Toward the unity of pathological and exertional fatigue: A predictive processing model DOI Creative Commons
Aaron Greenhouse‐Tucknott, Jake Butterworth, James G. Wrightson

et al.

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2021, Volume and Issue: 22(2), P. 215 - 228

Published: Oct. 19, 2021

Abstract Fatigue is a common experience in both health and disease. Yet, pathological (i.e., prolonged or chronic) transient exertional) fatigue symptoms are traditionally considered distinct, compounding separation between interested research fields within the study of fatigue. Within clinical neurosciences, nascent frameworks position as product inference derived through hierarchical predictive processing. The metacognitive theory dyshomeostasis (Stephan et al., 2016) states that emerges from mechanism which detection persistent mismatches prior interoceptive predictions ascending sensory evidence prediction error) signals low for internal generative models, undermine an agent’s feeling mastery over body thus experienced phenomenologically Although acute, subjective exertional have also been associated with increasing error, dynamic computations underlie its development not clearly defined. Here, drawing on dyshomeostasis, we extend this account to offer explicit description during extended periods (physical) exertion. Accordingly, it proposed loss certainty confidence control response error features foundation conscious nonpathological

Language: Английский

An Active Inference Approach to Interoceptive Psychopathology DOI Open Access
Martin P. Paulus, Justin S. Feinstein, Sahib S. Khalsa

et al.

Annual Review of Clinical Psychology, Journal Year: 2019, Volume and Issue: 15(1), P. 97 - 122

Published: May 7, 2019

Interoception refers to the process by which nervous system senses and integrates signals originating from within body, providing a momentary mapping of body's internal landscape its relationship outside world. Active inference is based on premise that afferent sensory input brain constantly shaped modified prior expectations. In this review we propose interoceptive psychopathology results two primary dysfunctions: First, individuals have abnormally strong expectations situations elicit bodily change (i.e., hyperprecise priors), second, they great difficulty adjusting these when environment changes context rigidity). Here discuss how dysfunctions potentially manifest in mental illness interventions aimed at altering processing can help create more realistic model state.

Language: Английский

Citations

287
Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis DOI Creative Commons
Zina‐Mary Manjaly, Neil A. Harrison, Hugo Critchley

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2019, Volume and Issue: 90(6), P. 642 - 651

Published: Jan. 25, 2019

Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact on patients’ quality life. Currently, treatment proceeds by trial and error limited success, probably due to presence different underlying mechanisms. Recent neuroscientific advances offer potential develop tools for differentiating these mechanisms individual patients ultimately provide principled basis selection. However, development differential diagnosis will require guidance pathophysiological cognitive theories that propose which can be assessed patients. This article provides an overview contemporary fatigue MS discusses how they may become measurable emerging technologies thus lay foundation future personalised treatments.

Language: Английский

Citations

262
Fatigue, Sleep, and Autoimmune and Related Disorders DOI Creative Commons

Mark R. Zielinski,

David M. Systrom,

Noel R. Rose

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 6, 2019

Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac chronic syndrome, rheumatoid arthritis. Fatigue multi-faceted broadly defined, which makes understanding cause of its manifestations especially difficult in conditions diverse pathology including diseases. In general, defined by periods exhaustion that interfere normal activities. The severity duration episodes vary, but can difficulty for even simple tasks like climbing stairs or crossing room. exact mechanisms are not well understood, perhaps due to broad definition. Nevertheless, physiological processes known play a role include oxygen/nutrient supply, metabolism, mood, motivation, sleepiness—all affected inflammation. Additionally, an important contributing element central nervous system—a region impacted either directly indirectly numerous related disorders. This review describes how inflammation system contribute suggests potential involved likely exhibited

Language: Английский

Citations

189
The acute exercise-cognition interaction: From the catecholamines hypothesis to an interoception model DOI
Terry McMorris

International Journal of Psychophysiology, Journal Year: 2021, Volume and Issue: 170, P. 75 - 88

Published: Oct. 18, 2021

Language: Английский

Citations

69
Physical activity and interoceptive processing: Theoretical considerations for future research DOI Creative Commons
Amie Wallman-Jones, Pandelis Perakakis, Manos Tsakiris

et al.

