Abnormal intraepidermal nerve fiber density in disease: A scoping review DOI Creative Commons
Sarah Thomas, Jonathan Enders,

Andrew Kaiser

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: April 20, 2023

Intraepidermal nerve fiber density (IENFD) has become an important biomarker for neuropathy diagnosis and research. The consequences of reduced IENFD can include sensory dysfunction, pain, a significant decrease in quality life. We examined the extent to which is being used as tool human mouse models compared degree loss between diseases gain broader understanding existing data collected using this common technique.

Language: Английский

Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment DOI Creative Commons

Jinxi Zhu,

Ziyan Hu, Yifan Luo

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

Diabetic peripheral neuropathy (DPN) refers to the development of nerve dysfunction in patients with diabetes when other causes are excluded. distal symmetric polyneuropathy (DSPN) is most representative form DPN. As one common complications diabetes, its prevalence increases duration diabetes. 10-15% newly diagnosed T2DM have DSPN, and can exceed 50% for more than 10 years. Bilateral limb pain, numbness, paresthesia clinical manifestations DPN, severe cases, foot ulcers occur, even leading amputation. The etiology pathogenesis diabetic not yet completely clarified, but hyperglycemia, disorders lipid metabolism, abnormalities insulin signaling pathways currently considered be initiating factors a range pathophysiological changes In presence abnormal metabolic factors, normal structure function entire nervous system disrupted, including myelinated unmyelinated axons, perikaryon, neurovascular, glial cells. addition, pathway will inhibit neural axon repair promote apoptosis damaged Here, we discuss recent advances study DPN mechanisms, oxidative stress pathways, mechanisms microvascular damage, damage receptor potential associated neuroinflammation, mitochondrial dysfunction, cellular damage. Identifying contributions from each associations between them may help us further explore targeted screening treatment interventions.

Language: Английский

Citations

69
Advances of Schwann cells in peripheral nerve regeneration: From mechanism to cell therapy DOI Open Access

Chuqiao Wei,

Yuanxin Guo,

Zhen Ci

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116645 - 116645

Published: May 9, 2024

Peripheral nerve injuries (PNIs) frequently occur due to various factors, including mechanical trauma such as accidents or tool-related incidents, well complications arising from diseases like tumor resection. These result in persistent numbness, impaired motor and sensory functions, neuropathic pain, even paralysis, which can impose a significant financial burden on patients outcomes that often fall short of expectations. The most employed clinical treatment for PNIs involves either direct sutures the severed ends bridging proximal distal stumps using autologous grafts. However, transplantation may functional loss at donor site, neuroma formation scarring. Transplantation Schwann cells/Schwann cell-like cells has emerged promising cellular therapy reconstruct microenvironment facilitate peripheral regeneration. In this review, we summarize role recent advances cell We current techniques used therapy, injection, 3D-printed scaffolds delivery, encapsulation techniques, types experiments, experimental models, research findings. At end paper, challenges advantages (including ESCs, iPSCs, BMSCs) therapy. Our goal is provide theoretical basis future treatments targeting nerves, highlighting potential tissue engineering invaluable resources promoting

Language: Английский

Citations

26
Reduce electrical overload via threaded Chinese acupuncture in nerve electrical therapy DOI Creative Commons
Yupu Liu, Yawei Du, Juan Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 476 - 493

Published: Jan. 5, 2025

Language: Английский

Citations

2
Inflammation in the Peripheral Nervous System after Injury DOI Creative Commons

Dandan Gu,

Yiming Xia,

Zihan Ding

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1256 - 1256

Published: June 5, 2024

Nerve injury is a common condition that occurs as result of trauma, iatrogenic injury, or long-lasting stimulation. Unlike the central nervous system (CNS), peripheral (PNS) has strong capacity for self-repair and regeneration. Peripheral nerve results in degeneration distal axons myelin sheaths. Macrophages Schwann cells (SCs) can phagocytose damaged cells. Wallerian (WD) makes whole axon structure degenerate, creating favorable regenerative environment new axons. After macrophages, neutrophils other are mobilized recruited to site necrotic debris. Pro-inflammatory anti-inflammatory factors involved inflammatory response provide microenvironment regeneration regulate effects inflammation on body through relevant signaling pathways. Previously, was thought be detrimental body, but further research shown appropriate promotes regeneration, formation. On contrary, excessive cause tissue damage pathological changes, even lead neurological diseases. Therefore, after various interact with cytokines chemokines promote repair by inhibiting negative harnessing positive specific ways at times. Understanding interaction between neuroinflammation provides several therapeutic ideas improve

Language: Английский

Citations

15
The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties DOI Open Access
Sonia Gavasso, Torbjørn Kråkenes,

Håkon Olsen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1365 - 1365

Published: Jan. 23, 2024

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within central nervous system (CNS) and promote remyelination regeneration. Mesenchymal stem cells (MSCs) represent promising therapeutic option, as they have been shown migrate site of CNS injury exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, endogenous neural cell stimulation. This review summarizes current understanding underlying mechanisms discusses translation MSC transplantation their derivatives from pre-clinical demyelinating models clinical trials MS patients.

