An Active Inference Approach to Interoceptive Psychopathology

Annual Review of Clinical Psychology, Journal Year: 2019, Volume and Issue: 15(1), P. 97 - 122

Published: May 7, 2019

Interoception refers to the process by which nervous system senses and integrates signals originating from within body, providing a momentary mapping of body's internal landscape its relationship outside world. Active inference is based on premise that afferent sensory input brain constantly shaped modified prior expectations. In this review we propose interoceptive psychopathology results two primary dysfunctions: First, individuals have abnormally strong expectations situations elicit bodily change (i.e., hyperprecise priors), second, they great difficulty adjusting these when environment changes context rigidity). Here discuss how dysfunctions potentially manifest in mental illness interventions aimed at altering processing can help create more realistic model state.

Language: Английский

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Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2019, Volume and Issue: 90(6), P. 642 - 651

Published: Jan. 25, 2019

Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact on patients’ quality life. Currently, treatment proceeds by trial and error limited success, probably due to presence different underlying mechanisms. Recent neuroscientific advances offer potential develop tools for differentiating these mechanisms individual patients ultimately provide principled basis selection. However, development differential diagnosis will require guidance pathophysiological cognitive theories that propose which can be assessed patients. This article provides an overview contemporary fatigue MS discusses how they may become measurable emerging technologies thus lay foundation future personalised treatments.

Language: Английский

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Fatigue, Sleep, and Autoimmune and Related Disorders

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 6, 2019

Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac chronic syndrome, rheumatoid arthritis. Fatigue multi-faceted broadly defined, which makes understanding cause of its manifestations especially difficult in conditions diverse pathology including diseases. In general, defined by periods exhaustion that interfere normal activities. The severity duration episodes vary, but can difficulty for even simple tasks like climbing stairs or crossing room. exact mechanisms are not well understood, perhaps due to broad definition. Nevertheless, physiological processes known play a role include oxygen/nutrient supply, metabolism, mood, motivation, sleepiness—all affected inflammation. Additionally, an important contributing element central nervous system—a region impacted either directly indirectly numerous related disorders. This review describes how inflammation system contribute suggests potential involved likely exhibited

Language: Английский

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The acute exercise-cognition interaction: From the catecholamines hypothesis to an interoception model

International Journal of Psychophysiology, Journal Year: 2021, Volume and Issue: 170, P. 75 - 88

Published: Oct. 18, 2021

Language: Английский

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Physical activity and interoceptive processing: Theoretical considerations for future research

International Journal of Psychophysiology, Journal Year: 2021, Volume and Issue: 166, P. 38 - 49

Published: May 7, 2021

Interoception, defined as the sense of internal bodily state, plays a critical role in physical, cognitive, emotional and social well-being. Regarding physical well-being, contemporary models exercise regulation incorporate interoceptive processes exertion. Top-down continuously monitor physiological condition body to ensure allostasis is maintained, however, flagged perturbations also appear influence these higher order return. More specifically, enhancing one's arousal by means activity viable way manipulating afferent input entering system, appearing optimise integration early sensory stimulation with later affective responses. Despite this, relationship between top-down underrepresented research. We here address this gap integrating findings from different disciplines support overlapping mechanisms, hope stimulating further research field. Developing our understanding how are shaped could hold significant clinical implications considering impact deficits mental health

Language: Английский

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Functional significance of the dorsolateral prefrontal cortex during exhaustive exercise

Biological Psychology, Journal Year: 2022, Volume and Issue: 175, P. 108442 - 108442

Published: Oct. 13, 2022

Language: Английский

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Computational mechanisms underlying the dynamics of physical and cognitive fatigue

Cognition, Journal Year: 2023, Volume and Issue: 240, P. 105603 - 105603

Published: Aug. 28, 2023

The willingness to exert effort for reward is essential but comes at the cost of fatigue. Theories suggest fatigue increases after both physical and cognitive exertion, subsequently reducing motivation effort. Yet a mechanistic understanding how this happens on moment-to-moment basis, whether mechanisms are common mental effort, lacking. In two studies, participants reported momentary (trial-by-trial) ratings during an effort-based decision-making task requiring either (grip-force) or (mental arithmetic) Using novel computational model, we show that fluctuates from trial-to-trial as function exerted predicts subsequent choices. This mechanism was shared across domains. Selective domain, committing errors also induced in feelings These findings provide insight into computations underlying influence effortful exertion motivation,

Language: Английский

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Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Dec. 14, 2020

Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear be cognitive and potentially comprise "fatigue network". These include the striatum basal ganglia, dorsolateral prefrontal cortex (DLPFC), dorsal anterior cingulate (dACC), ventro-medial (vmPFC) insula. However, no been conducted assess whether connectivity between these changes as function fatigue. We used task-based paradigm induce in 39 healthy individuals, regressed signal associated with task out data, investigated how changed increased. observed other frontal largely decreased increased while seeds more posterior Furthermore striatum, DLPFC, insula vmPFC appeared central 'nodes' hubs network. findings represent first demonstration areas

Language: Английский

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Cognitive Fatigue Effects on Physical Performance: The Role of Interoception

Sports Medicine, Journal Year: 2020, Volume and Issue: 50(10), P. 1703 - 1708

Published: July 14, 2020

Language: Английский

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The challenges of chronic pain and fatigue

Clinical Medicine, Journal Year: 2021, Volume and Issue: 21(1), P. 19 - 27

Published: Jan. 1, 2021

ABSTRACT

In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both are common, troubling frequently overlapping symptoms, describe both burden 'clinical problem'. We commonly associated symptoms possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory interoceptive processes, which may inform treatment targets. suggest a multidisciplinary management approach.

Language: Английский

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