Supramolecular Switching-Enabled Quorum Sensing Trap for Pathogen-Specific Recognition and Eradication to Treat Enteritis DOI
Xiaojie Wu,

Qinggele Borjihan,

Yueying Su

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Intestinal bacterial infections have become a significant threat to human health. However, the current typical antibiotic-based therapies not only contribute drug resistance but also disrupt gut microbiota balance, resulting in additional adverse effects on life activities. There is an urgent need develop new antibacterial materials that selectively eliminate pathogenic bacteria without disrupting beneficial communities or promoting resistance. Herein, we utilize quorum sensing (QS), universal mechanism for regulating community behavior, supramolecular QS trap by encapsulating cucurbit[7]uril (CB[7]) 1-vinyl-3-pentylimidazolium bromide ([VPIM]Br) form switch ([VPIM]Br⊂CB[7]) through host–guest interactions followed grafting it onto cell surfaces using atom transfer radical polymerization. Subsequently, matched pathogens are recognized and aggregated interbacterial signals. Furthermore, addition of amantadine (AD) facilitates release [VPIM]Br competitive binding CB[7] [VPIM]Br⊂CB[7] sterilization. This specifically triggers self-aggregation efficient elimination bacteria. The [VPIM]Br⊂CB[7]-based can increase diversity abundance intestinal microorganisms mice, effectively treating Escherichia coli K88-induced damage perturbing balance. supramolecular-switched opens up promising avenue recognize eradicate antibiotic-free treatment other inflammatory diseases.

Language: Английский

Mechanics‐Resilient HA/SIS‐Based Composite Scaffolds with ROS‐Scavenging and Bacteria‐Resistant Capacity to Address Infected Bone Regeneration DOI
Zelong Song,

Haichao Yu,

Linhao Hou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Jan. 23, 2024

Abstract To address and regenerate infected bone defects complicated by issues such as inflammation resorption, to promote regeneration, this study focuses on the development of a composite scaffold with reactive oxygen species (ROS)‐scavenging bacteria‐resistant properties. The integrates self‐assembled small intestinal submucosa (SIS) hydrogel pre‐adsorbed hydroxyapatite (HA) particles tannic acid (TA), demonstrating distinctive mechanical resilience porous structures, suitable for filling irregular cavities facilitating cell infiltration, while exhibiting broad‐spectrum antibacterial efficacy robust ROS‐scavenging capacity tissue regeneration. RNA‐sequencing analysis indicates underlying mechanism revealing disrupting arginine alanine amino biosynthesis. Furthermore, demonstrates excellent cytocompatibility, viability exceeding 70%. Remarkably, it exceptional anti‐inflammatory performances (≈5‐fold control). In an defect model, facilitates superior being ≈5‐fold greater than control, maintaining conducive environment adhesion infiltration without collapse. This multifunctional emerges promising candidate combating infections in showcasing its potential addressing complex bone‐related challenges.

Language: Английский

Citations

18
The application of small intestinal submucosa in tissue regeneration DOI Creative Commons
Yifan Zhao,

Hongyi Peng,

Lingxiang Sun

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101032 - 101032

Published: March 18, 2024

The distinctive three-dimensional architecture, biological functionality, minimal immunogenicity, and inherent biodegradability of small intestinal submucosa extracellular matrix materials have attracted considerable interest found wide-ranging applications in the domain tissue regeneration engineering. This article presents a comprehensive examination structure role submucosa, delving into diverse preparation techniques classifications. Additionally, it proposes approaches for evaluating modifying SIS scaffolds. Moreover, advancements skin, bone, heart valves, blood vessels, bladder, uterus, urethra are thoroughly explored, accompanied by their respective future prospects. Consequently, this review enhances our understanding organ repair keeps researchers up-to-date with latest research area.

Language: Английский

Citations

11
Versatile Bioactive Glass/Zeolitic Imidazolate Framework-8-Based Skin Scaffolds toward High-Performance Wound Healing DOI

Yongchun Hou,

Xiaowei Xu,

Yaqin Zhou

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8228 - 8237

Published: Feb. 12, 2024

Designing a novel biomaterial for wound healing is based on biocompatibility and excellent mechanical strength. In this study, bioactive glass (BG) zeolitic imidazolate framework-8 (ZIF-8) have been incorporated into poly(ε-caprolactone)/poly(vinyl alcohol) (PCL/PVA) composite skin scaffolds via microfluidic electrospinning. Interestingly, the addition of ZIF-8 further strengthens BG stability demonstrates better antibacterial effects. Utilizing slow release Zn, Ca, Si ions, it also significantly promotes growth factor expression regeneration. addition, demonstrated by in vitro vivo studies that prepared possess biocompatibility, capabilities, properties. The BG/ZIF-8-loaded scaffold possesses high tensile strength (26 MPa) properties (achieves 89.64 78.8% inhibition E. coli S. aureus, respectively), cell viability increased 51.2%. More importantly, shrinkage than an unloaded scaffold, rates PCL/PVA@BG/ZIF-8(1 wt %) group 95% with 2.2 mm granulation thickness within 12 days. Thus, loaded BG/ZIF-8 electrospinning provides new perspective accelerating potential therapeutic strategy efficient healing.