Language: Английский

Citations

11
Schwann Cell Development and Myelination DOI
James L. Salzer, M. Laura Feltri, Claire Jacob

et al.

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(9), P. a041360 - a041360

Published: March 19, 2024

Glial cells in the peripheral nervous system (PNS), which arise from neural crest, include axon-associated Schwann (SCs) nerves, synapse-associated SCs at neuromuscular junction, enteric glia, perikaryon-associated satellite ganglia, and boundary cap border between central (CNS) PNS. Here, we focus on SCs. These progress through a series of formative stages, culminate generation myelinating that wrap large-caliber axons nonmyelinating (Remak) enclose multiple, small-caliber axons. In this work, describe SC development, extrinsic signals axon extracellular matrix (ECM) intracellular signaling pathways they activate regulate morphogenesis organization myelin sheath. We review impact biology integrity their emerging role regulating nerve architecture. Finally, explain how transcription epigenetic factors control fine-tune development myelination.

Language: Английский

Citations

10
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies DOI
Ruth M. Stassart, Jose A. Gomez‐Sanchez, Alison C. Lloyd

et al.

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(6), P. a041363 - a041363

Published: Jan. 10, 2024

Ruth M. Stassart1, Jose A. Gomez-Sanchez2,3 and Alison C. Lloyd4 1Paul-Flechsig-Institute of Neuropathology, University Clinic Leipzig, Leipzig 04103, Germany 2Instituto de Investigación Sanitaria y Biomédica Alicante (ISABIAL), 03010, Spain 3Instituto Neurociencias CSIC-UMH, Sant Joan 03550, 4UCL Laboratory for Molecular Cell Biology, College London, London WC1E 6BT, United Kingdom Correspondence: alison.lloyd{at}ucl.ac.uk

Language: Английский

Citations

9
Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration DOI
Xueying Zhao, Hui Deng, Yuan Feng

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(9), P. 2217 - 2235

Published: Jan. 1, 2024

Effective immune response is an indispensable process for peripheral nerve regeneration and the tissue engineering strategies provide approach regulating cells that promote repair.

Language: Английский

Citations

9
Interactions between Schwann cell and extracellular matrix in peripheral nerve regeneration DOI Creative Commons

Maorong Jiang,

Muyang Chen,

Nana Liu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: March 26, 2024

Peripheral nerve injuries, caused by various reasons, often lead to severe sensory, motor, and autonomic dysfunction or permanent disability, posing a challenging problem in regenerative medicine. Autologous transplantation has been the gold standard traditional treatments but faces numerous limitations risk factors, such as donor area denervation, increased surgical complications, diameter bundle mismatches. The extracellular matrix (ECM) is complex molecular network synthesized released into space cells residing tissues organs. Its main components include collagen, proteoglycans/glycosaminoglycans, elastin, laminin, fibronectin, etc., providing structural biochemical support surrounding cells, crucial for cell survival growth. Schwann primary glial peripheral nervous system, play important roles. considered therapy making ECM derived from one of most suitable biomaterials repair. To better understand mechanisms regeneration their optimal application, this review provides an overview roles regeneration.

Language: Английский

Citations

9
Schwann Cells in Neuromuscular Disorders: A Spotlight on Amyotrophic Lateral Sclerosis DOI Creative Commons
Kathryn R. Moss, Smita Saxena

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 47 - 47

Published: Jan. 3, 2025

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease primarily affecting motor neurons, leading to progressive muscle atrophy and paralysis. This review explores the role of Schwann cells in ALS pathogenesis, highlighting their influence on progression through mechanisms involving demyelination, neuroinflammation, impaired synaptic function. While have been traditionally viewed as peripheral supportive cells, especially neuron disease, recent evidence indicates that they play significant by impacting survival plasticity, influencing inflammatory responses, altering myelination processes. Furthermore, advancements understanding cell pathology combined with lessons learned from studying Charcot–Marie–Tooth Type 1 (CMT1) suggest potential therapeutic strategies targeting these may support nerve repair slow progression. Overall, this aims provide comprehensive insights into classification, physiology, function, underscoring critical pathological contributions suggests new avenues for targeted interventions aimed at modulating function ALS.

Language: Английский

Citations

1