Higher-order sensorimotor circuit of the brain's global network supports human consciousness DOI Creative Commons
Pengmin Qin,

Xuehai Wu,

Changwei W. Wu

et al.

NeuroImage, Journal Year: 2021, Volume and Issue: 231, P. 117850 - 117850

Published: Feb. 15, 2021

Consciousness is a mental characteristic of the human mind, whose exact neural features remain unclear. We aimed to identify critical nodes within brain's global functional network that support consciousness. To end, we collected large fMRI resting state dataset with subjects in at least one following three consciousness states: preserved (including healthy awake state, and patients brain injury history (BI) fully conscious), reduced N1-sleep minimally conscious state), lost N3-sleep anesthesia, unresponsive wakefulness state). also included unique rapid eye movement sleep (REM-sleep) test for presence minimum movements sensory input. nodes, i.e., hubs, network, used graph-theoretical measure degree centrality conjoined ROI-based connectivity. Using these methods, identified various higher-order motor regions including supplementary area, bilateral supramarginal gyrus (part inferior parietal lobule), supragenual/dorsal anterior cingulate cortex, left middle temporal gyrus, could be important hubs was significantly when or absent. Additionally, sensorimotor circuit, which connectivity among correlated levels across different groups, remained present REM-sleep group. Taken together, demonstrated forming integration circuit are involved supporting network. That offers novel more mechanism-guided treatment targets disorders

Language: Английский

The brain and its time: intrinsic neural timescales are key for input processing DOI Creative Commons
Mehrshad Golesorkhi, Javier Gómez‐Pilar, Federico Zilio

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Aug. 16, 2021

Abstract We process and integrate multiple timescales into one meaningful whole. Recent evidence suggests that the brain displays a complex multiscale temporal organization. Different regions exhibit different as described by concept of intrinsic neural (INT); however, their function mechanisms remains unclear. review recent literature on INT propose they are key for input processing. Specifically, shared across species, i.e., sharing. This role in encoding inputs through matching inputs’ stochastics with ongoing statistics brain’s activity, encoding. Following simulation empirical data, we point out integration versus segregation sampling deeply grounds within its environmental evolutionary context. It carries major implications understanding mental features psychiatric disorders, well going beyond integrating artificial intelligence.

Language: Английский

Citations

120
The ConTraSt database for analysing and comparing empirical studies of consciousness theories DOI
Itay Yaron, Lucía Melloni, Michael Pitts

et al.

Nature Human Behaviour, Journal Year: 2022, Volume and Issue: 6(4), P. 593 - 604

Published: Feb. 21, 2022

Language: Английский

Citations

84
Temporo-spatial Theory of Consciousness (TTC) – Bridging the gap of neuronal activity and phenomenal states DOI
Georg Northoff, Federico Zilio

Behavioural Brain Research, Journal Year: 2022, Volume and Issue: 424, P. 113788 - 113788

Published: Feb. 8, 2022

Language: Английский

Citations

81
An adversarial collaboration to critically evaluate theories of consciousness DOI Creative Commons
Oscar Ferrante, Urszula Górska, Simon Henin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation 12 256 human subjects viewed suprathreshold stimuli for variable durations while was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

Citations

53
Beyond task response—Pre-stimulus activity modulates contents of consciousness DOI
Georg Northoff, Federico Zilio, Jianfeng Zhang

et al.

Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 19 - 37

Published: March 4, 2024

Language: Английский

Citations

22
Adversarial testing of global neuronal workspace and integrated information theories of consciousness DOI Creative Commons
Oscar Ferrante, Urszula Górska, Simon Henin

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, but not been directly compared3. Here we present an open science adversarial collaboration juxtaposing integrated information theory (IIT)4,5 and global neuronal workspace (GNWT)6-10 via a theory-neutral consortium11-13. The proponents the consortium developed preregistered experimental design, divergent predictions, expected outcomes interpretation thereof12. Human participants (n = 256) viewed suprathreshold stimuli for variable durations while neural activity was measured with functional magnetic resonance imaging, magnetoencephalography intracranial electroencephalography. We found about conscious content in visual, ventrotemporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early visual areas. results align some predictions of IIT GNWT, substantially challenging key tenets both theories. For IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. challenges extend to other consciousness share tested here14-17. Beyond theories, alternative approach advance cognitive neuroscience through principled, theory-driven, collaborative research highlight need quantitative framework systematic testing building.

