Translational Psychiatry,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: Nov. 18, 2019
Abstract
Previous
research
indicates
that
anxiety
disorders
are
characterized
by
an
overgeneralization
of
conditioned
fear
as
compared
with
healthy
participants.
Therefore,
generalization
is
considered
a
key
mechanism
for
the
development
disorders.
However,
systematic
investigations
on
variance
in
lacking.
current
study
aims
at
identifying
distinctive
phenotypes
among
To
this
end,
1175
participants
completed
differential
conditioning
phase
followed
test.
identify
patterns
generalization,
we
used
k-means
clustering
algorithm
based
individual
arousal
gradients.
Subsequently,
examined
reliability
and
validity
clusters
phenotypical
differences
between
subgroups
basis
psychometric
data
markers
expression.
Cluster
analysis
reliably
revealed
five
systematically
differed
mean
responses,
differentiation
threat
safety,
linearity
gradients,
though
response
levels
accounted
most
variance.
Remarkably,
responses
were
already
evident
during
acquisition
corresponded
closely
to
measures
traits.
The
identified
described
individuals
distinct
characteristics
Following
dimensional
view
psychopathology,
these
likely
delineate
risk
factors
As
crucial
group
acquisition,
our
results
emphasize
importance
average
safety
Biological Psychiatry Global Open Science,
Journal Year:
2021,
Volume and Issue:
1(3), P. 171 - 179
Published: June 5, 2021
Intolerance
of
uncertainty
(IU),
the
tendency
to
find
distressing,
is
an
important
transdiagnostic
dimension
in
mental
health
disorders.
Higher
self-reported
IU
has
been
linked
poorer
threat
extinction
training
(i.e.,
updating
safe
associations),
a
key
process
that
targeted
exposure-based
therapies.
However,
it
remains
be
seen
whether
IU-related
effects
during
are
reliably
and
specifically
driven
by
construct
or
particular
subcomponent
over
other
measures
anxiety.
A
meta-analysis
studies
from
different
laboratories
(18
experiments;
sample
N
=
1006)
was
conducted
on
associations
between
variants
27-item,
12-item,
inhibitory,
prospective
subscales),
trait
anxiety,
via
skin
conductance
response.
The
specificity
assessed
against
All
IU,
but
not
were
associated
with
response
continued
responding
old
cue).
Specificity
observed
for
majority
findings
suggest
broadly
accounts
difficulties
specific
These
demonstrate
robustness
highlight
potential
opportunities
translational
work
target
therapies
rely
principles
such
as
exposure
therapy.
Annual Review of Clinical Psychology,
Journal Year:
2022,
Volume and Issue:
18(1), P. 233 - 258
Published: Feb. 8, 2022
The
authors
describe
how
contemporary
learning
theory
and
research
provide
the
basis
for
models
of
etiology
maintenance
anxiety
related
disorders.
They
argue
that
accounts
much
complexity
associated
with
individual
differences
in
development
course
these
These
insights
from
modern
on
overcome
limitations
earlier
behavioral
approaches,
which
were
overly
simplistic
have
been
justifiably
criticized.
show
considerations
early
histories
temperamental
vulnerabilities
affect
short-
long-term
likelihood
experiences
stressful
events
will
lead
to
also
discuss
contextual
variables
during
after
influence
disorder
symptoms.
Thus,
a
rich
nuanced
understanding
Translational Psychiatry,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: Nov. 18, 2019
Abstract
Previous
research
indicates
that
anxiety
disorders
are
characterized
by
an
overgeneralization
of
conditioned
fear
as
compared
with
healthy
participants.
Therefore,
generalization
is
considered
a
key
mechanism
for
the
development
disorders.
However,
systematic
investigations
on
variance
in
lacking.
current
study
aims
at
identifying
distinctive
phenotypes
among
To
this
end,
1175
participants
completed
differential
conditioning
phase
followed
test.
identify
patterns
generalization,
we
used
k-means
clustering
algorithm
based
individual
arousal
gradients.
Subsequently,
examined
reliability
and
validity
clusters
phenotypical
differences
between
subgroups
basis
psychometric
data
markers
expression.
Cluster
analysis
reliably
revealed
five
systematically
differed
mean
responses,
differentiation
threat
safety,
linearity
gradients,
though
response
levels
accounted
most
variance.
Remarkably,
responses
were
already
evident
during
acquisition
corresponded
closely
to
measures
traits.
The
identified
described
individuals
distinct
characteristics
Following
dimensional
view
psychopathology,
these
likely
delineate
risk
factors
As
crucial
group
acquisition,
our
results
emphasize
importance
average
safety
