Drop to Gate Nasal Drops Attenuates Sepsis‐Induced Cognitive Dysfunction DOI
Yaping Zhuang,

Xiyu Du,

Li Yang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 5, 2024

Nasal administration can bypass the blood-brain barrier and directly deliver drugs to brain, providing a non-invasive route for central nervous system (CNS) diseases. Inspired by appearance that gate block outside world characteristics of sol-gel transition form "gate" in nasal cavity, Drop Gate drop (DGND) is designed set nose, which achieves protecting role from influence environment. The DGND demonstrates efficiency application prospect delivering brain through N-to-B. effective concentration single increased hydrophobic interaction between C

Language: Английский

The vagus nerve: An old but new player in brain–body communication DOI Creative Commons
Li Ma,

Hanbing Wang,

Kenji Hashimoto

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

9
Gut-brain connection in schizophrenia: A narrative review DOI
Asma Iqbal, Syed Faqeer Hussain Bokhari,

Muneeb Ur Rehman

et al.

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 30, 2025

Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive, emotional, and behavioral impairments. The microbiota-gut-brain axis crucial in its pathophysiology, mediating communication between the gut brain through neural, immune, endocrine, metabolic pathways. Dysbiosis, or an imbalance microbiota, linked to neuroinflammation, systemic inflammation, neurotransmitter disruptions, all of which contribute symptoms schizophrenia. Gut microbiota-derived metabolites, such as short-chain fatty acids, influence function, including immune responses synthesis. These findings suggest that microbial imbalances exacerbate schizophrenia, providing novel perspective on disorder’s underlying mechanisms. Emerging microbiota-targeted therapies—such probiotics, prebiotics, dietary interventions, fecal microbiota transplantation—show promise adjunctive treatments, aiming restore balance improve clinical outcomes. While further research needed, targeting offers innovative approach schizophrenia management, with potential enhance patient outcomes quality life.

Language: Английский

Citations

0
Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases” DOI Creative Commons
Kenji Hashimoto, Wei Yan, Chun Yang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106666 - 106666

Published: Sept. 1, 2024

Language: Английский

Citations

2
Exploring the Potential of Probiotics in Alzheimer's disease and Gut Dysbiosis DOI Creative Commons

S. Sowmiya,

D. S.,

P. Rajendran

et al.

IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: 17, P. 441 - 455

Published: Nov. 8, 2024

Language: Английский

Citations

2
Drop to Gate Nasal Drops Attenuates Sepsis‐Induced Cognitive Dysfunction DOI
Yaping Zhuang,

Xiyu Du,

Li Yang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 5, 2024

Nasal administration can bypass the blood-brain barrier and directly deliver drugs to brain, providing a non-invasive route for central nervous system (CNS) diseases. Inspired by appearance that gate block outside world characteristics of sol-gel transition form "gate" in nasal cavity, Drop Gate drop (DGND) is designed set nose, which achieves protecting role from influence environment. The DGND demonstrates efficiency application prospect delivering brain through N-to-B. effective concentration single increased hydrophobic interaction between C

Language: Английский

Citations

0