Pair Potential between Poloxamer 407 Micelles in 14 wt % Aqueous Solution Clarifying the Sol–Gel–Sol Transition by Temperature Rise DOI
Takeshi Morita,

Yusuke Torii,

Hiroshi Imamura

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(31), P. 7909 - 7915

Published: July 27, 2024

Poloxamer 407 (P407) is used as a safety-guaranteed, invaluable pharmaceutical nanocarrier. The aqueous solution of P407 exhibits sol-to-gel and gel-to-sol transitions, specifically during temperature rise. Here, we develop method to determine the pair potential between colloidal particles based primarily on experimental small-angle scattering data. Using this approach, micelles in sol–gel–sol transition state revealed without prelimiting any type interaction forces. results indicate that increase attractive contributes enhancing volume fraction, which decisive parameter for gelation terms Alder theory, i.e., fluid-to-crystal phase hard-sphere model micelle system. This study demonstrates one key mechanisms upon heating enhancement structural fluctuation due widening well intermicellar potential.

Language: Английский

Synergistic dual Ag/Cu ion implantation to enhance antimicrobial defense on Boston Keratoprosthesis DOI Creative Commons
Silvia González Gómez, Gerard Boix‐Lemonche, Jordi Orrit‐Prat

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

The Boston keratoprosthesis (BKPro) is a critical device for vision restoration in complex cases of corneal blindness, although its long-term retention challenged by infection risks. This study aims to enhance the antimicrobial properties titanium (Ti) backplate BKPro ion implanting silver and copper ions achieve effective control while maintaining cytocompatibility. Research on modifications limited, metallic like Ag Cu show promise biomaterial improvement, their effects human keratocytes (HCKs) require further study. were implanted onto rough Ti surfaces, as mono- coimplantations. Cytotoxicity was assessed HCKs, efficacy tested against Pseudomonas aeruginosa Candida albicans . After 21 d, monoimplanted samples released 300.4 ppb + , coimplanted 427.5 272.3 ions, 567.0 ions. All ion-implanted surfaces supported HCK proliferation, exhibited no cytotoxicity, showed strong activity. Ag-implanted provided antibacterial through membrane disruption reactive oxygen species generation, Cu-implanted antifungal via impaired enzymatic functions species. Coimplanted AgCu demonstrated synergistic effects, resulting from synergy between bactericidal actions oxidative stress contributions Cu. Additionally, enhanced adhesion under co-culture conditions. In conclusion, implantation effectively imparts BKPro, reducing risks preserving compatibility with cells.

Language: Английский

Citations

0
Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments? DOI Creative Commons
Meekha George, Rabah Boukherroub,

Amitav Sanyal

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101616 - 101616

Published: Feb. 26, 2025

Language: Английский

Citations

0
Suture‐Free Corneal Transplantation via Bioself‐Adhesive Lenticules Based on Macromolecular Electrostatic Entanglement DOI Open Access

Zhe Zhang,

Yanze Yu,

Ding Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The corneal lenticules extracted from small incision lenticule extraction (SMILE) can be used as an optional transplantation material. However, it cannot for deep anterior lamellar keratoplasty due to its thickness limitations. In this study, oxidized chondroitin sulfate (O─CS) containing ─SO 3 − groups twisted with generation 4.0 polyamidoamine dendrimers (G4 PAMAM) which contain −NH 2 + via electrostatic entanglement form a cohesive module, is applicable in suture‐free of cornea, providing the possibility repairing defects. intermolecular enhanced self‐adhesion module (33.80 ± 2.12 kPa) high light transmittance (more than 70%) and excellent biocompatibility, benefits stable adhesion long term. Additionally, G4 PAMAM control long‐term puerarin drug release then inhibit postoperative inflammatory response. bioself‐adhesion between macromolecules realize tissues, provides promising strategy living tissue wound repair.

