ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(47), P. 64410 - 64423
Published: Nov. 12, 2024
Carbon-nitride-based
(CN-based)
materials
have
shown
great
potential
in
combination
therapy
recent
years.
Due
to
their
outstanding
biocompatibility,
ease
of
modification,
and
adjustable
band-gap
position,
CN-based
can
be
applied
as
photosensitizers
photodynamic
(PDT)
light-driven
water-splitting
catalysts
gas
therapy.
After
doping
with
other
elements,
the
photocatalytic
performance
will
enhanced,
more
interesting
functions
obtained.
In
addition,
large
specific
surface
area
also
promotes
drug
carriers
combined
therapeutic
modalities
achieve
This
Review
analyzes
summarizes
latest
research
on
therapies,
such
PDT
photothermal
(PTT),
sonodynamic
(SDT),
therapy,
gene
PDT,
bioimaging-guided
particular,
applications
are
summarized
for
first
time.
Finally,
current
challenges
faced
by
further
discussed.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 10, 2024
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
is
a
promising
treatment
approach
for
multidrug
resistant
infections.
PDT/PTT
combination
can
more
efficiently
eliminate
pathogens
without
drug
resistance.
The
key
to
improve
the
efficacy
of
photochemotherapy
utilization
efficiency
non-radiation
energy
phototherapy
agents.
Herein,
facile
molecule
(SCy-Le)
with
enhancement
non-radiative
transfer
designed
by
an
acid
stimulation
under
single
laser.
Introduction
protonated
receptor
into
SCy-Le
results
in
distorted
intramolecular
charge
infected
acidic
microenvironment,
pH
≈
5.5,
which
turn,
enhances
light
capture,
reduces
singlet-triplet
transition
energies
(ΔE
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 25, 2024
Abstract
Bacterial
therapy
is
recognized
as
a
cost‐effective
treatment
for
several
diseases.
However,
its
development
hindered
by
limited
functionality,
weak
inherent
therapeutic
effects,
and
vulnerability
to
harsh
microenvironmental
conditions,
leading
suboptimal
activity.
Enhancing
bacterial
activity
outcomes
emerges
pivotal
challenge.
Nanozymes
have
garnered
significant
attention
due
their
enzyme‐mimic
activities
high
stability.
They
enable
bacteria
mimic
the
functions
of
gene‐edited
expressing
same
functional
enzymes,
thereby
improving
efficacy.
This
review
delineates
mechanisms
nanozymes,
followed
summary
strategies
preparing
bacteria/nanozyme
composites.
Additionally,
synergistic
effects
such
composites
in
biomedical
applications
gastrointestinal
diseases
tumors
are
highlighted.
Finally,
challenges
discussed
propose
potential
solutions.
study
aims
provide
valuable
insights
offer
theoretical
guidance
advancement
nanomaterial‐assisted
therapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 24, 2024
In
the
context
of
an
increasingly
escalating
antibiotics
crisis,
phototherapy
has
emerged
as
a
promising
therapeutic
approach
due
to
its
inherent
advantages,
including
high
selectivity,
noninvasiveness,
and
low
drug
resistance.
Photothermal
therapy
(PTT)
photodynamic
(PDT)
are
two
complementary
phototherapies
albeit
with
limitations,
noted
challenges
in
achieving
precise
heat
confinement
associated
risk
off-target
damage
for
PTT,
while
constraints
hypoxic
microenvironment
prevalent
biofilms
faced
by
PDT.
Herein,
we
have
designed
supramolecular
nanoformulation
that
leverages
complexation-induced
quenching
guanidinium-modified
calix[5]arene
grafted
fluorocarbon
chains
(GC5AF
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(29), P. 7113 - 7121
Published: Jan. 1, 2024
The
clinical
application
of
photodynamic
therapy
(PDT)
has
some
limitations
including
poor
tumor
targeting
properties,
a
high
reductive
microenvironment,
and
inefficient
activation
single
cell
death
machinery.
We
herein
report
pH-sensitive
polymeric
nanomodulators
(NBS-PDMC
NPs)
for
ferroptosis-enhanced
therapy.
NBS-PDMC
NPs
were
constructed
using
positively
charged
type-I
photosensitizer
(NBS)
coordinated
with
demethylcantharidin
(DMC)-decorated
block
copolymer
via
electrostatic
interactions.
had
negative
surface
charge,
which
ensures
their
stability
in
bloodstream
circulation,
while
exposure
to
lysosomal
acidic
environments
reverses
charge
positive
penetration
the
release
DMC
NBS.
Under
NIR
light
irradiation,
NBS
generated
ROS
induce
damage;
meantime,
inhibited
expression
GPX4
protein
cells
promoted
ferroptosis
cells.
This
polymer
design
concept
provides
novel
insights
into
smart
drug
delivery
combinational
action
amplify
antitumor
effect.