International Journal of Psychophysiology, Journal Year: 2021, Volume and Issue: 166, P. 38 - 49

Published: May 7, 2021

Interoception, defined as the sense of internal bodily state, plays a critical role in physical, cognitive, emotional and social well-being. Regarding physical well-being, contemporary models exercise regulation incorporate interoceptive processes exertion. Top-down continuously monitor physiological condition body to ensure allostasis is maintained, however, flagged perturbations also appear influence these higher order return. More specifically, enhancing one's arousal by means activity viable way manipulating afferent input entering system, appearing optimise integration early sensory stimulation with later affective responses. Despite this, relationship between top-down underrepresented research. We here address this gap integrating findings from different disciplines support overlapping mechanisms, hope stimulating further research field. Developing our understanding how are shaped could hold significant clinical implications considering impact deficits mental health

Language: Английский

Citations

59
The effect of physical fatigue on the performance of soccer players: A systematic review DOI Creative Commons
Felipe Dambroz, Filipe Manuel Clemente, Israel Teoldo

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(7), P. e0270099 - e0270099

Published: July 14, 2022

This study aimed to carry out a systematic review analyze, describe and discuss the effect of physical fatigue on performance soccer players. For this review, searches were performed in Pubmed, Web Science SPORTDiscus electronic database until October 3, 2020, following guidelines PRISMA. A total 12 articles met inclusion criteria: i) healthy players from any age group, competitive level or sex; ii) exposure fatigue; iii) pre post-physical conditions; iv) players' cognitive, technical, tactical performances v) no restrictions regarding design. The results section was organized four main dimensions: tactical. Studies cognitive have shown divergent results, varying according task employed protocol used. Regarding technical performance, negative effects found fundamentals pass, dribble kick. With regard studies reduction sprint capacity distances covered at high velocity. Finally, only that analyzed field showed an increase team's collective behavior, but did not include analysis individual actions. In summary, show is inconclusive are negatively affected. there lack information topic current literature.

Language: Английский

Citations

39
Functional significance of the dorsolateral prefrontal cortex during exhaustive exercise DOI
Marcelo Bigliassi, Edson Filho

Biological Psychology, Journal Year: 2022, Volume and Issue: 175, P. 108442 - 108442

Published: Oct. 13, 2022

Language: Английский

Citations

39
Computational mechanisms underlying the dynamics of physical and cognitive fatigue DOI Creative Commons
Julian Matthews, M. Andrea Pisauro, Mindaugas Jurgelis

et al.

Cognition, Journal Year: 2023, Volume and Issue: 240, P. 105603 - 105603

Published: Aug. 28, 2023

The willingness to exert effort for reward is essential but comes at the cost of fatigue. Theories suggest fatigue increases after both physical and cognitive exertion, subsequently reducing motivation effort. Yet a mechanistic understanding how this happens on moment-to-moment basis, whether mechanisms are common mental effort, lacking. In two studies, participants reported momentary (trial-by-trial) ratings during an effort-based decision-making task requiring either (grip-force) or (mental arithmetic) Using novel computational model, we show that fluctuates from trial-to-trial as function exerted predicts subsequent choices. This mechanism was shared across domains. Selective domain, committing errors also induced in feelings These findings provide insight into computations underlying influence effortful exertion motivation,

Language: Английский

Citations

27
Modulation of beta oscillatory dynamics in motor and frontal areas during physical fatigue DOI Creative Commons
Pierre‐Marie Matta, Robin Baurès, Julien Duclay

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 30, 2025

Beta-band oscillations have been suggested to promote the maintenance of current motor (or cognitive) set, thus signaling 'status quo' system. While this hypothesis has reliably demonstrated in many studies, it fails explain changes beta-band activity due accumulation physical fatigue. In study, we aimed reconcile functional role beta during fatigue within status quo theory. Using an innovative electroencephalography design, identified two distinct power dynamics areas as rises: (i) enhancement at rest, supposedly promoting resting state, and (ii) a decrease contraction, thought reflect increase cortex activation necessary cope with muscular We then conducted effective connectivity analyses, which revealed that modulations contractions were driven by frontal areas. Finally, implemented biologically plausible model replicate characterize our results mechanistically. Together, findings anchor paradigm theory, shedding light on further discuss unified interpretation might conflicting evidence previously encountered literature.

Language: Английский

Citations

1
Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network DOI Creative Commons
Glenn R. Wylie, Bing Yao, Helen M. Genova

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Dec. 14, 2020

Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear be cognitive and potentially comprise "fatigue network". These include the striatum basal ganglia, dorsolateral prefrontal cortex (DLPFC), dorsal anterior cingulate (dACC), ventro-medial (vmPFC) insula. However, no been conducted assess whether connectivity between these changes as function fatigue. We used task-based paradigm induce in 39 healthy individuals, regressed signal associated with task out data, investigated how changed increased. observed other frontal largely decreased increased while seeds more posterior Furthermore striatum, DLPFC, insula vmPFC appeared central 'nodes' hubs network. findings represent first demonstration areas

Language: Английский

Citations

62