ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(47), P. 64410 - 64423
Published: Nov. 12, 2024
Carbon-nitride-based
(CN-based)
materials
have
shown
great
potential
in
combination
therapy
recent
years.
Due
to
their
outstanding
biocompatibility,
ease
of
modification,
and
adjustable
band-gap
position,
CN-based
can
be
applied
as
photosensitizers
photodynamic
(PDT)
light-driven
water-splitting
catalysts
gas
therapy.
After
doping
with
other
elements,
the
photocatalytic
performance
will
enhanced,
more
interesting
functions
obtained.
In
addition,
large
specific
surface
area
also
promotes
drug
carriers
combined
therapeutic
modalities
achieve
This
Review
analyzes
summarizes
latest
research
on
therapies,
such
PDT
photothermal
(PTT),
sonodynamic
(SDT),
therapy,
gene
PDT,
bioimaging-guided
particular,
applications
are
summarized
for
first
time.
Finally,
current
challenges
faced
by
further
discussed.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(22), P. 15251 - 15263
Published: May 23, 2024
Glioblastoma
(GBM)
poses
a
significant
therapeutic
challenge
due
to
its
invasive
nature
and
limited
drug
penetration
through
the
blood–brain
barrier
(BBB).
In
response,
here
we
present
an
innovative
biomimetic
approach
involving
development
of
genetically
engineered
exosome
nanocatalysts
(Mn@Bi2Se3@RGE-Exos)
for
efficient
GBM
therapy
via
improving
BBB
enzyme-like
catalytic
activities.
Interestingly,
photothermally
activatable
multiple
reactivity
is
observed
in
such
nanosystem.
Upon
NIR-II
light
irradiation,
Mn@Bi2Se3@RGE-Exos
are
capable
converting
hydrogen
peroxide
into
hydroxyl
radicals,
oxygen,
superoxide
providing
peroxidase
(POD),
oxidase
(OXD),
catalase
(CAT)-like
nanocatalytic
cascade.
This
consequently
leads
strong
oxidative
stresses
damage
cells.
vitro,
vivo,
proteomic
analysis
further
reveal
potential
disruption
cellular
homeostasis,
enhancement
immunological
induction
cancer
cell
ferroptosis,
showcasing
great
promise
anticancer
efficacy
against
with
favorable
biosafety
profile.
Overall,
success
this
study
provides
feasible
strategy
future
design
clinical
stimuli-responsive
medicine,
especially
context
challenging
brain
cancers
like
GBM.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2650 - 2669
Published: Jan. 1, 2024
Combining
phototherapies,
particularly
PDT
and
PTT,
with
immunotherapy
synergistically
stimulates
immune
responses,
offering
promising
strategies
for
effective
cancer
treatment
prevention
of
recurrence.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 3, 2024
Compared
with
conventional
therapies,
photoimmunotherapy
offers
precise
targeted
cancer
treatment
minimal
damage
to
healthy
tissues
and
reduced
side
effects,
but
its
efficacy
may
be
limited
by
shallow
light
penetration
the
potential
for
tumor
resistance.
Here,
an
acceptor-donor-acceptor
(A-D-A)-structured
nanoaggregate
is
developed
dual
phototherapy,
including
photodynamic
therapy
(PDT)
photothermal
(PTT),
triggered
single
near-infrared
(NIR)
light.
Benefiting
from
strong
intramolecular
charge
transfer
(ICT),
A-D-A-structured
nanoaggregates
exhibit
broad
absorption
extending
NIR
region
effectively
suppressed
fluorescence,
which
enables
deep
efficient
conversion
(η
=
67.94%).
A
suitable
HOMO-LUMO
distribution
facilitates
sufficient
intersystem
crossing
(ISC)
convert
ground-state
oxygen
(
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(8), P. 9816 - 9825
Published: Feb. 21, 2024
Imaging-guided
photodynamic
therapy
(PDT)
holds
great
potential
for
tumor
therapy.
However,
achieving
the
synergistic
enhancement
of
reactive
oxygen
species
(ROS)
generation
efficiency
and
fluorescence
emission
photosensitizers
(PSs)
remains
a
challenge,
resulting
in
suboptimal
image
guidance
theranostic
efficacy.
The
hypoxic
microenvironment
also
hinders
efficacy
PDT.
Herein,
we
propose
"two-stage
rocket-propelled"
photosensitive
system
cell
ablation.
This
utilizes
MitoS,
mitochondria-targeted
PS,
to
ablate
cells.
Importantly,
MitoS
can
react
with
HClO
generate
more
efficient
MitoSO,
significantly
improved
quantum
yield.
Both
MitoSO
exhibit
less
O
The
elevated
glutathione
(GSH)
level
and
hypoxia
in
tumor
cells
are
two
key
obstacles
to
realizing
the
high
performance
of
phototherapy.
Herein,
electron-donating
rotors
introduced
wings
electron-withdrawing
pyrrolopyrrole
cyanine
(PPCy)
form
donor-acceptor-donor
structure
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(3)
Published: Jan. 27, 2025
Photodynamic
therapy
(PDT)
is
a
noninvasive
cancer
treatment
that
works
by
using
light
to
stimulate
the
production
of
excessive
cytotoxic
reactive
oxygen
species
(ROS),
which
effectively
eliminates
tumor
cells.
However,
therapeutic
effects
PDT
are
often
limited
hypoxia,
prevents
effective
cell
elimination.
The
(O2)
consumption
during
can
further
exacerbate
leading
post-treatment
adverse
events.
This
review
aims
explore
potential
cuproptosis,
recently
discovered
copper-dependent
form
programmed
death,
enhance
anticancer
PDT.
Cuproptosis
highly
dependent
on
mitochondrial
respiration,
specifically
tricarboxylic
acid
(TCA)
cycle,
and
increase
O2
ROS
levels
or
decrease
glutathione
(GSH)
levels,
thereby
improving
outcomes.
discusses
latest
research
advancements
in
field,
detailing
mechanisms
regulate
cuproptosis
It
also
explores
how
nanoparticle
(NP)-based
strategies
be
used
exploit
synergistic
between
article
examines
prospects
activity
guided
nanodelivery
systems,
could
overcome
challenges
associated
with
hypoxia
treatment.
combination
PDT,
facilitated
NP-based
delivery
presents
promising
approach
effectiveness
therapy.
concludes
discussing
future
directions
for
this
therapy,
highlighting
need
investigation
into
optimization
improve
outcomes
