As without, so within: how the brain's temporo-spatial alignment to the environment shapes consciousness DOI Creative Commons
Georg Northoff, Philipp Klar, Magnus Bein

et al.

Interface Focus, Journal Year: 2023, Volume and Issue: 13(3)

Published: April 14, 2023

Consciousness is constituted by a structure that includes contents as foreground and the environment background. This structural relation between experiential background presupposes relationship brain environment, often neglected in theories of consciousness. The temporo-spatial theory consciousness addresses brain–environment concept labelled ‘temporo-spatial alignment’. Briefly, alignment refers to brain's neuronal activity's interaction with adaption interoceptive bodily exteroceptive environmental stimuli, including their symmetry key for Combining empirical data, this article attempts demonstrate yet unclear neuro-phenomenal mechanisms alignment. First, we suggest three layers environment. These span across continuum from longer shorter timescales. (i) layer comprises more powerful timescales mediating topographic-dynamic similarities different subjects' brains. (ii) intermediate mixture medium-scaled allowing stochastic matching inputs activity through intrinsic temporal receptive windows. (iii) less entrainment stimuli onset phase shifting resetting. Second, elaborate on how correspond respective phenomenal inter-subjectively shared contextual An mediates A specific fast-changing Overall, may provide mechanism whose modulate corresponding Temporo-spatial can bridging principle linking physical-energetic (free energy), dynamic (symmetry), (three distinct time–space scales) (form featured background–intermediate–foreground)

Language: Английский

Intrinsic neural timescales: temporal integration and segregation DOI
Annemarie Wolff, Nareg Berberian, Mehrshad Golesorkhi

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(2), P. 159 - 173

Published: Jan. 3, 2022

Language: Английский

Citations

162
The brain and its time: intrinsic neural timescales are key for input processing DOI Creative Commons
Mehrshad Golesorkhi, Javier Gómez‐Pilar, Federico Zilio

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Aug. 16, 2021

Abstract We process and integrate multiple timescales into one meaningful whole. Recent evidence suggests that the brain displays a complex multiscale temporal organization. Different regions exhibit different as described by concept of intrinsic neural (INT); however, their function mechanisms remains unclear. review recent literature on INT propose they are key for input processing. Specifically, shared across species, i.e., sharing. This role in encoding inputs through matching inputs’ stochastics with ongoing statistics brain’s activity, encoding. Following simulation empirical data, we point out integration versus segregation sampling deeply grounds within its environmental evolutionary context. It carries major implications understanding mental features psychiatric disorders, well going beyond integrating artificial intelligence.

Language: Английский

Citations

120
Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders DOI Creative Commons
Junichi Yamamoto, Takumi Ito, Yuki Yamaguchi

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6234 - 6250

Published: Jan. 1, 2022

Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. This tutorial review provides an overview of mechanism action thalidomide-based their future perspectives.

Language: Английский

Citations

88
Temporo-spatial Theory of Consciousness (TTC) – Bridging the gap of neuronal activity and phenomenal states DOI
Georg Northoff, Federico Zilio

Behavioural Brain Research, Journal Year: 2022, Volume and Issue: 424, P. 113788 - 113788

Published: Feb. 8, 2022

Language: Английский

Citations

81
Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task DOI Creative Commons
Morten L. Kringelbach, Yonatan Sanz Perl, Enzo Tagliazucchi

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(2)

Published: Jan. 13, 2023

Identifying the functional specialization of brain has moved from using cognitive tasks and resting state to ecological relevant, naturalistic movies. We leveraged a large-scale neuroimaging dataset directly investigate hierarchical reorganization activity when watching films compared performing seven resting. A thermodynamics-inspired whole-brain model paradigm revealed generative underlying mechanisms for changing balance in causal interactions between regions different conditions. Paradoxically, hierarchy is flatter movie-watching, level nonreversibility significantly smaller comparison both rest tasks, where latter turn have highest levels nonreversibility. The were by model-based effective connectivity (GEC). Naturalistic could therefore provide fast convenient way measure important changes GEC (integrating anatomical connectivity) found in, example, neuropsychiatric disorders. Overall, this study demonstrates benefits moving toward more neuroscience.

Language: Английский

Citations

62
Beyond task response—Pre-stimulus activity modulates contents of consciousness DOI
Georg Northoff, Federico Zilio, Jianfeng Zhang

et al.

Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 19 - 37

Published: March 4, 2024

Language: Английский

Citations

22
Is depression a global brain disorder with topographic dynamic reorganization? DOI Creative Commons
Georg Northoff, Dušan Hirjak

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 5, 2024

Abstract Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal mechanisms underlying such co-occurrence remain yet unclear. Rather than linking localizing single to specific regions or networks, this perspective proposes more global dynamic topographic approach. We first review recent findings on brain activity changes during both rest task states in MDD showing reorganization with shift from unimodal transmodal regions. Next, we out two candidate that may underlie mediate abnormal uni-/transmodal topography, namely shifts shorter longer timescales abnormalities the excitation-inhibition balance. Finally, show how relates various their co-occurrence. This amounts what describe as ‘Topographic reorganization’ which extends our earlier ‘Resting state hypothesis depression’ complements other models MDD.

Language: Английский

Citations

17
When makes you unique: Temporality of the human brain fingerprint DOI Creative Commons
Dimitri Van De Ville, Younes Farouj, Maria Giulia Preti

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(42)

Published: Oct. 15, 2021

Patterns of human brain activity emerge from temporally limited fMRI observations, allowing identification individuals.

Language: Английский

Citations

88
Neuroscience and architecture: Modulating behavior through sensorimotor responses to the built environment DOI Creative Commons
Zakaria Djebbara, Ole B. Jensen, Francisco J. Parada

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104715 - 104715

Published: May 30, 2022

As we move through the world, natural and built environments implicitly guide behavior by appealing to certain sensory motor dynamics. This process can be motivated automatic attention environmental features that resonate with specific sensorimotor responses. review aims at providing a psychobiological framework describing how lead automated responses defined neurophysiological mechanisms underlying attention. Through use of processes in subsets cortical structures, goal this is describe on neuronal level functional link between designed environment By distinguishing elaborate employs for adaptation. realized thalamo-cortical network integrating aspects behavior. We highlight transthalamic transmission from an Enactive predictive perspective recent studies effectively modulated systematically manipulating features. end suggesting promising combination neuroimaging computational analysis future studies.

Language: Английский

Citations

43
Ongoing Brain Activity and Its Role in Cognition: Dual versus Baseline Models DOI
Georg Northoff, Deniz Vatansever, Andrea Scalabrini

et al.

The Neuroscientist, Journal Year: 2022, Volume and Issue: 29(4), P. 393 - 420

Published: May 25, 2022

What is the role of brain’s ongoing activity for cognition? The predominant perspectives associate brain with resting state, default-mode network (DMN), and internally oriented mentation. This triad often contrasted task states, non-DMN networks, externally mentation, together comprising a “dual model” cognition. In opposition to this duality, however, we propose that serves as neuronal baseline; builds upon Raichle’s original search default mode function extended beyond canonical regions. That entails what refer “baseline model.” Akin an internal biological clock rest organism, may serve point reference or standard by providing shared neural code well including their associated Such manifest in spatiotemporal organization activity, its global signal topography dynamics like intrinsic timescales. We conclude recent empirical evidence supports baseline model over dual model; provides allows integrating DMN non-DMN,

Language: Английский

Citations

39