Mitigative effect of sodium alginate on streptozotocin (STZ)-induced diabetic neuropathy through regulation of redox status and miR-146a in the rat sciatic nerve DOI Creative Commons
Nema A. Mohamed,

Naeimah M. Shouran,

Amina E. Essawy

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19046 - e19046

Published: March 24, 2025

Diabetic peripheral neuropathy (DPN) is a significant complication of diabetes with limited effective therapeutic options. Sodium alginate (SA), natural polysaccharide from brown algae, has demonstrated health benefits, however, whether it can treat streptozotocin (STZ)-induced DPN remains unclear. The present experiment aimed to test the preventive role SA on STZ-induced in rats and explored possible mechanisms. rat model was established by intraperitoneal injection single dose 40 mg/kg b.w. STZ, (200 b.w./day) orally administered for 28 days after type 2 mellitus (T2DM) induction. obtained findings revealed that STZ significantly increased serum levels FBG, HOMA-IR, TC, TG, VLDL-C, LDL-C, while decreased insulin, incretin GLP-1, HDL-C, lipase activity. In sciatic nerves, proinflammatory cytokine (IL-1β, IL-6, TNF-α), caspase-3 (a pro-apoptotic protein), markers oxidative stress (MDA NO), AGEs. parallel, induced decline activities enzymatic antioxidants, viz. , SOD, CAT, GPx, non-enzymatic GSH. These changes were accompanied low expression miR-146a nerves rats. Except treatment injected improved these parameters helped rescue neurological morphology nerve fibers. conclusion, mitigated experimental DPN, this might be due its ability suppress hyperglycemic-hyperlipidemic effects, counteract overactivation inflammatory molecules, increase expression, modulate dysregulation, reduce cell apoptosis.

Language: Английский

Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies DOI
Aditi Singh,

Sucharita Shadangi,

Pulkit Kr. Gupta

et al.

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management

Language: Английский

Citations

1
Study on the active ingredients and molecular mechanisms of Polygonatum sibiricum beverage in the intervention of type 2 diabetes mellitus based on UPLC-MS, network pharmacology and experimental validation DOI Creative Commons
M. Q. Ruan,

Qiu-xiao Ai,

G. F. Cao

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106762 - 106762

Published: April 1, 2025

Language: Английский

Citations

1
Advances in fecal microbiota transplantation for the treatment of diabetes mellitus DOI Creative Commons
Juan Zhang, Honggang Wang, Ying Liu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm organ systems and lead acute or complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy drugs insulin; however, some patients still find satisfactory curative effect difficult achieve. Extensive research has demonstrated close correlation between enteric dysbacteriosis the pathogenesis types DM, paving way for novel therapeutic approaches targeting gut microbiota manage DM. Fecal transplantation (FMT), method re-establishing intestinal microbiome balance, offers new possibilities treating diabetes. This article provides comprehensive review microbiota, as well current advancements in FMT using an illustrative example. study aims offer perspectives establish theoretical foundation clinical diagnosis management

Language: Английский

Citations

5
Investigating the Interplay between Mitophagy and Diabetic Neuropathy: Uncovering the hidden secrets of the disease pathology DOI Creative Commons
Kiavash Hushmandi, Behzad Einollahi,

Rachel Aow

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107394 - 107394

Published: Sept. 3, 2024

Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a crucial role in maintaining metabolic balance and preventing insulin resistance, both key factors type 2 diabetes mellitus (T2DM) development. When mitophagy malfunctions diabetic neuropathy, it triggers cascade disruptions, including reduced energy production, increased oxidative stress, cell death, ultimately leading to various complications. Thus, targeting enhance may have emerged as promising therapeutic strategy for T2DM its Notably, plant-derived compounds with β-cell protective mitophagy-stimulating properties offer potential novel agents. This review highlights intricate mechanisms linking dysfunction complications, particularly elucidating interventions this debilitating disease.

Language: Английский

Citations

5
Development of ovalbumin implants with different spatial configurations for treatment of peripheral nerve injury DOI Creative Commons
Tiantian Zheng, Hongxia Gao, Yaqiong Liu

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 401 - 415

Published: Feb. 15, 2024

Peripheral nerve injury (PNI) seriously affects the health and life of patients, is an urgent clinical problem that needs to be resolved. Nerve implants prepared from various biomaterials have played a positive role in PNI, but effect should further improved thus new urgently needed. Ovalbumin (OVA) contains variety bioactive components, low immunogenicity, tolerance, antimicrobial activity, non-toxicity biodegradability, has ability promote wound healing, cell growth properties. However, there are few studies on application OVA neural tissue engineering. In this study, with different spatial structures (membrane, fiber, lyophilized scaffolds) were constructed by casting, electrospinning, freeze-drying methods, respectively. The results showed had excellent physicochemical properties biocompatible without significant toxicity, can vascularization, show good histocompatibility, excessive inflammatory response immunogenicity. vitro could proliferation migration Schwann cells, while vivo confirmed (the E5/70% 20 kV μL/min groups) effectively regulate blood vessels, reduce repair subcutaneous injury. Further on, high-throughput sequencing up-regulated differential expression genes related biological processes such as tumor necrosis factor-α (TNF-α), phosphatidylinositide 3-kinases/protein kinase B (PI3K-Akt) signaling pathway, axon guidance, cellular adhesion junctions, regeneration cells. present study expected provide design concepts theoretical accumulation for development generation implantable biomaterials.

