A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis DOI Creative Commons
Lisha Chang, Jie Ding, Juan Pu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: July 4, 2024

Metastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis a crucial factor tumor invasion metastasis. Long noncoding RNAs (lncRNAs) play regulatory functions various biological processes cells, however, roles lncRNAs CRC-associated remain to be elucidated CRC, as do underlying mechanisms. We used bioinformatics screen differentially expressed from TCGA database. LOC101928222 expression was assessed by qRT-PCR. The impact CRC development both vitro vivo. mechanisms were investigated cellular fractionation, RNA-sequencing, mass spectrometric, RNA pull-down, immunoprecipitation, stability, gene-specific m6A assays. upregulated correlated worse outcome. Moreover, shown promote migration, invasion, CRC. Mechanistically, synergized IGF2BP1 stabilize HMGCS2 mRNA through an m6A-dependent pathway, increased cholesterol synthesis and, ultimately, promotion development. In summary, these findings demonstrate novel, LOC101928222-based mechanism involved regulation metastatic potential LOC101928222-HMGCS2-cholesterol pathway may effective target for diagnosing managing

Language: Английский

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer’s disease DOI
Nourhan M. Abdelmaksoud, Al-Aliaa M. Sallam, Ahmed I. Abulsoud

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155007 - 155007

Published: Dec. 4, 2023

Language: Английский

Citations

23
miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma DOI
Tohada M. AL‐Noshokaty, Mohammed S. Elballal,

Gouda K. Helal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154763 - 154763

Published: Aug. 14, 2023

Language: Английский

Citations

21
The interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences DOI
Ahmed S. Doghish, Mohamed A. Ali, Mahmoud A. Elrebehy

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 250, P. 154790 - 154790

Published: Sept. 6, 2023

Language: Английский

Citations

18
The lncRNAs UCA1 and CRNDE target miR-145/TLR4/NF-қB/TNF-α axis in acetic acid-induced ulcerative colitis model: The beneficial role of 3,3-Diindolylmethane DOI
Noha A. El-Boghdady,

Shrook Abd El-Hakk,

Mai A. Abd‐Elmawla

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110541 - 110541

Published: June 28, 2023

Language: Английский

Citations

17
A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis DOI Creative Commons
Lisha Chang, Jie Ding, Juan Pu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: July 4, 2024

Metastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis a crucial factor tumor invasion metastasis. Long noncoding RNAs (lncRNAs) play regulatory functions various biological processes cells, however, roles lncRNAs CRC-associated remain to be elucidated CRC, as do underlying mechanisms. We used bioinformatics screen differentially expressed from TCGA database. LOC101928222 expression was assessed by qRT-PCR. The impact CRC development both vitro vivo. mechanisms were investigated cellular fractionation, RNA-sequencing, mass spectrometric, RNA pull-down, immunoprecipitation, stability, gene-specific m6A assays. upregulated correlated worse outcome. Moreover, shown promote migration, invasion, CRC. Mechanistically, synergized IGF2BP1 stabilize HMGCS2 mRNA through an m6A-dependent pathway, increased cholesterol synthesis and, ultimately, promotion development. In summary, these findings demonstrate novel, LOC101928222-based mechanism involved regulation metastatic potential LOC101928222-HMGCS2-cholesterol pathway may effective target for diagnosing managing

Language: Английский

Citations

7