Low-dimensional controllability of brain networks DOI Creative Commons

Remy Ben Messaoud,

Vincent Le Du,

Camile Bousfiha

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(1), P. e1012691 - e1012691

Published: Jan. 7, 2025

Identifying the driver nodes of a network has crucial implications in biological systems from unveiling causal interactions to informing effective intervention strategies. Despite recent advances control theory, results remain inaccurate as number drivers becomes too small compared size, thus limiting concrete usability many real-life applications. To overcome this issue, we introduced framework that integrates principles spectral graph theory and output controllability project state into smaller topological space formed by Laplacian structure. Through extensive simulations on synthetic real networks, showed relatively low projected components can significantly improve accuracy. By introducing new low-dimensional metric experimentally validated our method N = 6134 human connectomes obtained UK-biobank cohort. Results revealed previously unappreciated influential brain regions, enabled draw directed maps between differently specialized cerebral systems, yielded insights hemispheric lateralization. Taken together, offered theoretically grounded solution deal with provided brain.

Language: Английский

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease DOI Creative Commons
Nicolai Franzmeier, Emrah Düzel, Frank Jessen

et al.

Brain, Journal Year: 2018, Volume and Issue: 141(4), P. 1186 - 1200

Published: Jan. 6, 2018

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities the presence of brain pathology. A major open question is which mechanisms may support higher reserve capacity, i.e. relatively high performance at a given level Higher functional MRI-assessed connectivity hub left frontal cortex core candidate mechanism underlying as it associated education (i.e. protective factor often reserve) and attenuated impairment prodromal disease. However, no study has yet assessed whether such supports throughout evolution pathological changes disease, including presymptomatic stage when decline subtle. To address this research gap, we obtained cross-sectional resting state MRI 74 participants autosomal dominant 55 controls from Dominantly Inherited Network 75 amyloid-positive elderly participants, well 41 amyloid-negative cognitively normal subjects German Center Neurodegenerative Diseases multicentre on biomarkers sporadic For each participant, global was computed average between (seed) voxel grey matter. As marker stage, applied estimated years symptom onset dominantly inherited cerebrospinal fluid tau levels cases. In both patients, were correlated greater education. significant × interaction found, indicating slower memory cognition connectivity. Similarly, subjects, effect Polynomial regression analysis showed that trajectory shifted towards later patients Together, our findings suggest resilience against development early stages least partially attributable cortex-hub

Language: Английский

Citations

99
Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease DOI Open Access
Michael Ewers, Ying Luan, Lukas Frontzkowski

et al.

Brain, Journal Year: 2021, Volume and Issue: 144(7), P. 2176 - 2185

Published: March 12, 2021

Abstract Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s disease, but the functional brain mechanisms that support remain elusive. Given previous findings normal ageing, we tested hypothesis higher segregation brain’s connectome into distinct networks represents a mechanism underlying disease. Using resting-state MRI, assessed both MRI global system segregation, i.e. balance between-network to within-network connectivity, and alternate index modularity Q as predictors resilience. We performed all analyses two independent samples for validation: (i) 108 individuals with autosomal dominantly inherited disease 71 non-carrier controls; (ii) 156 amyloid-PET-positive subjects across spectrum sporadic 184 amyloid-negative controls. In dominant sample, severity was by estimated years from symptom onset. stage temporal lobe tau-PET (i.e. composite Braak I III regions). samples, whether effect on cognition attenuated at levels network segregation. For found MRI-assessed be associated onset (P = 0.007). Similarly, patients less decrement 0.001) episodic memory 0.004) per unit increase tau-PET. Confirmatory using revealed consistent results. conclusion, connections large-scale supports

Language: Английский

Citations

99
The Contribution of Physical Exercise to Brain Resilience DOI Creative Commons
Ricardo Mário Arida, Lavínia Teixeira-Machado

Frontiers in Behavioral Neuroscience, Journal Year: 2021, Volume and Issue: 14

Published: Jan. 20, 2021

Increasing attention has been given to understanding resilience brain diseases, often described as or cognitive reserve. Among the protective factors for development of resilience, physical activity/exercise considered play an important role. Exercise is known induce many positive effects on brain. As such, exercise represents tool influence neurodevelopment and shape adult react life's challenges. beneficial effects, intervention associated with improvement stress in humans animal models. Thus, a growing number studies have demonstrated that not only recovers minimizes deficits by inducing better neuroplasticity reserve but also counteracts pathology. This evidenced before disease onset after it established. In this review, we aimed present encouraging data from current clinical pre-clinical neuroscience research discuss possible biological mechanisms underlying resilience. We consider implication aging some neurological diseases. Overall, literature indicates brain/cognitive built up regular several stages life, prepares be more resilient impairment consequently

Language: Английский

Citations

93
The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics DOI Creative Commons
Menno M. Schoonheim, Tommy A.A. Broeders, Jeroen Geurts

et al.

