Using Features Extracted From Upper Limb Reaching Tasks to Detect Parkinson’s Disease by Means of Machine Learning Models DOI Creative Commons
Giuseppe Cesarelli, Leandro Donisi, Francesco Amato

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2023, Volume and Issue: 31, P. 1056 - 1063

Published: Jan. 1, 2023

While in the literature there is much interest investigating lower limbs gait of patients affected by neurological diseases, such as Parkinson's Disease (PD), fewer publications involving upper movements are available. In previous studies, 24 motion signals (the so-called reaching tasks) PD and Healthy Controls (HCs) were used to extract several kinematic features through a custom-made software; conversely, aim our paper investigate possibility build models - using these for distinguishing from HCs. First, binary logistic regression and, then, Machine Learning (ML) analysis was performed implementing five algorithms Knime Analytics Platform. The ML twice: first, leave-one out-cross validation applied; wrapper feature selection method implemented identify best subset that could maximize accuracy. achieved an accuracy 90.5%, demonstrating importance maximum jerk during subjects limb motion; Hosmer-Lemeshow test supported validity this model (p-value=0.408). first high evaluation metrics overcoming 95% accuracy; second perfect classification with 100% both area under curve receiver operating characteristics. top-five terms acceleration, smoothness, duration, kurtosis. investigation carried out work has proved predictive power features, extracted tasks limbs, distinguish HCs patients.

Language: Английский

Modern Methods of Diagnostics and Treatment of Neurodegenerative Diseases and Depression DOI Creative Commons
Natalia Shusharina, Denis Yukhnenko, Stepan Botman

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(3), P. 573 - 573

Published: Feb. 3, 2023

This paper discusses the promising areas of research into machine learning applications for prevention and correction neurodegenerative depressive disorders. These two groups disorders are among leading causes decline in quality life world when estimated using disability-adjusted years. Despite decades research, development new approaches assessment (especially pre-clinical) diseases remains priority neurophysiology, psychology, genetics, interdisciplinary medicine. Contemporary technologies medical data infrastructure create opportunities. However, reaching a consensus on application methods their integration with existing standards care is still challenge to overcome before innovations could be widely introduced clinics. The clinical predictions classification algorithms contributes towards creating unified approach use growing data. should integrate requirements professionals, researchers, governmental regulators. In current paper, state presented.

Language: Английский

Citations

56
Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction DOI Creative Commons
Yi Lü,

Faqian Bu,

Fang Wang

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Feb. 27, 2023

Abstract Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees benefits to cognitive function at all stages life cycle. Currently, with the aging world’s population and increase expectancy, dysfunction has gradually become a disease high incidence, which accompanied by neurodegenerative diseases in elderly individuals. Patients often exhibit memory loss, aphasia weakening orientation once diagnosed, are unable have normal life. Cognitive largely affects physical mental health, reduces quality life, causes economic burden society. At present, most interventions aimed maintain current level delay deterioration cognition. In contrast, as nonpharmacological therapy advantages its nontoxicity, low cost universal application. The molecular mechanisms underlying effect on cognition complex, studies been extensively centered neural plasticity, direct target brain. addition, mitochondrial stability energy metabolism essential brain status. Meanwhile, organ-brain axis responds induces release cytokines related this review, we summarize latest evidence effects cognition, point out directions future research.

Language: Английский

Citations

54
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms DOI Creative Commons
Jiao Wang, Jiayi Lin,

Yanfang Deng

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

Citations

5
Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases DOI Creative Commons

Ana Romero Garavito,

Vicente Martı́nez, Enric Cortés

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 28, 2025

This review explores the impact of physical exercise on brain-derived neurotrophic factor (BDNF) and its relationship with neurodegenerative diseases. The key role BDNF in maintaining brain health is highlighted, recent studies are analyzed that indicate an increase levels following activity, particularly young adults. Additionally, interaction between Val66Met genetic polymorphism cognitive function examined. emphasizes possibility as a complementary therapy for diseases, although further research required to fully understand effects.

Language: Английский

Citations

3
The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease DOI Creative Commons

Tibor Hortobágyi,

Tomáš Větrovský, Guilherme Moraes Balbim

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 80, P. 101698 - 101698

Published: July 16, 2022

To determine the effects of low- vs. high-intensity aerobic and resistance training on motor cognitive function, brain activation, structure, neurochemical markers neuroplasticity association thereof in healthy young older adults patients with multiple sclerosis, Parkinson's disease, stroke.Systematic review robust variance estimation meta-analysis meta-regression.Systematic search MEDLINE, Web Science, CINAHL databases.Fifty studies 60 intervention arms 2283 in-analyses participants were included. Due to low number studies, three patient groups combined analyzed as a single group. Overall, (g=0.19, p = 0.024) exercise (g=0.40, 0.001) improved neuroplasticity. Exercise intensity scaled only but not or groups. Exercise-induced improvements associated changes outcomes.Exercise is an important variable dose individualize stimulus for individuals necessarily neurological patients. This conclusion warrants caution because are needed that directly compare if such mechanistically incrementally linked cognition function.

Language: Английский

Citations

60
Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis DOI Creative Commons
Luis Carlos Venegas‐Sanabria, Iván Cavero‐Redondo, Vicente Martínez‐Vizcaíno

et al.

BMC Geriatrics, Journal Year: 2022, Volume and Issue: 22(1)

Published: July 25, 2022

Multicomponent physical exercise is the most recommended type of intervention in older adults. Experimental data suggest relevance muscle-brain axis and relationship between muscle contraction release brain-derived neurotrophic factor, however, impact this on cognition remains unclear, especially people with diagnosis cognitive impairment. This study assesses effect multicomponent global mild impairment or dementia.

