Negatively Charged Peptides Assisted Gold Nanorod‐Based Nano‐Magic Bullet for Mitochondria‐Targeting and Imaging‐Guided Synergistic Photothermal/Dynamic Therapy DOI
Chenglong Zhao,

Linjie Ju,

Lihua Huang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Abstract Mitochondria‐targeting synergistic photothermal/dynamic therapy (PTT/PDT) represents a promising approach for enhancing cancer therapy. However, only few such smart nanoparticles are currently available and most of them with existing moieties targeting mitochondria based on the delocalized lipophilic cations, which pose potential toxicity due to their accumulation in mitochondrial membrane. Herein, multifunctional “nano‐magic bullet” (AuNR‐Ce6) is designed engineered negatively charged peptides mitochondria‐targeting, imaging‐guided PTT/PDT. AuNR‐Ce6 prepared gold nanorods (AuNRs, as PTT) bullet cores peptide linked Ce6 (as PDT). It proved that nanorod‐like structure formed by can efficiently deliver AuNRs into be specifically cleaved enterokinase (ENTK, overexpressed cells), subsequently resulting fluorescence ON reactive oxygen species (ROS) burst. Furthermore, from generate enhanced ROS cells, thereby leading selective killing cells regression tumor growth. Thus, this nanoplatform not used mitochondria‐targeting guided imaging via detecting intracellular ENTK levels, but also inhibit growth vitro vivo through

Language: Английский

Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy DOI

Mengyan Tian,

Yucong Li,

Yaning Li

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Abstract Benefit from the deeper penetration of mechanical wave, ultrasound (US)‐based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep‐seated tumors. Nevertheless, complicated mechanism SDT undeniably hinders exploration ingenious sonosensitizers. Herein, a receptor engineering strategy aggregation‐induced emission (AIE) sonosensitizers (TPA‐Tpy) with acceptor (A)‐donor (D)‐A’ structure is proposed, which inspects effect increased cationizations on US sensitivity. Under stimulation, enhanced cationization TPA‐Tpy improves intramolecular charge transfer (ICT) and accelerates separation, possesses non‐negligible promotion type I reactive oxygen species (ROS) production. Moreover, abundant ROS‐mediated mitochondrial oxidative stress triggers satisfactory immunogenic cell death (ICD), further promotes combination ICD. Subsequently, subacid pH‐activated nanoparticles (TPA‐Tpy NPs) are constructed charge‐converting layer (2,3‐dimethylmaleic anhydride‐poly (allylamine hydrochloride)‐polyethylene glycol (DMMA‐PAH‐PEG)) TPA‐Tpy, achieving controllable release In vivo, TPA‐Tpy‐mediated effectively initiates surface‐exposed calreticulin (ecto‐CRT), dendritic cells (DCs) maturation, CD8 + T infiltration rate through ROS production, suppression ablation primary metastatic This study provides new opinions regulating acceptors eminent sensitization, brings novel ICD sono‐inducer based to realize superior antitumor effect.

Language: Английский

Citations

11
Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice DOI Creative Commons
Yizong Liu, Shuya Wang, Jiaxiong Zhang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 6, 2024

Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack effective treatments. Interactions between cardiomyocytes and MI microenvironment (MIM) can determine progression fate infarcted myocardial tissue. Here, specially designed Melanin-based composite nanomedicines (MCN) is developed effectively treat by reprogramming MIM. MCN nanocomposite composed polydopamine (P), Prussian blue (PB) cerium oxide (CexOy) with Mayuan-like structure, which MIM efficient conversion detrimental substances (H+, reactive oxygen species, hypoxia) into beneficial status (O2 H2O). In coronary artery ligation ischemia reperfusion models male mice, intravenously injecting specifically targets damaged area, resulting in restoration cardiac function. With its promising therapeutic effects, constitutes new agent for treatment demonstrates potential clinical application. most common emergent manifestation cardiovascular diseases. authors nanomedicine that reprogram converting ROS elements H2O), as such

Language: Английский

Citations

11
Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis DOI Creative Commons
Jianmei Gao, Y.L. He, Feng Shi

