Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(18), P. 4275 - 4310
Published: Jan. 1, 2024
This
comprehensive
review
systematically
summarizes
the
intrinsic
mechanism
of
different
metal
ion
(such
as
Fe
3+
/Fe
2+
,
Cu
/Cu
+
Ca
Zn
Mn
Na
/K
and
Mg
)-mediated
interference
therapies
their
research
progress
in
cancer
treatment.
Biomaterials,
Journal Year:
2025,
Volume and Issue:
317, P. 123085 - 123085
Published: Jan. 5, 2025
T
cell
therapy
for
solid
tumors
faces
significant
challenges
due
to
the
immune
off-target
attack
caused
by
loss
of
tumor
surface
antigens
and
inactivation
in
acidic
microenvironment
(TME).
Herein,
we
developed
a
bifunctional
immunomodulator
(MO@NAL)
loading
ovalbumin
(OVA;
model
antigen)
mRNA
(mOVA)
onto
lysozyme-coated
layered
double
hydroxide
nano-aluminum
adjuvant
(NA).
The
NA's
inherent
alkalinity
effectively
neutralizes
excess
acid
within
TME
suppresses
regulatory
cells,
creating
favorable
enhance
cytotoxic
infiltration
activation
tumors.
Particularly,
once
internalization
MO@NAL
efficiently
tags
with
OVA
through
carried
mOVA,
providing
targets
recruiting
directing
antigen-specific
cells
destroy
cells.
In
mice
pre-vaccinated
vaccine,
intratumoral
administration
rapidly
awakens
OVA-specific
memory,
inhibiting
progression
colon
melanoma
at
both
early
advanced
stages.
non-pre-vaccinated
mice,
combining
therapeutic
vaccine
or
adoptive
transfusion
similarly
achieves
robust
suppression.
These
findings
thus
underscore
potential
as
an
effective
safe
enhancing
responses
timely
intervention
progression.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(45)
Published: Nov. 8, 2024
PANoptosis
has
recently
emerged
as
a
potential
approach
to
improve
the
immune
microenvironment.
However,
current
methods
for
inducing
are
limited.
Herein,
through
biological
screening,
rational
use
of
nutrient
metal
ions
Cu
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Higher
and
richer
nutrient
requirements
are
typical
features
that
distinguish
tumor
cells
from
AU:
cells,
ensuring
adequate
substrates
energy
sources
for
cell
proliferation
migration.
Therefore,
deprivation
strategies
based
on
targeted
technologies
can
induce
impaired
viability
in
which
more
sensitive
than
normal
cells.
In
this
review,
nutrients
required
by
related
metabolic
pathways
introduced,
anti-tumor
developed
to
target
described.
addition
the
nutritional
characteristics
of
other
microenvironment
(including
macrophages,
neutrophils,
natural
killer
T
cancer-associated
fibroblasts)
new
also
summarized.
conclusion,
recent
advances
targeting
blockade
reviewed,
challenges
prospects
these
discussed,
theoretical
significance
optimizing
clinical
application
nutrition
strategies.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Cancer
immunotherapy,
which
leverages
the
body's
immune
system
to
combat
cancer,
offers
promise
of
lower
toxicity
and
higher
therapeutic
efficacy
compared
conventional
treatments.
However,
current
immunotherapeutic
approaches
face
significant
challenges
including
variable
patient
response,
immune‐related
adverse
events,
high
costs,
underscoring
urgent
need
for
innovative
strategies.
Metal‐based
nanomaterials
have
emerged
as
a
promising
avenue
in
cancer
immunotherapy
due
their
unique
physicochemical
properties
immune‐regulating
capabilities.
Despite
potential,
concerns
about
toxicity,
incomplete
understanding
modulation
mechanisms,
early‐stage
design
strategies
hinder
clinical
translation.
This
review
summarizes
recent
advancements
metal‐based
elucidates
mechanisms
by
they
enhance
antitumor
immunity
responses,
explores
potential
synergistic
effects
combining
multiple
metals.
We
also
discuss
key
future
perspectives
application,
aiming
provide
theoretical
foundation
development
immunotherapies
promote
broader
application
treatment.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(6), P. 921 - 943
Published: June 2, 2024
Introduction
This
review
explores
the
innovative
intersection
of
ferroptosis,
a
form
iron-dependent
cell
death,
with
cancer
immunotherapy.
Traditional
treatments
face
limitations
in
efficacy
and
specificity.
Ferroptosis
as
new
paradigm
biology,
targets
metabolic
peculiarities
cells
may
potentially
overcome
such
limitations,
enhancing
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(17), P. 21072 - 21082
Published: Aug. 20, 2024
Sonodynamic
therapy
(SDT)
has
demonstrated
considerable
potential
in
its
noninvasive
approach
and
ability
to
target
tumors
located
deep
within
brain
tissues
(>10
cm).
However,
the
effectiveness
of
this
technique
is
hindered
by
tumor
hypoxia
(2%
O2),
abundance
reactive
oxygen
species
(ROS)
scavenger
glutathione
(GSH),
limited
ROS
generation
capacity
sonosensitizer.
In
light
these
limitations,
a
cascade
nanozyme
comprising
platinum
(Pt)-coated
porphyrin
metal–organic
frameworks
(PCN-224(Fe))
modified
with
COOH-PEG
was
developed
[Pt/PCN-224(Fe)/PEG,
labeled
as
PFMP
nanozyme]
enhance
toxicity
ROS.
This
emulates
catalytic
function
Pt
decomposition
hydrogen
peroxide
(H2O2)
into
O2
for
purpose
alleviating
hypoxia.
Additionally,
it
replicates
peroxidase
(GPX)
utilizing
iron
(Fe3+)
reduce
overexpression
GSH.
These
two
mechanisms
act
concert
amplify
They
achieve
enhancing
production
impairing
GSH
scavenge
ROS,
thereby
synergistically
potentiating
vitro
vivo
studies
have
evidence
efficient
generation,
resulting
significant
6-fold
reduction
volume
compared
control
groups
achieving
an
impressive
80%
survival
rate
30
days
after
treatment.
