolymers (BBCPs) through an organized spontaneous emulsification (OSE) mechanism have been limited to using polyethylene glycol (PEG) as the hydrophilic side chains and toluene organic phase. Herein, a family polystyrene-block-polyvinylpyrrolidone (PS-b-PVP) BBCPs are synthesized with PVP block. Biocompatible sustainable anisole is employed for dissolving obtained followed by solutions in water. Subsequent evaporation oil-in-water emulsion droplets triggers OSE mechanism, producing thermodynamically stable water-in-oil-in-water (w/o/w) multiple emulsions uniform closely packed internal droplet arrays assembly at w/o interface. Upon solidification, homogeneous porous structures formed within microparticles that exhibit visible structural colors. The pore diameter widely tunable (150∼314 nm) changing degree polymerization BBCP (69∼110), resulting colors across whole spectrum. This work demonstrates useful knowledge can be generally used fabrication ordered materials functional groups, not only applications, but also offers potential platform catalysis, sensing, separation, encapsulation, etc.

Language: Английский

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Bottlebrush Polymers: From Synthesis to Properties and Applications

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Abstract Bottlebrush polymers (BBPs) have emerged as a special class of macromolecules composed linear backbone the main chain with densely grafted polymeric side chains. BBPs present many unique properties, such low entanglement, high extension backbone, and extremely plateau shear moduli relative to their analogs due distinct conformational topological characteristics. This review summarizes recent significant advances BBPs, from synthetic methods versatile properties applications in areas super‐soft elastomers, photonic crystals, self‐assembly, friction, biomimetic tissues, bio‐interfacial interactions enhance cell penetration anti‐fouling performance, drug delivery, other emerging (polymer electrolyte, catalyst support, covalent adaptable networks). Meanwhile, molecular dynamic simulations are discussed tool disclose relationship between structures properties. will comprehensively summarize studies on point out direction give prediction application trend, comment future BBPs.

Language: Английский

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Nonequilibrium Solution-Based Assemblies from Bottlebrush Block Copolymers for Drug Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

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pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(6), P. 459 - 481

Published: Jan. 15, 2024

Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry x-ray diffraction assessed EGCG encapsulation. Results: The showed stability bioavailability the gastrointestinal tract, efficiently encapsulating releasing over 93% pH 7.2. They enhanced cytotoxicity against HT-29 cells demonstrated antibacterial properties, increasing apoptosis cell cycle arrest. Conclusion: study underscores potential enhancing therapy, aiming minimize side effects improve therapeutic outcomes.

Language: Английский

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Applications of surface‐grafted polymer brushes with various architectures

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(4)

Published: April 1, 2024

Abstract Surface‐grafted polymer brushes (PBs) are a versatile class of thin coatings that exhibit unique properties due to their densely grafted chains. PBs typically formed through surface‐initiated polymerizations, particularly reversible deactivation radical and macromolecules adopt extended conformations differentiate them from classical films. This review explores various applications PBs, emphasizing macromolecular ordering, dynamic conformational changes, anisotropic properties, so forth. The growing interest in utilizing for functional is discussed fields, including electronic, biological, environmental applications. In electronic applications, find relevance photovoltaics, energy storage devices, organic light‐emitting diodes, electronics, showcasing potential advancing technologies. biological they contribute the formation antifouling antibacterial coatings, as well superior lubrication cellular adhesion, making valuable biomedical settings. Other include biosensors, bioimaging systems, drug delivery highlighting significant contributions medical advancements. Additionally, play an important role such water wastewater treatment. A variety recent examples surface‐grafted presented, providing insights into architectures success demanding areas science technology.

Language: Английский

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