Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1321 - 1321
Published: July 4, 2022
Recent
studies
have
revealed
that
hydrogen
sulfide
(H2S)
increases
the
analgesic
actions
of
δ-opioid
receptor
(DOR)
in
inflammatory
pain.
However,
possible
improvement
analgesia
μ-opioid
(MOR)
and
DOR
agonists
during
neuropathic
pain,
through
pretreatment
with
two
slow-releasing
H2S
donors-DADS
(diallyl
disulfide)
GYY4137
(morpholin-4-ium
4-methoxyphenyl(morpholino)
phosphinodithioate
dichloromethane
complex)-is
still
unknown.
In
male
C57BL/6J
mice
pain
incited
by
chronic
constriction
sciatic
nerve
(CCI),
we
evaluated:
(1)
influence
DADS
(3.5
mg/kg)
(0.7
on
inhibition
allodynia
hyperalgesia
produced
systemic
or
local
administration
morphine
(3
mg/kg
65
µg)
UFP-512
(1
12.5
µg);
(2)
reversion
antinociceptive
high
doses
(30
(24
MOR
antagonists;
(3)
effects
donors
oxidative
stress,
apoptotic
responses,
expression
medial
septum
(MS)
dorsal
root
ganglia
(DRG).
The
results
both
improved
antiallodynic
UFP-512,
possibly
up-regulating
DRG.
antagonists
blocked
properties
GYY4137,
revealing
feasible
participation
endogenous
opioid
system
effects.
Moreover,
inhibited
stress
apoptosis
generated
CCI
MS
and/or
This
study
suggests
co-treatment
as
a
potential
therapy
for
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 10, 2024
Neuropathic
pain
(NP)
is
characterized
by
its
complex
and
multifactorial
nature
limited
responses
to
opioid
therapy;
NP
associated
with
risks
of
drug
resistance,
addiction,
difficulty
in
treatment
cessation,
psychological
disorders.
Emerging
research
on
gut
microbiota
their
metabolites
has
demonstrated
effectiveness
alleviating
augmenting
opioid-based
management,
concurrently
mitigating
the
adverse
effects
opioids.
This
review
addresses
following
key
points:
(1)
current
advances
challenges
using
opioids
treat
NP,
(2)
reciprocal
benefits
(3)
interaction
between
microbiota,
as
well
NP.
Through
various
intricate
mechanisms,
influences
onset
progression
ultimately
enhancing
efficacy
management
These
insights
pave
way
for
further
pragmatic
clinical
research,
management.
Neurobiology of Disease,
Journal Year:
2022,
Volume and Issue:
173, P. 105839 - 105839
Published: Aug. 18, 2022
Small
fibre
neuropathy
(SFN)
is
an
initial
pathology
of
diabetic
polyneuropathy
(DPN).
Serum
lipopolysaccharide
binding
protein
levels
are
positively
correlated
with
the
pain
threshold
in
foot,
suggesting
that
abundance
gut
Gram-negative
bacilli,
which
a
source
lipopolysaccharides,
may
be
involved
development
DPN.
Furthermore,
and
oral
microbiota
assumed
to
pathogenesis
diabetes.
Nevertheless,
association
between
SFN
has
not
been
clarified.
A
total
1056
individuals
were
recruited
2018
Iwaki
Health
Promotion
Project.
Pain
sensation
was
evaluated
based
on
from
intraepidermal
electrical
stimulation
(PINT).
Patients
PINT
scores
<0.15
mA
categorized
into
low-PINT
group
(n
=
718);
otherwise,
they
high-PINT
283).
each
divided
subjects
or
without
glucose
tolerance
HbA1c
levels,
fasting
blood
history.
Principal
coordinate
analysis
α-
β-diversity
evaluated.
The
correlation
clinical
data
examined.
Oral
diversity
showed
no
structural
differences
according
scores,
whereas
principal
revealed
significant
(p
<
0.01,
p
0.05
0.05,
respectively),
even
after
participants
intolerance
excluded
respectively).
relative
genus
Bacteroides
significantly
lower
compared
(10
±
6.7%
vs.
11.3
7.0%,
0.01),
exclusion
diabetes
impaired
(10.0
6.5%
11.2
6.9%,
0.05).
In
univariate
linear
regression
analyses,
metabolic
syndrome
parameters,
eGFR,
uric
acid
level
Bacteroides.
remained
adjustment
for
multiple
factors
(β
−0.07181,
Changes
bacterial
low
elevated
Japanese
population.
