Depletion of Fkbp5 Protects Against the Rapid Decline in Ovarian Reserve Induced by Prenatal Stress in Female Offspring of Wild-Type Mice

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2471 - 2471

Published: March 10, 2025

Prenatal stress (PNS) impairs offspring ovarian development by exerting negative long-term effects on postnatal function and folliculogenesis. FKBP51 is a stress-responsive protein that inhibits glucocorticoid progesterone receptors. We hypothesize contributes to impaired folliculogenesis induced PNS. Timed-pregnant Fkbp5+/+ (wild-type) Fkbp5−/− (knockout) mice were randomly assigned either the undisturbed (nonstress) or PNS group, with exposure maternal restraint from embryonic days 8 18. Ovaries harvested stained, follicles counted according their stages. Ovarian expressions of evaluated immunohistochemistry Fkbp5 steroidogenic enzymes qPCR. Compared controls, had increased peripubertal primordial follicle atresia fewer total in adult middle-aged groups. In offspring, elevated levels granulosa cells primary tertiary follicles. Our results suggest administration levels, depleted reserve, dysregulated steroid synthesis. However, these tolerated mice, supporting conclusion reduced reserve

Language: Английский

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Sex-specific metabolic and inflammatory alterations in adult animals vulnerable to prenatal stress exposure

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111344 - 111344

Published: March 1, 2025

Language: Английский

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A Critical Advantage of Hypnobirthing to Ameliorate Antenatal Depression: A Systematic Review and Meta-Analysis

Healthcare, Journal Year: 2025, Volume and Issue: 13(7), P. 705 - 705

Published: March 23, 2025

Pregnant women are likely to experience depression due various factors. Hypnobirthing is a non-invasive therapy that can be used treat during pregnancy. This study aims systematically review the effect of hypnobirthing on antenatal depression. employs systematic following PRISMA guidelines. Articles were retrieved from PubMed, ScienceDirect, Cochrane Library, Google Scholar, and hand searches. included for if they met inclusion criteria: (1) published in last ten years (2014-2024); (2) articles English; (3) article types original research reviews; (4) full text retrieved; (5) findings selected should discuss or hypnosis birth. critically appraised using Joanna Briggs Institute tools. The initial search yielded 7603 records; nine studies criteria review, four meta-analysis. analyzed, presented narrative ways categorized into three themes: therapy, administration mechanism therapy. was performed by different methods, involving hypnosis, daily relaxation, progressive muscle breathing exercises, J-breathing technique, meditation, visualization, ego strengthening. Additionally, participants encouraged do self-practice at home followed up personal visits, phone calls, messages. majority found ameliorated depression, despite variation duration Further needed standardize protocols explore long-term outcomes.

Language: Английский

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Exploring the potential of vagus nerve stimulation in treating brain diseases: a review of immunologic benefits and neuroprotective efficacy

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Oct. 19, 2023

Abstract The vagus nerve serves as a critical connection between the central nervous system and internal organs. Originally known for its effectiveness in treating refractory epilepsy, stimulation (VNS) has shown potential managing other brain diseases, including ischaemic stroke, traumatic injury, Parkinson's disease, Alzheimer's disease. However, precise mechanisms of VNS benefits diseases are not yet fully understood. Recent studies have found that can inhibit inflammation, promote neuroprotection, help maintain integrity blood-brain barrier, multisystemic modulatory effects, even transmit signals from gut flora to brain. In this article, we will review several essential summarize current theories immunomodulatory well therapeutic value disorders. By doing so, aim provide better understanding how neuroimmune network operates inspire future research field.

Language: Английский

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CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100631 - 100631

