Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer DOI Creative Commons
Hongyu Liu,

T.-C. Wu,

Yunjian Yu

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

ABSTRACT Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs complex procedures, which are inconvenient large‐scale screening. Given its high prevalence in malignant tissues feces of patients, Fusobacterium nucleatum ( F. ) has emerged as a crucial biomarker CRC. Herein, we propose ‐specific recognition diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between FadA on allows AIE‐Pep NPs to adhere selectively , emits strong red/NIR fluorescence. In model orthotopic CRC, can precisely localize around Moreover, demonstrated limit (LOD) 82.97 CFU/mL could significantly differentiate mice from those normal mice. Overall, this study presents pivotal approach specifically identifying holds immense potential

Language: Английский

Citations

1
Tumor and intratumoral pathogen cascade-targeting photothermal nanotherapeutics for boosted immunotherapy of colorectal cancer DOI

Youtao Xin,

Yunjian Yu,

Mengdi Wu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 574 - 591

Published: Jan. 24, 2025

Language: Английский

Citations

0
Cyclodextrin-based nanotherapeutics: A promising strategy for enhanced cancer therapy DOI
Menglin Zhang,

Fanpeng Ran,

Yun Zhang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111232 - 111232

Published: April 1, 2025

Language: Английский

Citations

0
Light-responsive glycosidase inhibitors: Tuning enzyme selectivity and switching factors through integrated chemical and optoglycomic strategies DOI Creative Commons
Gonzalo Rivero-Barbarroja, Stéphane Maisonneuve, Juan Xie

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108575 - 108575

Published: May 1, 2025

Language: Английский

Citations

0
Advanced hydrogel material for colorectal cancer treatment DOI Creative Commons
Yu Guo,

Min Wang,

Yu‐Zhong Zhang

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 32(1)

Published: Dec. 31, 2024

Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year. Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, immunotherapy. Although various agents have been used in treatment malignant tumors, they not as effective expected. This primarily owing to lack selectivity, poor solubility, severe side effects agents. It necessary develop more efficient drug delivery systems precise targeting tumor site therapeutic meet clinical needs. A hydrogel a three-dimensional network material composed crosslinked chains hydrophilic or hydrophobic groups polymer backbone. Hydrogels possess useful properties including high water content, adjustable physical characteristics, elasticity, flexibility, reversible swelling, multifunctionality. These render them ideal biomaterials with broad range applications biomedicine bioengineering. In this review, we introduce pathophysiology current advances summarize hydrogels different materials well smart response carriers treatment. We also analyze unique advantages challenges using therapy.

Language: Английский

Citations

2
Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

Citations

0