Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
9Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106573 - 106573
Published: June 18, 2024
Arketamine, the (R)-enantiomer of ketamine, exhibits antidepressant-like effects in mice, though precise molecular mechanisms remain elusive. It has been shown to reduce splenomegaly and depression-like behaviors chronic social defeat stress (CSDS) model depression. This study investigated whether spleen contributes arketamine CSDS model. We found that splenectomy significantly inhibited arketamine's CSDS-susceptible mice. RNA-sequencing analysis identified oxidative phosphorylation (OXPHOS) pathway prefrontal cortex (PFC) as a key mediator splenectomy's impact on effects. Furthermore, oligomycin A, an inhibitor OXPHOS pathway, reversed suppressive Specific genes within pathways, such COX11, UQCR11 ATP5e, may contribute these inhibitory Notably, transforming growth factor (TGF)-β1, along with appears modulate Additionally, SRI-01138, agonist TGF-β1 receptor, alleviated Subdiaphragmatic vagotomy also counteracted These findings suggest PFC play significant roles arketamine, mediated through spleen-brain axis via vagus nerve.
Language: Английский
Citations
7Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106570 - 106570
Published: June 15, 2024
Hepatic lipoprotein receptor-related protein 1 (LRP-1) plays a central role in peripheral amyloid beta (Aβ) clearance, but its importance Alzheimer's disease (AD) pathology is understudied. Our previous work showed that intragastric alcohol feeding to C57BL/6 J mice reduced hepatic LRP-1 expression which correlated with significant AD-relevant brain changes. Herein, we examined the of AD pathogenesis APP/PS1 using two approaches modulate LRP-1, model chronic heavy drinking shown by us reduce and hepato-specific silencing.
Language: Английский
Citations
5Endurance Exercise Training Alleviates Hepatic Lipocalin‐2 Release and Prevents Anxiety‐Like Disorders in Chronically Stressed Mice
Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract Exercise training can prevent anxiety disorders in both rodent models and human cohorts. The involvement of peripheral factors exercise‐mediated mental health is being appreciated. It recently shown that the hepatic biosynthesis lipocalin‐2 (LCN2) respond to chronic restraint stress (CRS) elicit anxiety‐like behaviors via inhibiting neural activity medial prefrontal cortex (mPFC). Here, it found 14‐day treadmill exercise ameliorates these CRS‐treated mice. Further assays show intervention reduces release LCN2. Meanwhile, may also counteract adverse effect LCN2 relieving cortical microglial cell proliferation. results collectively suggest modulate liver‐brain axis reshape for preventing disorders.
Language: Английский
Citations
0Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106666 - 106666
Published: Sept. 1, 2024
Language: Английский
Citations
2Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen–gut–brain axis
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 114 - 125
Published: June 27, 2024
Language: Английский
Citations
2The Vagus Nerve and the Brain-Gut Axis: Implications for Neuropsychiatric Disorders
Journal of Neuropsychiatry, Journal Year: 2024, Volume and Issue: 36(4), P. 278 - 282
Published: Oct. 1, 2024
Language: Английский
Citations
2Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso‐logistic regression and decision tree models
Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(8)
Published: Aug. 1, 2024
Depressive symptoms are frequently observed in patients with primary biliary cholangitis (PBC). The role of depressive on cirrhosis has not been fully noticed PBC. We aimed to establish a risk model for that took into account.
Language: Английский
Citations
1Soluble epoxide hydrolase: Mechanisms and therapeutic potential in psychiatric and neurological disorders
Advances in pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 237 - 266
Published: Oct. 16, 2024
Language: Английский
Citations
1Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors
AJP Gastrointestinal and Liver Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. G850 - G860
Published: Oct. 29, 2024
This study explores how exercise affects liver fibrosis-related anxiety in mice. Researchers found that regular reversed carbon tetrachloride (CCl 4 )-induced fibrosis and reduced anxiety, even mice with fibrosis. Exercise increased brain-derived neurotrophic factor (BDNF) decreased neuronal nitric oxide synthase (nNOS) the hippocampus. These findings suggest has therapeutic potential for treating associated chronic disease by modulating specific brain factors.
Language: Английский
Citations
1