Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence DOI Creative Commons
Cheryl M. McCormick,

Matthew R. Green,

Jonathan J. Simone

et al.

Neurobiology of Stress, Journal Year: 2016, Volume and Issue: 6, P. 31 - 43

Published: Sept. 5, 2016

Elevations in glucocorticoids that result from environmental stressors can have programming effects on brain structure and function when the exposure occurs during sensitive periods involve heightened neural development. In recent years, adolescence has gained increasing attention as another period of development, a which pubertal transitions may increase vulnerability to stressors. There are similarities physical behavioural development between humans rats, rats been used effectively an animal model unique plasticity this ontogeny. This review focuses benefits challenges for translational research hypothalamic-pituitary-adrenal (HPA) adolescence, highlighting important parallels contrasts adolescent humans, we main stress procedures investigating HPA responses their consequences rats. We conclude greater focus timing puberty factor relevance findings.

Language: Английский

Animal models of major depression: drawbacks and challenges DOI Creative Commons

Barbara Planchez,

Alexandre Surget, Catherine Belzung

et al.

Journal of Neural Transmission, Journal Year: 2019, Volume and Issue: 126(11), P. 1383 - 1408

Published: Oct. 4, 2019

Major depression is a leading contributor to the global burden of disease. This situation mainly related chronicity and/or recurrence disorder, and poor response antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating environment which rodents exposed (during developmental period or adulthood) biological underpinnings (i.e. gene deletion overexpression candidate genes, targeted lesions brain areas, optogenetic control specific neuronal populations, etc.). These manipulations can alter behavioural outcomes that be different symptomatic pathophysiological dimensions major depression. However, display substantial shortcomings contribute lack innovative pharmacological approaches recent decades hamper our capabilities investigate treatment-resistant Here, we discuss validity these models, review putative depression, subtypes recurrent Furthermore, identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical

Language: Английский

Citations

358
Neurobiology of Resilience: Interface Between Mind and Body DOI
Flurin Cathomas, James W. Murrough, Eric J. Nestler

et al.

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(6), P. 410 - 420

Published: April 17, 2019

Language: Английский

Citations

245
Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation DOI Creative Commons
Jessica Deslauriers, Máté Tóth,

Andre Der‐Avakian

et al.

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 83(10), P. 895 - 907

Published: Nov. 21, 2017

Language: Английский

Citations

217
Migration and psychosis: a meta-analysis of incidence studies DOI Creative Commons
Jean-Paul Selten, E. van der Ven, Fabian Termorshuizen

et al.

Psychological Medicine, Journal Year: 2019, Volume and Issue: 50(2), P. 303 - 313

Published: Feb. 6, 2019

The aims of this meta-analysis are (i) to estimate the pooled relative risk (RR) developing non-affective psychotic disorder (NAPD) and affective (APD) among migrants their children; (ii) adjust these results for socioeconomic status (SES); (iii) examine sources heterogeneity that underlie NAPD.We included population-based incidence studies reported an age-adjusted RR with 95% confidence interval (CI) published 1 January 1977-12 October 2017 used a random-effects model.We retrieved performed in Europe (n = 43), Israel 3), Canada 2) Australia 1). yielded RR, adjusted age sex, 2.13 (95% CI 1.99-2.27) NAPD 2.94 2.28-3.79) APD. RRs diminished, but persisted after adjustment SES. With reference NAPD: personal or parental history migration from countries outside was associated higher (RR 2.94, 2.63-3.29) than within 1.88, 1.62-2.18). corresponding lower 1.22; 0.99-1.50) 1.21; 0.85-1.74). highest individuals black skin colour 4.19, 3.42-5.14). evidence difference between first second generation insufficient.Positive selection may explain low Canada, while change exclusion inclusion do same Israel. Given high risks Europe, social have pathogenic role.

Language: Английский

Citations

189
Rodent models of post-traumatic stress disorder: behavioral assessment DOI Creative Commons
Alexander Verbitsky, David Dopfel, Nanyin Zhang

et al.

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 6, 2020

Although the etiology and expression of psychiatric disorders are complex, mammals show biologically preserved behavioral neurobiological responses to valent stimuli which underlie use rodent models post-traumatic stress disorder (PTSD). PTSD is a complex phenotype that difficult model in rodents because it diagnosed by patient interview influenced both environmental genetic factors. However, given results from traumatic experiences, can simulate induction development. By manipulating type, intensity, duration, frequency, preclinical reflect core phenotypes, measured through various assays. Paradigms precipitate applying physical, social, psychological stressors individually or combination. This review discusses methods used trigger evaluate PTSD-like phenotypes. It highlights studies employing each evaluates their translational efficacies against DSM-5, validity criteria, criteria proposed Yehuda Antelman's commentary 1993. intended aid paradigm selection informing readers about models, benefits clinical community, challenges associated with opportunities for future work. To inform relevance human psychopathology, we propose incorporate test batteries, individual differences, sex strain stock early life effects, biomarkers, stringent success drug development, Research Domain Criteria, technological advances, cross-species comparisons. We conclude that, despite challenges, animal will be pivotal advances understanding neurobiology stress.