Language: Английский

Citations

52
The Impact of Motor-Cognitive Dual-Task Training on Physical and Cognitive Functions in Parkinson’s Disease DOI Creative Commons
Yi Xiao,

Tianmi Yang,

Huifang Shang

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 437 - 437

Published: March 3, 2023

Rehabilitation is a high-potential approach to improving physical and cognitive functions in Parkinson’s disease (PD). Dual-task training innovatively combines motor rehabilitation comprehensive module. Patients perform tasks at the same time dual-task training. The previous studies of PD had high heterogeneity achieved controversial results. In current review, we aim summarize evidence effect on patients support clinical practice addition, also discuss opinions regarding mechanism underlying interaction between conclusion, suitable for with varied duration improve their function. can symptoms, single-task gait speed, steep length, balance, objective experience freezing PD. improvement function after mild.

Language: Английский

Citations

29
Does Exercise Attenuate Disease Progression in People With Parkinson’s Disease? A Systematic Review With Meta-Analyses DOI Creative Commons

Jiecheng A Li,

Marte B. Loevaas,

Catherine Guan

et al.

Neurorehabilitation and neural repair, Journal Year: 2023, Volume and Issue: 37(5), P. 328 - 352

Published: May 1, 2023

Introduction Exercise has many benefits for people with Parkinson’s disease (PD) and been suggested to modify PD progression, but robust evidence supporting this is lacking. Objective This systematic review (PROSPERO registration: CRD42020169999) investigated whether exercise may have neuroplastic effects indicative of attenuating progression. Methods Six databases were searched randomized controlled trials (RCTs) that compared the effect control (no or sham exercise) another form exercise, on indicators progression (eg, brain-derived neurotrophic factor [BDNF], brain activation, “off” Unified Disease Rating Scale [UPDRS] scores). Trial quality was assessed using Physiotherapy Evidence Database Scale. Random-effects meta-analyses performed where at least 3 comparable reported same outcome; remaining results synthesized narratively. Results Forty-nine involving 2104 participants included. Compared control, improved UPDRS motor scores (Hedge’s g −0.39, 95% CI: −0.65 −0.13, P = .003) BDNF concentration 0.54, 0.10-0.98, .02), low very certainty evidence, respectively. Narrative synthesis outcomes effects. The versus comparisons too heterogenous enable pooling results. Discussion provides limited an potential markers Further large RCTs are warranted explore differential by type, dose stage, should report a core set

Language: Английский

Citations

25
Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration DOI Creative Commons

Farhad Sanaeifar,

Sina Pourranjbar,

Mohammad Pourranjbar

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 195, P. 112539 - 112539

Published: Aug. 8, 2024

Neurodegenerative diseases (NDDs) are a class of neurological disorders marked by the progressive loss neurons that afflict millions people worldwide. These illnesses affect brain connection, impairing memory, cognition, behavior, sensory perception, and motor function. Alzheimer's, Parkinson's, Huntington's examples common NDDs, which frequently include buildup misfolded proteins. Cognitive-behavioral impairments early markers neurodevelopmental disorders, emphasizing importance detection intervention. Neurotrophins such as brain-derived neurotrophic factor (BDNF) critical for neuron survival synaptic plasticity, is required learning memory. NDDs have been associated with decreased BDNF levels. Physical exercise, non-pharmacological intervention, benefits health increasing levels, lowering cognitive deficits, slowing degradation. Exercise advantages increased well-being, reduced depression, improved skills, neuroprotection amyloid accumulation, oxidative stress, neuroinflammation. This study examines effects physical exercise on cognitive-behavioral deficits levels in limbic system impacted neurodegeneration. The findings highlight necessity including into NDD treatment to improve structure, function, total As research advances, becoming increasingly acknowledged an important technique treating decline neurodegenerative disorders.

Language: Английский

Citations

13
Changes of brain-derived neurotrophic factor (BDNF) levels after different exercise protocols: a systematic review of clinical studies in Parkinson’s disease DOI Creative Commons

Andrea Paterno,

Giovanni Polsinelli, Bruno Federico

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Background: Brain-Derived Neurotrophic Factor (BDNF) serum levels are reduced in patients with Parkinson’s Disease (PD). Objectives: This study aimed to assess the effect of exercise intensity, volume and type on BDNF PD. Methods: We searched clinicaltrials.gov, CINAHL, Embase, PubMed, Scopus, Web Science for both controlled non-controlled studies PD, published between 2003 2022, which assessed before after different protocols. Exercise intensity was estimated using a time-weighted average Metabolic Equivalent Task (MET), while by multiplying MET duration exercise. types were classified as aerobic, resistance, balance others. computed two distinct standardized measures effects: Hedges’ g estimate differences experimental control group pre-post intervention changes, Cohen’s d measure changes values each arm. Meta-regression linear regression used whether these associated type. PROSPERO registration number: CRD42023418629. Results: Sixteen (8 two-arm trials 8 single-arm trials) including 370 PD eligible systematic review. Selected had large variability terms population characteristics. The meta-analysis showed significant improvement compared group, = 0.70 (95% CI: 0.03, 1.38), substantial heterogeneity (I 2 76.0%). Between-group positively change subset 5 studies. In analysis included studies, total change. No difference found according Conclusion: Exercises greater may increase role needs be further explored.

Language: Английский

Citations

10