Language: Английский

Citations

4
Unpacking the Complexities of Consciousness: Theories and Reflections DOI Creative Commons
Liad Mudrik, Mélanie Boly,

Stanislas Dehaene

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106053 - 106053

Published: Feb. 1, 2025

As the field of consciousness science matures, research agenda has expanded from an initial focus on neural correlates consciousness, to developing and testing theories consciousness. Several have been put forward, each aiming elucidate relationship between brain function. However, there is ongoing, intense debate regarding whether these examine same phenomenon. And, despite ongoing efforts, it seems like so far failed converge around any single theory, instead exhibits significant polarization. To advance this discussion, proponents five prominent consciousness-Global Neuronal Workspace Theory (GNWT), Higher-Order Theories (HOT), Integrated Information (IIT), Recurrent Processing (RPT), Predictive (PP)-engaged in a public 2022, as part annual meeting Association for Scientific Study Consciousness (ASSC). They were invited clarify explananda their theories, articulate core mechanisms underpinning corresponding explanations, outline foundational premises. This was followed by open discussion that delved into testability potential evidence could refute them, areas consensus disagreement. Most importantly, demonstrated at stage, more controversy than agreement pertaining most basic questions what is, how identify conscious states, required theory Addressing crucial advancing towards deeper understanding comparison competing theories.

Language: Английский

Citations

3
Temporal hierarchy of intrinsic neural timescales converges with spatial core-periphery organization DOI Creative Commons
Mehrshad Golesorkhi, Javier Gómez‐Pilar, Shankar Tumati

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: March 4, 2021

Abstract The human cortex exhibits intrinsic neural timescales that shape a temporal hierarchy. Whether this hierarchy follows the spatial of its topography, namely core-periphery organization, remains an open issue. Using magnetoencephalography data, we investigate during rest and task states; measure autocorrelation window in short (ACW-50) and, introducing novel variant, long (ACW-0) windows. We demonstrate longer ACW-50 ACW-0 networks located at core compared to those periphery with states showing high ACW correlation. Calculating rest-task differences, i.e., subtracting shared reveals task-specific changes distinct networks. Finally, employing kernel density estimation, machine learning, simulation, better prediction classifying region’s time as or periphery. Overall, our findings provide fundamental insight into how cortex’s converges

Language: Английский

Citations

97
Are intrinsic neural timescales related to sensory processing? Evidence from abnormal behavioral states DOI Creative Commons
Federico Zilio, Javier Gómez‐Pilar, Shumei Cao

et al.

NeuroImage, Journal Year: 2020, Volume and Issue: 226, P. 117579 - 117579

Published: Nov. 20, 2020

The brain exhibits a complex temporal structure which translates into hierarchy of distinct neural timescales. An open question is how these intrinsic timescales are related to sensory or motor information processing and whether dynamics have common patterns in different behavioral states. We address questions by investigating the brain's healthy controls, (amyotrophic lateral sclerosis, locked-in syndrome), (anesthesia, unresponsive wakefulness progressive reduction (from awake states over N1, N2, N3). employed combination measures from EEG resting-state data: auto-correlation window (ACW), power spectral density (PSD), power-law exponent (PLE). Prolonged accompanied shift towards slower frequencies were observed conditions with deficits, but not deficits. Our results establish that spontaneous activity's timescale capacity specifically supports rather than brain.

Language: Английский

Citations

90
Theoretical Models of Consciousness: A Scoping Review DOI Creative Commons
Davide Sattin, Francesca Giulia Magnani,

Laura Bartesaghi

et al.

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(5), P. 535 - 535

Published: April 24, 2021

The amount of knowledge on human consciousness has created a multitude viewpoints and it is difficult to compare synthesize all the recent scientific perspectives. Indeed, there are many definitions multiple approaches study neural correlates (NCC). Therefore, main aim this article collect data various theories published between 2007–2017 them provide general overview topic. To describe each theory, we developed thematic grid called dimensional model, which qualitatively quantitatively analyzes how article, related one specific debates/analyzes issue. Among 1130 articles assessed, 85 full texts were included in prefinal step. Finally, scoping review analyzed 68 that described 29 consciousness. We found heterogeneous perspectives analyzed. Those with highest grade variability as follows: subjectivity, NCC, consciousness/cognitive function. sub-cortical structures, thalamus, basal ganglia, hippocampus most indicated, whereas cingulate, prefrontal, temporal areas reported for cortical ones also including thalamo-cortical system. Moreover, several 21 new sub-classifications.

Language: Английский

Citations

76