Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(5), P. 167169 - 167169
Published: April 15, 2024
Language: Английский
The Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 222(3)
Published: Feb. 16, 2023
Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles including mitochondria shown move between mammalian culture via cytoplasmic bridges. Recent research animals indicates transfer of cancer and during lung injury vivo, with considerable functional consequences. Since these pioneering discoveries, many studies have confirmed horizontal mitochondrial (HMT) its characteristics consequences been described. Additional support for this phenomenon has come from phylogenetic studies. Apparently, trafficking occurs more frequently than previously contributes diverse processes bioenergetic crosstalk homeostasis, disease treatment recovery, development resistance therapy. Here we highlight current knowledge HMT cells, focusing primarily on vivo systems, contend that process is not only (patho)physiologically relevant, but also can exploited the design novel therapeutic approaches.
Language: Английский
Citations
50
Progress in Retinal and Eye Research, Journal Year: 2023, Volume and Issue: 93, P. 101169 - 101169
Published: Feb. 1, 2023
Language: Английский
Citations
48
eLife, Journal Year: 2023, Volume and Issue: 12
Published: March 2, 2023
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from one cell to another, can affect cellular and tissue homeostasis. Most what we know about transfer stems bulk have led paradigm functional transferred restore bioenergetics revitalize functions recipient cells with damaged or non-functional networks. However, show also occurs between functioning endogenous networks, but mechanisms underlying how promote such sustained behavioral reprogramming remain unclear. We report unexpectedly, macrophage are dysfunctional accumulate reactive oxygen species in cancer cells. further discovered accumulation activates ERK signaling, promoting proliferation. Pro-tumorigenic macrophages exhibit fragmented leading higher rates Finally, observe promotes tumor proliferation vivo. Collectively these results indicate activate downstream signaling pathways a ROS-dependent manner cells, provide model be mediated by relatively small amount vitro
Language: Английский
Citations
41
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Language: Английский
Citations
29
Nature Reviews Drug Discovery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
6
Progress in Retinal and Eye Research, Journal Year: 2023, Volume and Issue: 96, P. 101205 - 101205
Published: July 15, 2023
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ that has one of highest metabolic rates body-wide constantly exposed photooxidative damage external stressors. Mitophagy selective autophagic degradation mitochondria within lysosomes, can be triggered by distinct stimuli such as mitochondrial or hypoxia. Here, we review importance mitophagy retinal physiology pathology. In developing essential for reprogramming differentiation retina ganglion cells (RGCs). basal conditions, acts a quality control mechanism, maintaining healthy pool meet cellular demands. We summarize different autophagy- mitophagy-deficient mouse models described literature, discuss potential role dysregulation diseases glaucoma, diabetic retinopathy, retinitis pigmentosa, age-related macular degeneration. Finally, provide overview methods used monitor vitro, ex vivo, vivo. This highlights important sustaining visual function, its putative therapeutic target other diseases.
Language: Английский
Citations
31
Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112115 - 112115
Published: Feb. 1, 2023
Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy broadly used to improve cellular health and viability. Here, we investigate mitochondrial homeostasis in the vertebrate cone photoreceptor, specialized neuron initiates our daytime color vision. We find generalizable response stress leads loss cristae, displacement from their normal location, initiation degradation, Müller glia cells, key non-neuronal support cell retina. Our findings show transmitophagy cones as damage. represents an outsourcing mechanism photoreceptors use function.
Language: Английский
Citations
23
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102038 - 102038
Published: Aug. 23, 2023
Language: Английский
Citations
22
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7151 - 7167
Published: Feb. 17, 2024
Language: Английский
Citations
8
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(15), P. 2729 - 2740
Published: July 2, 2024
Polychlorinated biphenyls (PCBs) are industrial chemicals that ubiquitously found in the environment. Exposure to these compounds has been associated with neurotoxic outcomes; however, underlying mechanisms for such outcomes remain be fully understood. Recent studies have shown astrocytes, most abundant glial cell type brain, susceptible PCB exposure as well human-relevant metabolites of PCBs. Astrocytes critical maintaining healthy brain function due their unique functional attributes and positioning within neuronal networks brain. In this study, we assessed toxicity PCB52, one abundantly congeners outdoor indoor air, two its metabolites, on astrocyte mitochondria. We exposed C6 cells, an line, PCB52 or all showed increased galactose-containing media compared glucose-containing media, indicating involvement mitochondria observed toxicity. Additionally, also oxidative stress upon metabolites. All three caused a loss mitochondrial membrane potential, distinct changes structure, impaired function. The hydroxylated metabolite 4-OH-PCB52 likely functions uncoupler This is first study report adverse effects structure astrocytes.
Language: Английский
Citations
8