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is naturally-occurring neuroprotectant with Sirt6 induction potency. However, it unknown whether ICS protects against PSD through modulation of microbiota. This study aimed to reveal the effect and potential mechanisms on PSD, microbiota-gut-brain axis was investigated. Using middle cerebral artery occlusion (MCAO) chronic unpredictable mild stress (CUMS) establish post-stroke (PSD) mice, we assessed anti-depressant effects via behavioral tests, immunohistochemistry, western blot. Transcriptome profiling, molecular docking, surface plasmon resonance were used identify key targets. 16S rDNA genomic-derived taxonomic profiling fecal transplantation (FMT) conducted figure out mechanistic short-chain fatty acids (SCFAs). ameliorated depressive-like behaviors mice as evidenced by sucrose preference test, forced swimming test tail suspension test. restored mitochondrial function, reduced oxidative damage pro-inflammatory cytokines both brain intestine regulation Sirt6/NF-κB pathway. significantly increased abundance (such asAkkermansia Ligilactobacillus), enhanced SCFAs concentrations, repaired intestinal barrier integrity upreglated tight junction protein expression. FMT from II-treated replicated these benefits, confirming microbiota's role. Mechanistically, directly bound its activity. Ⅱ-mediated neuroprotection neutralized or hydrogen peroxide-induced enteric glial cells when absent. Our findings expand pharmacological properties II demonstrating ability ameliorate axis. Ⅱ, novel activator, could be translated into an alternative microbiota-targeted avenue for coping PSD.

Language: Английский

Citations

2
Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke DOI Open Access
Rui Wang,

Weimin Nie,

Xin Yan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Nerve injury represents the primary reason of mortality and disability in ischemic stroke, but effective drug delivery to region cerebral ischemia hypoxia poses a significant challenge neuroprotective treatment. To address these clinical challenges, biomimetic nanomotor, Pt@LF is designed, facilitate deep agents inhibit ferroptosis stroke. traverses blood-brain barrier (BBB) penetrates into ischemic-hypoxic areas due active targeting capacity apo-lactoferrin (Apo-LF) self-propelling motion properties nanomotors. Subsequently, loosens thrombus alleviates "no reflow" phenomenon via mechanical thrombolysis. Thanks various enzyme-like abilities multi-target inhibition capability, ameliorates inflammatory microenvironment rescues dying neurons. In conclusion, demonstrates efficiently penetration effects vitro vivo. And this study provides promising therapeutic platform for treatment

Language: Английский

Citations

8
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2969 - 2969

Published: March 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Language: Английский

Citations

1
Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells DOI

Anwesha Laha,

Simran Nasra, Dhiraj Bhatia

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(32), P. 14975 - 14993

Published: Jan. 1, 2024

Rheumatoid arthritis (RA) is a progressive autoimmune disease that mainly affects the inner lining of synovial joints and leads to chronic inflammation. While RA not known as lethal, recent research indicates it may be silent killer because its strong association with an increased risk lung heart diseases. Patients develop these systemic consequences due regular uptake heavy drugs such disease-modifying antirheumatic medications (DMARDs), glucocorticoids (GCs), nonsteroidal anti-inflammatory medicines (NSAIDs),

Language: Английский

Citations

6
3D printing incorporating gold nanozymes with mesenchymal stem cell-derived hepatic spheroids for acute liver failure treatment DOI
Yuanyuan Jin, Jiabin Zhang,

Xiaodie Chen

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122895 - 122895

Published: Oct. 19, 2024

Language: Английский

Citations

5
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery DOI
Yi Wang, Jingsong Yang, Min Zhao

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 211, P. 115355 - 115355

Published: June 5, 2024

Language: Английский

Citations

4
Effects of apples ( Malus domestica ) and their derivatives on metabolic conditions related to inflammation and oxidative stress and an overview of by-products use in food processing DOI Creative Commons
Otávio Simões Girotto,

Otávio Oliveira Furlan,

Renato Cesar Moretti

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 32

Published: July 24, 2024

Apple (Malus domestica) is the third most produced fruit worldwide. It a well-known source of bioactive compounds mainly represented by hydroxycinnamic acids, flavan-3-ols, dihydrochalcones, dehydroascorbic acid, carotenoids, chlorogenic epicatechin, and phloridzin. Due to lack recent evaluation clinical trials associated with apple consumption, this review investigated effects on metabolic conditions related inflammation oxidative stress reviewed applications waste food products. Thirty-three studies showed that apples or its derivatives exhibit anti-inflammatory antioxidant actions, improve blood pressure, body fat, insulin resistance, dyslipidemia, reduce cardiovascular risks. Apples have great economic impact due several in industry as supplement since it has impressive nutritional value. Dietary fiber from pomace can be used substitute for fat products an improver content meat also bakery confectionary fermented produce alcohol. Pomace phytocompounds isolated applied antioxidants The potential use by-products environmental damage.

Language: Английский

Citations

4
Tungsten-rosmarinic acid nanoenzyme with SOD mimetic activity for the treatment of psoriasis by eliminating ROS and relieving inflammation DOI

Chencan Su,

Yifan Zhou,

Guangquan Xu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156542 - 156542

Published: Oct. 9, 2024

Language: Английский

Citations

4