Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Intestinal
bacterial
infections
have
become
a
significant
threat
to
human
health.
However,
the
current
typical
antibiotic-based
therapies
not
only
contribute
drug
resistance
but
also
disrupt
gut
microbiota
balance,
resulting
in
additional
adverse
effects
on
life
activities.
There
is
an
urgent
need
develop
new
antibacterial
materials
that
selectively
eliminate
pathogenic
bacteria
without
disrupting
beneficial
communities
or
promoting
resistance.
Herein,
we
utilize
quorum
sensing
(QS),
universal
mechanism
for
regulating
community
behavior,
supramolecular
QS
trap
by
encapsulating
cucurbit[7]uril
(CB[7])
1-vinyl-3-pentylimidazolium
bromide
([VPIM]Br)
form
switch
([VPIM]Br⊂CB[7])
through
host–guest
interactions
followed
grafting
it
onto
cell
surfaces
using
atom
transfer
radical
polymerization.
Subsequently,
matched
pathogens
are
recognized
and
aggregated
interbacterial
signals.
Furthermore,
addition
of
amantadine
(AD)
facilitates
release
[VPIM]Br
competitive
binding
CB[7]
[VPIM]Br⊂CB[7]
sterilization.
This
specifically
triggers
self-aggregation
efficient
elimination
bacteria.
The
[VPIM]Br⊂CB[7]-based
can
increase
diversity
abundance
intestinal
microorganisms
mice,
effectively
treating
Escherichia
coli
K88-induced
damage
perturbing
balance.
supramolecular-switched
opens
up
promising
avenue
recognize
eradicate
antibiotic-free
treatment
other
inflammatory
diseases.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 24, 2024
Hydrogel
is
considered
as
a
promising
candidate
for
wound
dressing
due
to
its
tissue-like
flexibility,
good
mechanical
properties
and
biocompatibility.
However,
traditional
hydrogel
dressings
often
fail
fulfill
satisfied
mechanical,
antibacterial,
biocompatibility
simultaneously,
the
insufficient
intrinsic
bactericidal
efficacy
addition
of
external
antimicrobial
agents.
In
this
paper,
hydroxyl-contained
acrylamide
monomers,
N-Methylolacrylamide
(NMA)
N-[Tris
(hydroxymethyl)methyl]
(THMA),
are
employed
prepare
series
polyacrylamide
xNMA-yTHMA,
where
x
y
represent
mass
fractions
NMA
THMA
in
hydrogels.
We
have
elucidated
that
abundance
hydroxyl
groups
determines
antibacterial
effect
Particularly,
35NMA-5THMA
exhibits
excellent
properties,
with
high
tensile
strength
259
kPa
large
strain
1737%.
Furthermore,
demonstrates
remarkable
inherent
without
exogenous
agents
owing
existence
abundant
groups.
Besides,
possesses
biocompatibility,
view
marginal
cytotoxicity,
low
hemolysis
ratio,
negligible
inflammatory
response
organ
toxicity
mice
during
treatment.
Encouragingly,
drastically
promote
healing
bacteria-infected
mice.
This
study
has
revealed
importance
polyhydroxyl
efficiency
hydrogels
provided
simplified
strategy
design
translational
potential.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 16, 2024
In
patients
with
abdominal
or
pelvic
tumors,
radiotherapy
can
result
in
radiation-induced
intestinal
injury
(RIII),
a
potentially
severe
complication
for
which
there
are
few
effective
therapeutic
options.
Sitagliptin
(SI)
is
an
oral
hypoglycemic
drug
that
exhibits
antiapoptotic,
antioxidant,
and
anti-inflammatory
activity,
but
how
it
influences
RIII-associated
outcomes
has
yet
to
be
established.
this
study,
pH-responsive
metal-organic
framework-based
nanoparticle
platform
was
developed
the
delivery
of
SI
(SI@ZIF-8@MS
NP).
These
NPs
incorporated
mPEG-b-PLLA
(MS)
as
agent
capable
resisting
effects
gastric
acid,
releasing
Zn
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Intestinal
bacterial
infections
have
become
a
significant
threat
to
human
health.
However,
the
current
typical
antibiotic-based
therapies
not
only
contribute
drug
resistance
but
also
disrupt
gut
microbiota
balance,
resulting
in
additional
adverse
effects
on
life
activities.
There
is
an
urgent
need
develop
new
antibacterial
materials
that
selectively
eliminate
pathogenic
bacteria
without
disrupting
beneficial
communities
or
promoting
resistance.
Herein,
we
utilize
quorum
sensing
(QS),
universal
mechanism
for
regulating
community
behavior,
supramolecular
QS
trap
by
encapsulating
cucurbit[7]uril
(CB[7])
1-vinyl-3-pentylimidazolium
bromide
([VPIM]Br)
form
switch
([VPIM]Br⊂CB[7])
through
host–guest
interactions
followed
grafting
it
onto
cell
surfaces
using
atom
transfer
radical
polymerization.
Subsequently,
matched
pathogens
are
recognized
and
aggregated
interbacterial
signals.
Furthermore,
addition
of
amantadine
(AD)
facilitates
release
[VPIM]Br
competitive
binding
CB[7]
[VPIM]Br⊂CB[7]
sterilization.
This
specifically
triggers
self-aggregation
efficient
elimination
bacteria.
The
[VPIM]Br⊂CB[7]-based
can
increase
diversity
abundance
intestinal
microorganisms
mice,
effectively
treating
Escherichia
coli
K88-induced
damage
perturbing
balance.
supramolecular-switched
opens
up
promising
avenue
recognize
eradicate
antibiotic-free
treatment
other
inflammatory
diseases.
