Early childhood stress is associated with blunted development of ventral tegmental area functional connectivity DOI Creative Commons
Anne T. Park, Ursula A. Tooley, Julia A. Leonard

et al.

Developmental Cognitive Neuroscience, Journal Year: 2020, Volume and Issue: 47, P. 100909 - 100909

Published: Dec. 25, 2020

Early life stress increases risk for later psychopathology, due in part to changes dopaminergic brain systems that support reward processing and motivation. Work animals has shown early a profound impact on the ventral tegmental area (VTA), which provides dopamine regions including nucleus accumbens (NAcc), anterior hippocampus, medial prefrontal cortex (mPFC), with cascading effects over course of development. However, little is known about how exposure shifts developmental trajectory mesocorticolimbic circuitry humans. In current study, 88 four- nine-year-old children participated resting-state fMRI. Parents completed questionnaires their children's chronic exposure, socioeconomic status (SES) adverse childhood experiences (ACEs). We found an age x SES interaction VTA connectivity, such from higher backgrounds showed positive relationship between VTA-mPFC connectivity. Similarly, we ACEs no Our findings suggest relates blunted maturation connectivity young children, may lead disrupted beyond.

Language: Английский

Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown DOI Creative Commons
Sélim Benjamin Guessoum, Jonathan Lachal, Rahmeth Radjack

et al.

Psychiatry Research, Journal Year: 2020, Volume and Issue: 291, P. 113264 - 113264

Published: June 29, 2020

Language: Английский

Citations

983
Adolescence as a neurobiological critical period for the development of higher-order cognition DOI
Bart Larsen, Beatríz Luna

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 94, P. 179 - 195

Published: Sept. 7, 2018

Language: Английский

Citations

605
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context DOI Creative Commons

Daniel Römer,

Valerie F. Reyna, Theodore D. Satterthwaite

et al.

Developmental Cognitive Neuroscience, Journal Year: 2017, Volume and Issue: 27, P. 19 - 34

Published: July 26, 2017

Recent neuroscience models of adolescent brain development attribute the morbidity and mortality this period to structural functional imbalances between more fully developed limbic regions that subserve reward emotion as opposed those enable cognitive control. We challenge interpretation by distinguishing risk-taking peaks during adolescence (sensation seeking impulsive action) from risk taking declines monotonically childhood adulthood (impulsive choice other decisions under known risk). Sensation is primarily motivated exploration environment ambiguous contexts, while action, which likely be maladaptive, characteristic a subset youth with weak control over motivation. Risk occurs conditions risks reflects increases in executive function well aversion based on gist-based reasoning. propose an alternative Life-span Wisdom Model highlights importance experience gained through adolescence. propose, therefore, recognize adaptive roles cognition play provide complete helpful picture development.

Language: Английский

Citations

344
Aperiodic EEG and 7T MRSI evidence for maturation of E/I balance supporting the development of working memory through adolescence DOI Creative Commons
Shane D. McKeon,

Maria I. Perica,

Ashley C. Parr

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 66, P. 101373 - 101373

Published: April 1, 2024

Adolescence has been hypothesized to be a critical period for the development of human association cortex and higher-order cognition. A defining feature is shift in excitation: inhibition (E/I) balance neural circuitry, however how changes E/I may enhance cortical circuit function support maturational improvements cognitive capacities not known. Harnessing ultra-high field 7 T MR spectroscopy EEG large, longitudinal cohort youth (N = 164, ages 10–32 years old, 347 neuroimaging sessions), we delineate biologically specific associations between age-related excitatory glutamate inhibitory GABA neurotransmitters EEG-derived measures aperiodic activity reflective prefrontal cortex. Specifically, find that developmental increases reflected glutamate:GABA are linked assessed by suppression activity, which turn facilitates robust working memory. These findings indicate role E/I-engendered signaling mechanisms maturation maintenance. More broadly, this multi-modal imaging study provides evidence undergoes physiological consistent with plasticity during adolescence.

Language: Английский

Citations

23
Goal-directed learning in adolescence: neurocognitive development and contextual influences DOI
Linda Wilbrecht, Juliet Y. Davidow

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 176 - 194

Published: Jan. 23, 2024

Language: Английский

Citations

17
A systematic review of neuropsychological studies involving young binge drinkers DOI
Carina Carbia, Eduardo López‐Caneda, Montserrat Corral

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 90, P. 332 - 349

Published: April 18, 2018

Language: Английский

Citations

151
Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators DOI Creative Commons
Cara M. Hueston, John F. Cryan, Yvonne M. Nolan

et al.

