Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study DOI Open Access
Eva Dohle, Ling Zhu, Robert Sader

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12983 - 12983

Published: Dec. 3, 2024

Nonmelanoma skin cancer (NMSC) presents a significant challenge to global healthcare due its rising incidence, prompting the search for innovative treatments overcome limitations of current therapies. Our study aims explore potential effects liquid blood concentrate platelet-rich fibrin (PRF) on basal cell carcinoma cells (BCCs) and squamous (SCCs) in order obtain results that may lead new possible adjunctive therapies managing localized cancers, particularly NMSC. Basal (BCC) (SCC) were indirectly treated with PRF generated via different relative centrifugation forces, namely high low RCF PRF, 7 days. PRF-treated comparatively analyzed viability, proliferation cycle- apoptosis-related gene expression. Analysis MTS assay revealed decrease viability both BCC SCC following treatment Ki-67 staining showed decreased percentage Ki-67-positive after 2 days compared control group. The downregulation CCND1 expression types at along upregulation p21 p53 demonstrated effect inhibiting inducing cycle arrest, especially during initial phases treatment. Increased caspase-8 caspase-9 was observed, indicating activation extrinsic intrinsic apoptotic pathways by Although exact immunomodulatory properties require further investigation, our basic vitro studies are promising might provide basis future investigations as an therapy

Language: Английский

Understanding the charismatic potential of nanotechnology to treat skin carcinoma DOI

Aamravi Sathe,

Bhupendra G. Prajapati, Sankha Bhattacharya

et al.

Medical Oncology, Journal Year: 2023, Volume and Issue: 41(1)

Published: Dec. 19, 2023

Language: Английский

Citations

1
Advances in Skin Cancer DOI
Jenan Al‐Matouq

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Skin cancer has been associated with excessive sun exposure ever since the nineteenth century. The most common affected skin cells upon recurrent to include squamous cells, basal and Merkel cells. Basal cell carcinoma highest prevalence among other types of cancer, but rarely metastasizes is highly treatable. Squamous carcinoma, if left untreated, inclined penetrate epidermis, invade into dermis, metastasize organs. Melanoma, however, aggressive least survival rates. Cumulative ultraviolet radiation mainly from results in DNA damage, oxidative stress, inflammatory response, gene mutations, all leading development cancer. Many molecular pathways are by mutations can activate oncogenes, inactivate tumor suppressor genes, or impair repair genes. This consequently lead increased proliferation, blood vessel growth, invasion, evasion immune ultimately, metastasis. Early detection vital prevent promotion via histopathological techniques. Treatment options surgical removal as first-line treatment for early stages therapy. An alternative emerging approach metastasized through nanotechnology that operates at a nanoscale increasing drug delivery distribution body.

Language: Английский

Citations

0
Novel Copper Complex Inhibits the Proteasome in Skin Squamous Cell Carcinoma Induced by DMBA in Mice DOI
Ouadie Mohamed El Yaagoubi, Larbi Oularbi, Ouissal Salhi

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127533 - 127533

Published: Sept. 18, 2024

Language: Английский

Citations

0
Obrabotka spektrov kombinatsionnogo rasseyaniya sveta novoobrazovaniy kozhi metodom lorentsevoy approksimatsii: pilotnye issledovaniya DOI
И. Н. Сараева, Elena Rimskaya, A.B. Timurzieva

et al.

Письма в Журнал экспериментальной и теоретической физики, Journal Year: 2024, Volume and Issue: 119(7-8), P. 552 - 559

Published: Sept. 25, 2024

Citations

0
Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study DOI Open Access
Eva Dohle, Ling Zhu, Robert Sader

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12983 - 12983

Published: Dec. 3, 2024

Nonmelanoma skin cancer (NMSC) presents a significant challenge to global healthcare due its rising incidence, prompting the search for innovative treatments overcome limitations of current therapies. Our study aims explore potential effects liquid blood concentrate platelet-rich fibrin (PRF) on basal cell carcinoma cells (BCCs) and squamous (SCCs) in order obtain results that may lead new possible adjunctive therapies managing localized cancers, particularly NMSC. Basal (BCC) (SCC) were indirectly treated with PRF generated via different relative centrifugation forces, namely high low RCF PRF, 7 days. PRF-treated comparatively analyzed viability, proliferation cycle- apoptosis-related gene expression. Analysis MTS assay revealed decrease viability both BCC SCC following treatment Ki-67 staining showed decreased percentage Ki-67-positive after 2 days compared control group. The downregulation CCND1 expression types at along upregulation p21 p53 demonstrated effect inhibiting inducing cycle arrest, especially during initial phases treatment. Increased caspase-8 caspase-9 was observed, indicating activation extrinsic intrinsic apoptotic pathways by Although exact immunomodulatory properties require further investigation, our basic vitro studies are promising might provide basis future investigations as an therapy

Language: Английский

Citations

0