This
represent
new
therapeutic
option
SFN.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1726 - 1726
Published: June 15, 2023
Diabetic
neuropathy
(DN)
causes
sensory
dysfunction,
such
as
numbness,
tingling,
or
burning
sensations.
Traditional
medication
may
not
ease
pain
and
discomfort,
but
natural
remedies
Berberine
(BR)
vitamin
E
Tocopherol
(TOC)
have
therapeutic
potential
to
reduce
inflammation
while
improving
nerve
function.
Novel
substances
offer
a
more
potent
alternative
method
for
managing
severe
chronic
neuropathic
that
does
react
standard
drug
therapy
by
targeting
various
pathways
regulate
it.
Rats
with
diabetic
control
received
oral
doses
of
BR
+
TOC
showed
significant
changes
in
serum
insulin
levels
compared
DN
controls
after
90
days,
suggesting
decrease
sensitivity
painful
stimuli
partly
modulating
the
oxidative
stress
inflammatory
pathway
TNF-α
suppression
stimulation
depending
on
amount
dose
consumed
them.
NF-kB
also
played
its
role
here.
Administering
reduced
heightened
AGEs,
effectively
counteracting
inflammation-targeted
key
factors
diabetes,
promising
possibilities
benefits
these
molecules
revealed
through
vivo
investigation.
In
summary,
treating
comprehensive
organic
approach
can
involve
harnessing
powerful
capabilities
TOC.
These
compounds
been
found
only
considerably
provide
effective
protection
enhancing
overall
With
their
multifunctional
impacts
body,
naturally
occurring
an
exciting
possibility
those
who
encounter
high
distress
do
respond
well
conventional
medication-centred
therapies.
European Journal of Pharmacology,
Journal Year:
2024,
Volume and Issue:
979, P. 176818 - 176818
Published: July 18, 2024
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
is
one
of
the
most
debilitating
adverse
effects
caused
by
chemotherapy
drugs
such
as
paclitaxel,
oxaliplatin
and
vincristine.
It
untreatable
often
leads
to
discontinuation
cancer
therapy
a
decrease
in
quality
life
patients.
well-established
that
neuroinflammation
activation
immune
glial
cells
are
among
major
drivers
CIPN.
However,
these
processes
still
poorly
understood,
while
many
alone
can
drive
consequent
neuroinflammation,
it
remains
elusive
what
extent
gut
microbiome
influences
processes.
In
this
review,
we
focus
on
mechanisms
driving
CIPN,
address
bidirectional
pathways
which
communicates
with
nervous
systems.
Additionally,
critically
evaluate
literature
addressing
how
chemotherapy-induced
dysbiosis
imbalance
bacterial
products
may
contribute
cells,
both
possibly
CIPN
development,
could
use
knowledge
for
development
effective
treatment
strategies.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1321 - 1321
Published: July 4, 2022
Recent
studies
have
revealed
that
hydrogen
sulfide
(H2S)
increases
the
analgesic
actions
of
δ-opioid
receptor
(DOR)
in
inflammatory
pain.
However,
possible
improvement
analgesia
μ-opioid
(MOR)
and
DOR
agonists
during
neuropathic
pain,
through
pretreatment
with
two
slow-releasing
H2S
donors-DADS
(diallyl
disulfide)
GYY4137
(morpholin-4-ium
4-methoxyphenyl(morpholino)
phosphinodithioate
dichloromethane
complex)-is
still
unknown.
In
male
C57BL/6J
mice
pain
incited
by
chronic
constriction
sciatic
nerve
(CCI),
we
evaluated:
(1)
influence
DADS
(3.5
mg/kg)
(0.7
on
inhibition
allodynia
hyperalgesia
produced
systemic
or
local
administration
morphine
(3
mg/kg
65
µg)
UFP-512
(1
12.5
µg);
(2)
reversion
antinociceptive
high
doses
(30
(24
MOR
antagonists;
(3)
effects
donors
oxidative
stress,
apoptotic
responses,
expression
medial
septum
(MS)
dorsal
root
ganglia
(DRG).
The
results
both
improved
antiallodynic
UFP-512,
possibly
up-regulating
DRG.
antagonists
blocked
properties
GYY4137,
revealing
feasible
participation
endogenous
opioid
system
effects.
Moreover,
inhibited
stress
apoptosis
generated
CCI
MS
and/or
This
study
suggests
co-treatment
as
a
potential
therapy
for
