Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review DOI

J. Yao,

Zhencun Cui,

Feifei Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 136

Published: Nov. 6, 2024

This article reviews the application of biomaterials in combination with immunotherapy to enhance localized treatment tumors, along current challenges and future development directions this field.

Language: Английский

Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy DOI

Guanghui Hou,

Youdong Chen,

Huali Lei

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.

Language: Английский

Citations

1
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy DOI Creative Commons
Ying‐Li Luo,

Maoyuan Linghu,

Xianyu Luo

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Stain Alkynes. DOI Creative Commons

Lydia Cooke,

Katie Gristwood,

Kate Adamson

et al.

Published: May 17, 2024

Phenanthroline-type ligand containing annealed 1,2,4-triazine ring was used to prepare novel Ir(III) complexes 3 and 4. The are non-luminescent but show luminogenic behaviour following inverse electron demand Diels-Alder (IEDDA) reaction with bicyclononyne (BCN) derivatives. It observed that the complex reacts BCN-C10 three times faster than corresponding free 7. magnitude of this accelerating metal-coordination effect, however, is less profound in previously reported 1,2,4-triazines which triazine directly coordinated metal centre. Nevertheless, opens prospects for use such bioimaging applications, demonstrated by developing a convenient methodology using “chemistry on complex” concept labelling antibodies luminescent complexes. Bioorthogonal reactivity 4 then evaluated metabolically live cells BCN groups followed IEDDA iridium complex.

Language: Английский

Citations

0
Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Stain Alkynes DOI Creative Commons

Lydia Cooke,

Katie Gristwood,

Kate Adamson

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(37), P. 15501 - 15508

Published: Jan. 1, 2024

A phenanthroline-type ligand containing an annealed 1,2,4-triazine ring was used to prepare novel Ir(III) complexes 3 and 4. The are non-luminescent but show luminogenic behaviour following the inverse electron demand Diels-Alder (IEDDA) reaction with bicyclononyne (BCN) derivatives. It observed that react BCN-C10 faster than corresponding free ligands. magnitude of this accelerating metal-coordination effect, however, is less profound in previously reported 1,2,4-triazines, which triazine directly coordinated metal centre. Nevertheless, opens prospects for use such bioimaging applications, demonstrated by developing a convenient methodology using "chemistry on complex" concept labelling antibodies luminescent complexes. bioorthogonal reactivity complex 4 metabolically live cells BCN groups, followed IEDDA iridium complex.

Language: Английский

Citations

0
Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review DOI

J. Yao,

Zhencun Cui,

Feifei Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 136

Published: Nov. 6, 2024

This article reviews the application of biomaterials in combination with immunotherapy to enhance localized treatment tumors, along current challenges and future development directions this field.

Language: Английский

Citations

0