Translational Psychiatry, Journal Year: 2017, Volume and Issue: 7(4), P. e1081 - e1081

Published: April 4, 2017

Abstract Adolescence is a critical period for brain maturation. Deciphering how disturbances to the central nervous system at this time affect structure, function and behavioural outputs important better understand any long-lasting effects. Hippocampal neurogenesis occurs during development continues throughout life. In adulthood, integration of these new cells into hippocampus emotional behaviour, cognitive neural plasticity. During adolescent period, maturation heightened levels hippocampal are observed, making alterations particularly consequential. As stress negatively affects neurogenesis, adolescence stressful life, it investigate impact stressor exposure on function. may represent not only which can have effects, but also interventions, such as exercise diet, could ameliorate stress-induced changes addition, intervention promote life-long that would aid in fostering increased This review addresses both acute long-term cognition well response pubertal hormones result differential effects than observed adulthood. We hypothesise an optimal healthy lifestyle positive protect against deficits. conclude future research mechanisms underlying susceptibility stress, diet consequent effect provide insight why be vital correct conditioning

Language: Английский

Citations

148
The relationship between pubertal hormones and brain plasticity: Implications for cognitive training in adolescence DOI Creative Commons
Corinna Laube, Wouter van den Bos, Yana Fandakova

et al.

Developmental Cognitive Neuroscience, Journal Year: 2020, Volume and Issue: 42, P. 100753 - 100753

Published: Jan. 22, 2020

Adolescence may mark a sensitive period for the development of higher-order cognition through enhanced plasticity cortical circuits. At same time, animal research indicates that pubertal hormones represent one key mechanism closing periods in associative neocortex, thereby resulting decreased circuits adolescence. In present review, we set out to solve some existing ambiguity and examine how hormonal changes associated with onset modulate during We build on age-comparative cognitive training studies explore potential change neural resources behavioral repertoire differs across age groups. review human brain imaging studies, which demonstrate link between development, neurochemical mechanisms plasticity, hormones. Overall, existent literature play pivotal role regulating experience-dependent However, extent increase or decrease depend specific domain, sex, networks. discuss implications future suggest systematical longitudinal assessments together interventions be fruitful way toward better understanding adolescent plasticity. As is decreasing developed societies, this also have important educational clinical implications, especially respect effects earlier puberty has learning.

Language: Английский

Citations

128
Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis DOI Open Access
Maria Jalbrzikowski, Rebecca A. Hayes, Stephen J. Wood

et al.

JAMA Psychiatry, Journal Year: 2021, Volume and Issue: 78(7), P. 753 - 753

Published: May 6, 2021

Importance

The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims discover robust neurobiological markers risk.

Objective

To investigate baseline structural differences between and healthy controls as well participants who later developed a psychotic disorder (CHR-PS+) those did not (CHR-PS−).

Design, Setting, Participants

In this case-control study, T1-weighted magnetic resonance imaging (MRI) data were from 31 international sites participating in Clinical High Risk Psychosis Working Group. status was assessed using Comprehensive Assessment At-Risk Mental States or Structured Interview Prodromal Syndromes. MRI scans processed harmonized protocols analyzed within mega-analysis meta-analysis framework January October 2020.

Main Outcomes Measures

Measures regional cortical thickness (CT), surface area, subcortical volumes extracted scans. Independent variables group (CHR vs control group) conversion (CHR-PS+ CHR-PS− group).

Results

Of 3169 included participants, 1428 (45.1%) female, mean (SD; range) age 21.1 (4.9; 9.5-39.9) years. This study 1792 1377 controls. Using longitudinal information, 253 CHR-PS+ group, 1234 305 without follow-up identified. Compared with controls, exhibited widespread lower CT measures (mean [range] Cohend = −0.13 [−0.17 −0.09]), but area volume. Lower fusiform, superior temporal, paracentral regions associated −0.22; 95% CI, −0.35 0.10). Among compared showed stronger negative association left fusiform (F 9.8;P < .001;q .001) 5.9;P .005;q .02). Effect sizes representing resembled patterns observed studies schizophrenia (ρ 0.35; 0.12 0.55;P .004) 22q11.2 microdeletion syndrome diagnosis 0.43; 0.20 0.61;P .001).

Conclusions Relevance

provides evidence subtle, CHR. pattern measure similar reported other large-scale investigations psychosis. Additionally, subset these displayed abnormal associations. Widespread disruptions coupled associations may point postnatal brain developmental processes.

Language: Английский

Citations

105
Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD DOI Creative Commons
Katya Rubia, Marion Criaud,

Melanie Wulff

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 188, P. 43 - 58

Published: Dec. 1, 2018

Attention Deficit Hyperactivity Disorder (ADHD) is associated with poor self-control, underpinned by inferior fronto-striatal deficits. We showed previously that 18 ADHD adolescents over 11 runs of 8.5 min real-time functional magnetic resonance neurofeedback the right frontal cortex (rIFC) progressively increased activation in 2 regions rIFC which was clinical symptom improvement. In this study, we used connectivity analyses to investigate whether fMRI-Neurofeedback resulted dynamic changes underlying neural networks. Whole-brain seed-based were conducted using two clusters showing as seed test for before and after runs. Furthermore, tested resulting improvements they specific when compared a control group who had self-regulate another region. positive relative dorsal caudate anterior cingulate negative default mode network (DMN) such posterior precuneus. correlated correlation findings rIFC-Neurofeedback group. The show first time typically dysfunctional region leads strengthening within fronto-cingulo-striatal networks weakening DMN may be

Language: Английский

Citations

104