Language: Английский

Citations

4
Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy DOI Creative Commons
Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1390 - 1390

Published: June 23, 2024

Diabetic neuropathy (DN) is a neurodegenerative disorder that primarily characterized by distal sensory loss, reduced mobility, and foot ulcers may potentially lead to amputation. The multifaceted etiology of DN linked range inflammatory, vascular, metabolic, other factors. Chronic inflammation, endothelial dysfunction, oxidative stress are the three basic biological changes contribute development DN. Although our understanding intricacies has advanced significantly over past decade, distinctive mechanisms underlying condition still poorly understood, which be reason behind lack an effective treatment cure for present study delivers comprehensive highlights potential role several pathways molecular etiopathogenesis Moreover, Schwann cells satellite glial cells, as integral factors in pathogenesis DN, have been enlightened. This work will motivate allied research disciplines gain better analysis current state biomolecular essential effectively address every facet from prevention treatment.

Language: Английский

Citations

4
Application of NerveCheck Master in the Diagnosis of Diabetic Peripheral Neuropathy DOI Creative Commons

Raquel García de la Peña,

Mercedes Ortiz-Romero,

José María Juárez Jiménez

et al.

Diabetology, Journal Year: 2025, Volume and Issue: 6(1), P. 3 - 3

Published: Jan. 2, 2025

Backgraund/Objetive: Diabetic peripheral neuropathy is a condition that affects the motor, sensory, and autonomic fibers of nervous system, with distal polyneuropathy being its most common form. Traditional methods for diagnosing sensory loss, such as tactile assessment, temperature evaluation, vibratory perception threshold testing, are labor intensive time consuming. Results: To effectively assess thermal sensitivity, NerveCheck Master an affordable portable device uses standardized stimuli to measure response. Conclusions: Compared traditional like infrared laser thermometer, Rydel–Seiffer tuning fork, Semmes–Weinstein monofilament, this provides definitive results regarding severity DPN.

Language: Английский

Citations

0
An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia DOI
Bahman Jabbari,

Ava Tohidian

Toxicon, Journal Year: 2025, Volume and Issue: 255, P. 108237 - 108237

Published: Jan. 10, 2025

Language: Английский

Citations

0
Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review DOI Creative Commons
Xiaoli Liu,

Sailu Mao,

Yuxue Yuan

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Diabetic cognitive dysfunction is one of the important comorbidities and complications diabetes, which mainly manifested by loss learning ability memory, behavioural disorders, may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition long-term use these can be accompanied undesirable side effects. Therefore, there an urgent need to find safe alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play role regulation diabetes. In this review, we explored relationship between diabetes mellitus dysfunction, potential underlying mechanisms plant-derived improve diabetic dysfunction. We found active alleviate impairment inhibiting key enzymes (e.g., α-glucosidase, α-amylase) blood glucose levels increase antioxidant activity, modulate inflammatory mediators, address intestinal dysbiosis. conclusion, show strong impairment.

Language: Английский

Citations

0
Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats DOI Creative Commons
Jin Ran,

Hailuan Pei,

Feng Yue

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 325 - 347

Published: Jan. 1, 2025

This study aims to explore the mechanism of Yangxuerongjin pill (YXRJP) in treatment diabetic peripheral neuropathy (DPN) by network pharmacology and metabolomics technology combined with animal experiments, provide scientific basis for DPN. In this study, analysis was applied identify active compounds, core targets signal pathways, which might be responsible effect The DPN model established high-fat diet streptozotocin (STZ) injection, rats were given administration 12 weeks. body weight, thermal withdrawal latency (TWL), sciatic motor nerve conduction velocity (MNCV), biochemical indexes, pathological sections nerve, oxidative stress factors expression levels neuroprotection-related proteins detected. Metabolomics used analyze potential biomarkers metabolic pathways treated YXRJP. results showed that YXRJP could treat through baicalin, β-sitosterol, 7-methoxy-2-methylisoflavone, aloe-emodin luteolin on insulin resistance, Toll-like receptor (TLR), tumor necrosis factor (TNF) other signaling pathways. can prolong TWL, increase MNCV alleviate injury reduce triglyceride (TG), improve Insulin-like growth 1 (IGF-1) protein kinase B (AKT) protein. mainly involved amino acid metabolism such as arginine, alanine, aspartic acid, lipid nucleotide metabolism. effectively symptoms damage. effects are related reducing injury, promoting proteins, inflammation-related affecting metabolism, Our findings revealed has a good therapeutic DPN, provides reference further studies

Language: Английский

Citations

0