Published: March 27, 2024

To ensure the unrestricted expression of maternal behaviour peripartum, activity corticotropin-releasing factor (CRF) system needs to be minimised. CRF binding protein (CRF-BP) might crucial for this adaptation, as its primary function is sequester freely available and urocortin1, thereby dampening receptor (CRF-R) signalling. So far, role CRF-BP in brain has barely been studied, a potential curtailing activation stress axis unknown. We studied gene both CRF-R within paraventricular nucleus (PVN) hypothalamus. In lactating rats, Crh-bp parvocellular PVN was significantly higher Crh-r1 lower compared virgin rats. Acute inhibition with infusion CRF(6-33) increased basal plasma corticosterone concentrations under unstressed conditions dams. Furthermore, while acute intra-PVN secretion it ineffective vehicle (VEH)-pre-treated probably due buffering effect CRF-BP. Indeed, pre-treatment reinstated response highlighting critical maintaining attenuated reactivity lactation. our knowledge, first study linking hypothalamic hypothalamic-pituitary-adrenal regulation terms behaviour, non-stress reduced blanket nursing 60 min licking/grooming 90 after VEH-treated increasing aggression towards an intruder. Lastly, chronic strongly aggression, modest effects on motivation care. Taken together, intact during postpartum period essential dampened responsiveness axis, well full appropriate behaviour.

Language: Английский

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Calibration and recalibration of stress response systems across development: Implications for mental and physical health

Advances in child development and behavior, Journal Year: 2022, Volume and Issue: unknown, P. 35 - 69

Published: Jan. 1, 2022

Language: Английский

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Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3734 - 3734

Published: Feb. 13, 2023

Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, cognitive behavioural problems. Stress disrupts the homeostatic milieu of by altering inflammatory neuroendocrine mediators. These stress-induced phenotypic changes can be passed on offspring epigenetically. We investigated effects gestational chronic variable (CVS) in rats using restraint social isolation parental F0 generation its transgenerational transmission across three generations female (F1-F3). A subset F1 was housed an enriched environment (EE) mitigate CVS. found that CVS transmitted induces uterus. did not alter any lengths or weights. However, endocrine markers changed uterine tissues stressed mothers their offspring, suggesting transgenerationally transmitted. The F2 reared EE had increased but gene expression patterns remained comparable those animals. Thus, ancestral induced fetal programming over housing these effects.

Language: Английский

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Vulnerability and resilience to prenatal stress exposure: behavioral and molecular characterization in adolescent rats

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 22, 2023

Exposure to stress can lead long lasting behavioral and neurobiological consequences, which may enhance the susceptibility for onset of mental disorders. However, there are significant individual differences in outcome exposure since only a percentage exposed individuals show pathological whereas others appear be resilient. In this study, we aimed characterize effects prenatal (PNS) rats at adolescence identify subgroup animals with differential response gestational manipulation. PNS adolescent offspring (regardless sex) showed impaired emotionality different domains, such as anhedonia, anxiety, sociability. using cluster analysis data could 70% PNS-exposed vulnerable (PNS-vul), remaining 30% were considered resilient (PNS-res). At molecular level, found that PNS-res males reduced basal activation ventral hippocampus other regions, amygdala dorsal hippocampus, PNS-induced changes regardless from vulnerability or resilience. Taken together, our results provide evidence variability adolescence. While these advance understanding association between during gestation risk psychopathology, investigation mechanisms associated resilience instrumental develop novel strategies therapeutic intervention.

Language: Английский

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Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 371 - 371

Published: March 19, 2024

Exposure to early-life stress (ELS) has been related an increased susceptibility psychiatric disorders later in life. Although the molecular mechanisms underlying this association are still under investigation, glucocorticoid signaling proposed be a key mediator. Here, we used two preclinical models, prenatal (PNS) animal model and vitro of hippocampal progenitor cells, assess long-term effect ELS on FKBP5, NR3C1, NR3C2, FoxO1, four stress-responsive genes involved effects glucocorticoids. In hippocampus male PNS rats sacrificed at different time points during neurodevelopment (PND 21, 40, 62), found statistically significant up-regulation FKBP5 PND 40 62 increase FoxO1 62. Interestingly, all were significantly up-regulated differentiated cells treated with cortisol cell proliferation. As was consistently modulated by adolescence 40) adulthood 62) treatment after differentiation, measured panel miRNAs targeting same samples where expression levels available. both miR-20b-5p miR-29c-3p reduced PNS-exposed animals (both PND40 also exposure. Our results highlight role sustaining response system, representing mechanistic link possibly contributing enhanced stress-related vulnerability mental disorders.

Language: Английский

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Stress during pregnancy and fetal serum BDNF in cord blood at birth

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 165, P. 107035 - 107035

Published: March 27, 2024

Language: Английский

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