Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases” DOI Creative Commons
Kenji Hashimoto, Wei Yan, Chun Yang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106666 - 106666

Published: Sept. 1, 2024

Language: Английский

The vagus nerve: An old but new player in brain–body communication DOI Creative Commons
Li Ma,

Hanbing Wang,

Kenji Hashimoto

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

10
Preoperative inflammatory pain exacerbates postoperative pain and neurocognitive impairment DOI Creative Commons
Hui Yuan, Daofan Sun, Bo Lu

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Many studies have shown that postoperative pain aggravates perioperative neurocognitive disorder (PND). In this study we aimed to clarify the effect of preoperative inflammatory on and cognitive function. We established model by injected complete freund adjuvant (CFA) PND tibial fracture surgery in 14- month-old C57BL/6 mice. The paw withdrawal threshold body weight mice were measured 7 days before 3 after surgery. On third day, subjected behavioral testing or sacrificed collect brain tissue. result shows CFA exacerbated dysfunction mice, enhanced surgery-induced activation microglia astrocytes hippocampus, increased overexpression IL-1β, IL-6, TNF-α, as well aggravated decreased expression α7nAChR HMGB1 hippocampus induced Our further aged rats, mechanism may be related neuroinflammation caused α7nAChR-mediated CAP high release HMGB1.

Language: Английский

Citations

0
Vagal Sensory Gut–Brain Pathways That Control Eating—Satiety and Beyond DOI
Rebeca Méndez‐Hernández,

Isadora Braga,

Avnika Bali

et al.

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 1, 2025

ABSTRACT The vagus nerve is the body's primary sensory conduit from gut to brain, traditionally viewed as a passive relay for satiety signals. However, emerging evidence reveals far more complex system—one that actively encodes diverse aspects of meal‐related information, mechanical stretch nutrient content, metabolic state, and even microbial metabolites. This review challenges view vagal afferent neurons (VANs) simple meal‐termination sensors highlights their specialized subpopulations, modalities, downstream brain circuits, which shape feeding behavior, metabolism, cognition. We integrate recent advances single‐cell transcriptomics, neural circuit mapping, functional imaging examine how VANs contribute gut–brain communication beyond satiety, including roles in food reward memory formation. By synthesizing latest research highlighting directions field, this provides comprehensive update on pathways role integrators meal information.

Language: Английский

Citations

0
Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases” DOI Creative Commons
Kenji Hashimoto, Wei Yan, Chun Yang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106666 - 106666

Published: Sept. 1, 2024

Language: Английский

Citations

2