Language: Английский

Citations

173
Making Sense of Rodent Models of Anhedonia DOI Creative Commons
Simona Scheggi, Maria Graziella De Montis, Carla Gambarana

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2018, Volume and Issue: 21(11), P. 1049 - 1065

Published: Sept. 19, 2018

A markedly reduced interest or pleasure in activities previously considered pleasurable is a main symptom mood disorder and psychosis often present other psychiatric disorders neurodegenerative diseases. This condition can be labeled as "anhedonia," although its most rigorous connotation the term refers to lost capacity feel that one aspect of complex phenomenon processing responding reward. The responses rewarding stimuli are relatively easy study rodents, experimental conditions consistently persistently impair these used model anhedonia. To this end, long-term exposure environmental aversive primarily used, resulting deficits reward accompanied by mainly reminiscent clinical depressive symptoms. different components impaired induced events assessed tests protocols require degrees time allocation, technical resources, equipment. Rodent models anhedonia valuable tools neurobiological mechanisms underpinning behavioral screening characterization drugs may reverse deficits. In particular, antianhedonic promotivational effects relevant features spectrum psychosis. Thus, more than model, it choice crucial since influences which facets will detected should tuned purpose study.

Language: Английский

Citations

170
A Model for Basic Emotions Using Observations of Behavior in Drosophila DOI Creative Commons
Simeng Gu, Fushun Wang, Nitesh P. Patel

et al.

Frontiers in Psychology, Journal Year: 2019, Volume and Issue: 10

Published: April 24, 2019

Emotion plays a crucial role, both in general human experience and psychiatric illnesses. Despite the importance of emotion, relative lack objective methodologies to scientifically studying emotional phenomena limits our current understanding thereby calls for development novel methodologies, such us study illustrative animal models. Analysis Drosophila other insects has unlocked new opportunities elucidate behavioral phenotypes fundamentally phenomena. Here we propose an integrative model basic emotions based on observations this model. The are internal states that modulated by neuromodulators, these externally expressed as certain stereotypical behaviors, instinct, which is proposed ancient mechanisms survival. There four kinds emotions: happiness, sadness, fear anger, differentially associated with three core affects: reward (happiness), punishment (sadness), stress (fear anger). These affects analogous primary colors (red, yellow, blue) they combined various proportions result more complex "higher order" emotions, love aesthetic emotion. We refer called "Three Primary Color Model Basic Emotions".

Language: Английский

Citations

169
Understanding stress: Insights from rodent models DOI Creative Commons
Fatin Atrooz, Karim A. Alkadhi,

Samina Salim

et al.

Current Research in Neurobiology, Journal Year: 2021, Volume and Issue: 2, P. 100013 - 100013

Published: Jan. 1, 2021

Through incorporating both physical and psychological forms of stressors, a variety rodent models have provided important insights into the understanding stress physiology. Rodent also significant information with regards to mechanistic basis pathophysiology stress-related disorders such as anxiety disorders, depressive illnesses, cognitive impairment post-traumatic disorder. Additionally, served valuable tools in area drug screening development for treatment stress-induced conditions. Although do not accurately reproduce biochemical or physiological parameters response cannot fully mimic natural progression human yet, animal research has answers many scientific questions. In this review article, studies utilizing are described terms their design apparatus, specific focus on capabilities generate reliable behavioral read-out. The focusses utility by discussing examples literature that offer physiologically relevant highlights advancing mission inquiry.

Language: Английский

Citations

109
The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels DOI
Chong Chen, Shin Nakagawa, Yan An

et al.

Frontiers in Neuroendocrinology, Journal Year: 2016, Volume and Issue: 44, P. 83 - 102

Published: Dec. 10, 2016

Language: Английский

Citations

163
Posttraumatic stress disorder: A metabolic disorder in disguise? DOI
Vasiliki Michopoulos,

Aimée Vester,

Gretchen N. Neigh

et al.

Experimental Neurology, Journal Year: 2016, Volume and Issue: 284, P. 220 - 229

Published: May 29, 2016

Language: Английский

Citations

131