Language: Английский

Citations

6
Multifunctional hydrogel based on polyvinyl alcohol/chitosan/metal polyphenols for facilitating acute and infected wound healing DOI Creative Commons

Ruigang Zhou,

Junjie Huang, Wen‐Hai Zhang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101315 - 101315

Published: Oct. 31, 2024

Language: Английский

Citations

5
Cu-MOF loaded chitosan based freeze-dried highly porous dressings with anti-biofilm and pro-angiogenic activities accelerated Pseudomonas aeruginosa infected wounds healing in rats DOI

Saima Zulfiqar,

Shahzad Sharif, Muhammad Nawaz

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132443 - 132443

Published: May 16, 2024

Language: Английский

Citations

4
Spatiotemporal delivery of microenvironment responsive hydrogel incorporated with stem cells-loaded porous microspheres for abdominal wall repair DOI

Liuxin Yang,

Dandan Wei, Yinghua Tao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154435 - 154435

Published: Aug. 6, 2024

Language: Английский

Citations

4
Engineered scallion-derived exosomes boosting small intestinal submucosa patches for gastrointestinal anastomosis and regeneration DOI

Xudong Peng,

Chaozheng Xie, Pengfei Wei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161853 - 161853

Published: March 1, 2025

Language: Английский

Citations

0
A Pro-Healing and Antibacterial Bio-Based Hydrogel Barrier for the Prevention of Intestinal Anastomotic Leakage DOI

Yiheng Ju,

Dongjie Zhang,

Huijie Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Postoperative leakage at the colorectal anastomosis is recognized as a significant and serious complication. Its pathogenic factors are complex, onset process hidden, it often complicated with severe abdominal infection, which leads to sepsis even multiple organ failure. In order develop new type of multifunctional biomaterial can prevent intestinal bacterial translocation, fluid spillage promote healing anastomosis, we prepared temperature-sensitive extracellular matrix hydrogel (ECM) porcine small submucosa (SIS) physically modified by boric acid 4-ARM-PEG-SC raw materials, in avoid infection anastomotic leakage. A series experiments showed that had stable structure, could resist erosion digestive juice physiological range good tissue adhesion mechanical properties, excellent antiexplosion ability self-healing. Combined its injectability, effectively seal anastomosis. vitro effective antidigestion ability, antibacterial cell blood compatibility, well antioxidant anti-inflammatory capabilities. Experiments revealed optimize local microenvironment repair reduce incidence colonic rats promoting key proliferation, facilitating vascular formation curtailing expression pro-inflammatory factors. The findings this study pave way for novel strategies creating materials designed manage

Language: Английский

Citations

0
Dynamic multistage nanozyme hydrogel reprograms diabetic wound microenvironment: synergistic oxidative stress alleviation and mitochondrial restoration DOI Creative Commons
Jingyu Yan, Yifan Zhao,

Chenying Cui

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101780 - 101780

Published: April 17, 2025

Chronic diabetic wounds remain a significant clinical challenge due to persistent bacterial infections, oxidative stress, impaired angiogenesis, and mitochondrial dysfunction. Traditional therapies often fail address these interrelated pathological factors, highlighting the urgent need for innovative solutions. Here, we present Mn-ZIF@GOx/BC (MZGB) hydrogel system, where Mn-ZIF@GOx (MZG) nanozymes are successfully integrated into cellulose (BC) via hydrogen bonding electrostatic interactions. The MZGB lowers wound pH by oxidizing excess glucose gluconic acid. It exhibits strong ROS scavenging capabilities through its superoxide dismutase catalase-like activities, while simultaneously providing oxygen. By restoring redox homeostasis, it protects function enhances cellular energy metabolism. reprogramming macrophages, creates favorable immune microenvironment, significantly promoting angiogenesis paracrine mechanisms. This facilitates cell-to-cell communication, forming positive feedback loop. Moreover, demonstrates ROS-independent antibacterial properties. BC ensures adhesion moisture regulation, protective barrier maintaining an optimal environment. multifunctional represents promising nanotherapeutic approach efficiently treating precisely regulating microenvironment.

Language: Английский

Citations

0
A Piezoelectric and Suture‐Free Cardiac Patch Assembled by all FDA‐approved Materials Achieves a Minimally Invasive Gene Therapy DOI
Tingting Ye, Yaping Li, Xiaolin Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Balancing biosafety with multifunctionality remains a critical challenge in biopatch development, impeding clinical translation. This study introduces minimally invasive myocardial patch fabricated entirely from FDA‐approved components, integrating piezoelectric property and sustained release of miRNA agomir. Briefly, the small intestinal submucosa (SIS) serves as matrix for situ growth β‐cyclodextrin metal‐organic framework (β‐CD‐MOF). Cholesterol‐modified miR‐210 Agomir is efficiently loaded into cyclodextrin cavities through host‐guest interactions. Flexibility water‐triggered adhesion properties, bestowed by poly (sodium thioctate) (PST) coating on rim, allow dry SIS‐Patch to fold catheter‐deliverable tube implantation. In rat infarction models, Ago‐Patch achieved release, effectively downregulating target gene expression. Simultaneously, SIS converts mechanical energy vivo electrical pulses, activating related signaling pathway. Synergistic gene‐electrical therapy improved cardiac function, increasing ejection fraction 14.0% fractional shortening 10.4%, while attenuating left ventricular remodeling fibrosis. The Ago‐Patch's dual‐action mechanism offers safe, multifunctional solution repair.

Language: Английский

Citations

0