Language: Английский

Citations

0
Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery DOI
Milad Abbasi, Hossein Aghamollaei, Ahmad Vaez

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Antibacterial and cytocompatible silver coating for titanium Boston Keratoprosthesis DOI Creative Commons
Silvia González Gómez, Maria‐Pau Ginebra, F.J. Gil

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 19, 2024

The Boston Keratoprosthesis (BKPro) serves as a medical solution for restoring vision in complex cases of corneal blindness. Comprising front plate made polymethylmethacrylate (PMMA) and back titanium (Ti), this device utilizes the beneficial biomaterial properties Ti. While BKPro demonstrates promising retention rates, infection emerges significant concern that impacts its long-term efficacy. However, limited research exists on enhancement BKPros through intrinsic infection-preventing mechanisms. In regard, metal ions, especially well-known Ag + are alternative to obtain implants with innate antibacterial properties. little information is available about effects tissue, within human keratocytes (HCKs). work, an electrodeposition treatment using constant pulse proposed attach complexes onto rough Ti surfaces, thus providing without inducing cytotoxicity. Complete physicochemical characterization ion release studies were carried out both control Ag-treated samples. possible cytotoxic short long term evaluated vitro HCKs. Moreover, silver-treated surfaces tested against gram-negative bacterial strain Pseudomonas aeruginosa gram-positive Staphylococcus epidermidis , common contributors infections BKPros. Physicochemical confirmed presence silver, predominantly oxide form, low ions. demonstrated no cytotoxicity promoted proliferation Furthermore, exhibited potent effect, causing reduction adhesion evident damage cell walls P. S. . ions suggested reactive oxygen species (ROS)-mediated oxidative stress imbalance bactericidal mechanism silver deposits. conclusion, technique confers protection backplate BKPro, mitigating implant-threatening while ensuring non-cytotoxicity tissue.

Language: Английский

Citations

1
Revamping the corneal permeability and antiglaucoma therapeutic potential of brinzolamide using transniosomes: optimization, in vitro and preclinical evaluation DOI

Rushikesh K Patil,

Vaibhavi Srivastava, Rohit Bhawale

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(11), P. 947 - 964

Published: March 14, 2024

Aim: This study aims to explore potential of transniosomes, a hybrid vesicular system, as ocular drug-delivery vehicle. Materials & methods: Thin-film hydration technique was used fabricate brinzolamide-loaded transniosomes (BRZ-TN) and optimized using Box–Behnken design, further exhaustively characterized for physicochemical evaluations, deformability, drug release, permeation preclinical evaluations antiglaucoma activity. Results: The BRZ-TN showed ultradeformability (deformability index: 5.71), exhibiting sustained release without irritation (irritancy score: 0) high permeability compared with the marketed formulation or free suspension. extensive in vivo investigations affirmed effective targeted delivery brinzolamide reducing intraocular pressure potentially. Conclusion: Our findings anticipated that is promising therapeutic nanocarrier effectively delivering cargo sites by crossing corneal barriers.

Language: Английский

Citations

0
Pair Potential between Poloxamer 407 Micelles in 14 wt % Aqueous Solution Clarifying the Sol–Gel–Sol Transition by Temperature Rise DOI
Takeshi Morita,

Yusuke Torii,

Hiroshi Imamura

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(31), P. 7909 - 7915

Published: July 27, 2024

Poloxamer 407 (P407) is used as a safety-guaranteed, invaluable pharmaceutical nanocarrier. The aqueous solution of P407 exhibits sol-to-gel and gel-to-sol transitions, specifically during temperature rise. Here, we develop method to determine the pair potential between colloidal particles based primarily on experimental small-angle scattering data. Using this approach, micelles in sol–gel–sol transition state revealed without prelimiting any type interaction forces. results indicate that increase attractive contributes enhancing volume fraction, which decisive parameter for gelation terms Alder theory, i.e., fluid-to-crystal phase hard-sphere model micelle system. This study demonstrates one key mechanisms upon heating enhancement structural fluctuation due widening well intermicellar potential.

Language: Английский

Citations

0