NeuroImage Clinical, Journal Year: 2022, Volume and Issue: 35, P. 103108 - 103108

Published: Jan. 1, 2022

Multiple sclerosis is a neuroinflammatory and neurodegenerative disorder of the central nervous system that can be considered network disorder. In MS, lesional pathology continuously disconnects structural pathways in brain, forming disconnection syndrome. Complex functional changes then occur are poorly understood but closely follow clinical status. Studying these has been remains crucial to further decipher complex symptoms like cognitive impairment physical disability. Recent insights especially implicate importance monitoring hubs thalamus default-mode which seem hit hard. Such MS have led hypothesis as continues become disconnected dysfunctional, exceeding certain threshold efficiency loss leads "network collapse". After this collapse, rigid overloaded, at same time faster neurodegeneration accelerated (and cognitive) progression seen. As neuroscience evolved, field now move towards clearer classification collapse itself specific milestone events leading up it. an updated network-focused conceptual framework could directly impact decision making well design network-tailored rehabilitation strategies. This review therefore provides overview recent concepts enhanced our understanding focusing on cognition, new will likely forward near future.

Language: Английский

Citations

64
Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing DOI Creative Commons
Isabella F. Orlando, James M. Shine, Trevor W. Robbins

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 149, P. 105167 - 105167

Published: April 11, 2023

Noradrenergic and cholinergic systems are among the most vulnerable brain in neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's Lewy body dementia, progressive supranuclear palsy. As these fail, they contribute directly to many characteristic cognitive psychiatric symptoms. However, their contribution symptoms is not sufficiently understood, pharmacological interventions targeting noradrenergic have met with mixed success. Part challenge complex neurobiology systems, operating across multiple timescales, non-linear changes adult lifespan disease course. We address challenges a detailed review outlining roles cognition behaviour, how influence disease. By bridging levels analysis, we highlight opportunities for improving drug therapies pursuing personalised medicine strategies.

Language: Английский

Citations

33
Reduced emergent character of neural dynamics in patients with a disrupted connectome DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119926 - 119926

Published: Feb. 3, 2023

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification emergence for experimental data, neuroscientists have been unable empirically test this long-standing conjecture. Here we investigate fundamental question by leveraging recently proposed framework known as "Integrated Information Decomposition," which establishes principled information-theoretic approach operationalise quantify in dynamical systems - including human brain. By analysing functional MRI our results show that emergent hierarchical character dynamics is significantly diminished chronically unresponsive patients suffering severe injury. At level, demonstrate capacity positively correlated with extent organisation activity. Furthermore, combining computational approaches network control theory whole-brain biophysical modelling, reduced severely brain-injured can be mechanistically explained disruptions patients' structural connectome. Overall, suggest chronic unresponsiveness resulting injury may related impairment infrastructures required support emergence.

Language: Английский

Citations

25
Cognition and Cognitive Reserve DOI
Anisha Savarimuthu, R. Joseph Ponniah

Integrative Psychological and Behavioral Science, Journal Year: 2024, Volume and Issue: 58(2), P. 483 - 501

Published: Jan. 27, 2024

Language: Английский

Citations

14
Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies DOI Creative Commons
Andrea I. Luppi, S. Parker Singleton, Justine Y. Hansen

et al.

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(9), P. 1142 - 1161

Published: Aug. 5, 2024

Abstract The mechanisms linking the brain’s network structure to cognitively relevant activation patterns remain largely unknown. Here, by leveraging principles of control, we show how architecture human connectome shapes transitions between 123 experimentally defined cognitive maps (cognitive topographies) from NeuroSynth meta-analytic database. Specifically, systematically integrated large-scale multimodal neuroimaging data functional magnetic resonance imaging, diffusion tractography, cortical morphometry and positron emission tomography simulate anatomically guided states can be reshaped neurotransmitter engagement or changes in thickness. Our model incorporates neurotransmitter-receptor density (18 receptors transporters) thickness pertaining a wide range mental health, neurodegenerative, psychiatric neurodevelopmental diagnostic categories (17,000 patients 22,000 controls). results provide comprehensive look-up table charting brain organization chemoarchitecture interact manifest different topographies, establish principled foundation for systematic identification ways promote selective topographies.

Language: Английский

Citations

10
The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health DOI Creative Commons

Felipe Rici Azarias,

Gustavo Henrique Doná Rodrigues Almeida, Luana Félix de Melo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 395 - 395

Published: April 10, 2025

The Default Mode Network has been extensively studied in recent decades due to its central role higher cognitive processes and relevance for understanding mental disorders. This neural network, characterized by synchronized coherent activity at rest, is intrinsically linked self-reflection, exploration, social interaction, emotional processing. Our of the DMN extends beyond humans non-human animals, where it observed various species, highlighting evolutionary basis adaptive significance throughout phylogenetic history. Additionally, plays a crucial brain development during childhood adolescence, influencing fundamental processes. literature review aims provide comprehensive overview DMN, addressing structural, functional, aspects, as well impact from infancy adulthood. By gaining deeper organization function we can advance our knowledge mechanisms that underlie cognition, behavior, health. This, turn, lead more effective therapeutic strategies range neuropsychiatric conditions.

Language: Английский

Citations

1
Warnings and caveats in brain controllability DOI
Chengyi Tu, Rodrigo P. Rocha, Maurizio Corbetta

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 176, P. 83 - 91

Published: April 12, 2018

Language: Английский

Citations

77