International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12908 - 12908
Published: Aug. 17, 2023
Memories
are
a
central
aspect
of
our
lives,
but
the
mechanisms
underlying
their
formation,
consolidation,
retrieval,
and
extinction
remain
poorly
understood.
In
this
review,
we
explore
molecular
memory
modulation
investigate
effects
RNA
on
these
processes.
Specifically,
examine
time
location
gene
expression
alterations.
We
then
discuss
potential
for
harnessing
alterations
to
modulate
memories,
particularly
fear
alleviate
post-traumatic
stress
disorder
(PTSD)
symptoms.
The
current
state
research
suggests
that
transcriptional
changes
play
major
role
in
targeting
them
through
microRNAs
may
hold
promise
as
novel
approach
treating
memory-related
disorders
such
PTSD.
Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 6, 2024
Abstract
It
has
been
well
established
that
a
consolidated
memory
can
be
updated
during
the
plastic
state
induced
by
reactivation.
This
updating
process
opens
possibility
to
modify
maladaptive
memory.
In
present
study,
we
evaluated
whether
fear
could
less-aversive
level
incorporating
hedonic
information
Thus,
male
rats
were
conditioned
and,
retrieval,
female
was
presented
as
social
rewarding
stimulus.
We
found
reactivation
with
(but
not
male)
reduces
expression
within-session
and
in
test,
without
presenting
reinstatement
or
spontaneous
recovery.
Interestingly,
this
intervention
impaired
extinction.
Finally,
demonstrated
emotional
remodeling
eliminate
requires
activation
of
dopamine
oxytocin
receptors
retrieval.
Hence,
these
results
shed
new
lights
on
suggests
exposure
natural
such
retrieval
previously
Frontiers in Behavioral Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Nov. 5, 2024
Social
interactions
are
fundamental
for
our
survival
as
a
predominately
social
species.
We
need
and
seek
positive
to
navigate
the
world.
However,
when
negative,
occur
in
presence
of
an
aversive
event,
learning
occurs
associate
such
threatening.
Gaining
insight
into
neural
circuits
that
drive
threat
is
crucial
understanding
interactions.
Animal
models
can
be
leveraged
employ
technologies
allow
us
track
neuronal
processes
with
very
high
resolution
obtain
better
involved.
To
accomplish
this,
we
robust
behavioral
replicable
throughput.
Here,
present
open-source
interaction
chamber
detects
automatically
pairs
it
foot
shock.
The
designed
easily
integrate
modular
chambers
commonly
used
auditory
context
learning.
It
contains
array
optical
gates
precisely
mouse-to-mouse
real
time
digital
triggers
communicate
external
devices
deliver
find
pairing
electric
shock
using
fully
automated
optimal
associations.
further
demonstrate
timing
contact
produces
The World Journal of Biological Psychiatry,
Journal Year:
2022,
Volume and Issue:
23(9), P. 653 - 665
Published: Jan. 10, 2022
Fear
memory
generalisation
is
a
central
hallmark
in
the
broad
range
of
anxiety
and
trauma-related
disorders.
Recent
findings
suggest
that
fear
closely
related
to
hippocampal
dependency
during
retrieval.
In
this
review,
we
describe
current
understanding
about
its
potential
influence
attenuation
through
pharmacological
behavioural
interventions.
light
systems
consolidation
framework,
propose
keeping
precision
could
be
key
step
enhance
therapeutic
outcomes.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 23, 2024
Abstract
Understanding
memory
formation
requires
elucidating
the
intricate
dynamics
of
neuronal
networks
in
hippocampus,
where
information
is
encoded
and
processed
through
specific
activity
patterns
synaptic
plasticity.
Here,
we
introduce
“EVOX,”
an
advanced
network
electrophysiology
platform
equipped
with
high-density
microelectrode
arrays
to
capture
critical
network-level
integral
learning
memory.
This
surpasses
traditional
methods
by
enabling
label-free,
high-order
mapping
neural
interactions,
providing
unprecedented
insights
into
Long-Term
Potentiation
(LTP)
evoked
transmission
within
hippocampal
network.
Utilizing
EVOX,
demonstrate
that
high-frequency
stimulation
induces
network-wide
LTP,
revealing
enhanced
efficacy
previously
inactive
cell
assemblies
layers.
Our
enables
real-time
observation
transmission,
capturing
connectivity
plasticity
underpin
encoding.
Advanced
computational
techniques
further
elucidate
mesoscale
transmembrane
generators
dynamic
processes
govern
encoding
mechanisms.
These
findings
uncover
complex
underlie
memory,
showcasing
EVOX’s
potential
explore
cellular
phenomena
aging
circuits.
EVOX
not
only
advances
our
understanding
mechanisms
but
also
serves
as
a
powerful
tool
investigate
broader
scope
interactions
healthy
diseased
states.
The
strength
of
a
fear
memory
significantly
influences
whether
it
drives
adaptive
or
maladaptive
behavior
in
the
future.
Yet,
how
mild
and
strong
memories
differ
underlying
biology
is
not
well
understood.
We
hypothesized
that
this
distinction
may
be
exclusively
result
changes
within
specific
brain
regions,
but
rather
outcome
collective
connectivity
across
multiple
regions
neural
network.
To
test
this,
rats
were
conditioned
protocols
varying
intensities
to
generate
memories.
Neuronal
activation
driven
by
recall
was
measured
using
cfos
immunohistochemistry
12
implicated
learning
memory.
interregional
coordinated
activity
computed
graph-based
functional
networks
generated
compare
at
systems
level.
Our
results
show
supported
well-connected
network
with
small-world
properties
which
amygdala
well-positioned
modulated
other
regions.
In
contrast,
disrupted
isolated
from
These
findings
indicate
differ,
implications
for
understanding
treating
disorders
dysregulation.
