Liquid exfoliation of molybdenum metallenes for non-inflammatory photothermal therapy of tumors DOI
Chenxin Lu,

Xiang Huang,

Zhaoying Jin

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(23), P. 5690 - 5698

Published: Jan. 1, 2024

We report a Mo metallene with excellent photothermal and antioxidant properties for non-inflammatory therapy.

Language: Английский

Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment DOI
Yutang Li, Yandong Wang, Zhao Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

Citations

9

Artificially Tagging Tumors with Nano-Aluminum Adjuvant-Tethered Antigen mRNA Recruits and Activates Antigen-Specific Cytotoxic T Cells for Enhanced Cancer Immunotherapy DOI Creative Commons
Lingxiao Zhang, Jie Bai,

Aining Shen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123085 - 123085

Published: Jan. 5, 2025

T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by loss of tumor surface antigens and inactivation in acidic microenvironment (TME). Herein, we developed a bifunctional immunomodulator (MO@NAL) loading ovalbumin (OVA; model antigen) mRNA (mOVA) onto lysozyme-coated layered double hydroxide nano-aluminum adjuvant (NA). The NA's inherent alkalinity effectively neutralizes excess acid within TME suppresses regulatory cells, creating favorable enhance cytotoxic infiltration activation tumors. Particularly, once internalization MO@NAL efficiently tags with OVA through carried mOVA, providing targets recruiting directing antigen-specific cells destroy cells. In mice pre-vaccinated vaccine, intratumoral administration rapidly awakens OVA-specific memory, inhibiting progression colon melanoma at both early advanced stages. non-pre-vaccinated mice, combining therapeutic vaccine or adoptive transfusion similarly achieves robust suppression. These findings thus underscore potential as an effective safe enhancing responses timely intervention progression.

Language: Английский

Citations

1

Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective DOI
Zifan Pei,

Longxiao Li,

Nailin Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969

Published: June 10, 2024

Language: Английский

Citations

8

Engineered manganese-BODIPY coordinated nanoadjuvants for enhanced NIR-II photo-metalloimmunotherapy DOI
Yushi Zhang, Xuya Yu, Lizhu Luo

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1115 - 1129

Published: Nov. 9, 2024

Language: Английский

Citations

7

Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy DOI Creative Commons

Guanghui Hou,

Y.‐J. Chen,

Huali Lei

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(45)

Published: Nov. 8, 2024

PANoptosis has recently emerged as a potential approach to improve the immune microenvironment. However, current methods for inducing are limited. Herein, through biological screening, rational use of nutrient metal ions Cu

Language: Английский

Citations

6

Metal-based nanocomposites for immunotherapy of osteosarcoma DOI

Puhua Hao,

Lulu Yang, Yichen Yan

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)

Published: Oct. 23, 2024

Language: Английский

Citations

4

Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities DOI Open Access
Jinsheng Shi, Wei Han, Jie Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.

Language: Английский

Citations

0

Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy DOI Creative Commons

Xing Sun,

Xican Xu,

Fengying Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

Citations

0

Regulation of ferroptosis by nanotechnology for enhanced cancer immunotherapy DOI
Haohan Zhou, Yiyun Cheng,

Quan Huang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(6), P. 921 - 943

Published: June 2, 2024

Introduction This review explores the innovative intersection of ferroptosis, a form iron-dependent cell death, with cancer immunotherapy. Traditional treatments face limitations in efficacy and specificity. Ferroptosis as new paradigm biology, targets metabolic peculiarities cells may potentially overcome such limitations, enhancing

Language: Английский

Citations

3

Cascade Nanozyme Comprising Pt-Coated Porphyrin Metal–Organic Frameworks Boosting Reactive Oxygen Species Generation for Sonodynamic Theranostics of a Tumor DOI
Ming Qian, Liang Gong, Jia Tao

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 21072 - 21082

Published: Aug. 20, 2024

Sonodynamic therapy (SDT) has demonstrated considerable potential in its noninvasive approach and ability to target tumors located deep within brain tissues (>10 cm). However, the effectiveness of this technique is hindered by tumor hypoxia (2% O2), abundance reactive oxygen species (ROS) scavenger glutathione (GSH), limited ROS generation capacity sonosensitizer. In light these limitations, a cascade nanozyme comprising platinum (Pt)-coated porphyrin metal–organic frameworks (PCN-224(Fe)) modified with COOH-PEG was developed [Pt/PCN-224(Fe)/PEG, labeled as PFMP nanozyme] enhance toxicity ROS. This emulates catalytic function Pt decomposition hydrogen peroxide (H2O2) into O2 for purpose alleviating hypoxia. Additionally, it replicates peroxidase (GPX) utilizing iron (Fe3+) reduce overexpression GSH. These two mechanisms act concert amplify They achieve enhancing production impairing GSH scavenge ROS, thereby synergistically potentiating vitro vivo studies have evidence efficient generation, resulting significant 6-fold reduction volume compared control groups achieving an impressive 80% survival rate 30 days after treatment.

Language: Английский

Citations

3