E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(2)

Published: Feb. 21, 2025

Language: Английский

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Monitoring of mental health in occupational populations: a study on the role and application of HDL-related inflammatory index

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 31, 2025

Mental disorders in occupational populations pose significant health and economic burdens, but there exists a lack of practical objective biomarkers for mental monitoring. Our study aims to explore the correlation between high-density lipoprotein (HDL)-related inflammatory markers negative psychological symptoms populations. We also seek evaluate potential application effectiveness these indicators as identifying impact on Moreover, found this can be used high-risk groups prone responses caused by symptoms. adopted cross-sectional design with combination questionnaires biochemical index tests 1920 eligible The Depression Anxiety Stress Scales-21 (DASS-21) was measure participants' levels anxiety, depression, stress. Collect individual characteristics survey respondents through self-administered questionnaires. Blood samples are collected cholesterol peripheral blood cell counts. employed statistical analyses including analysis, Receiver Operating Characteristic (ROC) curve univariate multivariate regression. final sample size included analysis 1,434. results showed that stress, depressive were significantly correlated all four HDL-related indices (p < 0.05). Especially MHR, compared those without symptoms, individuals experiencing or depression had an OR 2.75 (95% CI: 1.90, 3.99), 3.27 2.25, 4.78), 3.02 2.08, 4.40) abnormally high levels, respectively. In addition, subgroup lower monthly incomes, longer working hours frequent night shifts might promoting factors elevated levels. further demonstrated PHR MHR exhibit good predictive ability three AUC values exceeding 0.6. Notably, over 30 years work experience, performance is even higher, reaching above 0.7. suggest expected problems groups, providing valuable information assessment. Preventive measures should implemented low income, long hours, shifts, mitigate impacts.

Language: Английский

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Serum Exosomal hsa-miR-142-5p, hsa-miR-1908-5p, and hsa-miR-450b-5p as Candidate Biomarkers for Recurrent Depressive Disorder Diagnosis and ECT Treatment Response: A Preliminary Investigation

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111345 - 111345

Published: April 1, 2025

Language: Английский

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Exploring depression in adults over a decade: a review of longitudinal studies

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Depression, as a prevalent global mental health disorder, stands one of the main causes disability worldwide, imposing significant individual, societal, and economic burdens. While its heterogeneous nature is well recognized, growing evidence highlights importance understanding depression trajectories, which describe long-term course variability depressive symptoms over time. These trajectories are shaped by complex interplay biological, psychological, social factors. However, despite extensive research on depression's prevalence risk factors, comprehensive synthesis trajectory patterns, their determinants, implications remains limited. This review systematically examines existing literature in adults, identifying key influences such age, gender, socioeconomic status, early life experiences, support, physical health, lifestyle external stressors, including pandemics. By integrating findings from longitudinal epidemiological studies, this provides novel insights into bidirectional relationship between chronic conditions, underscoring need for holistic, trajectory-based approach to care. The have important clinical practice, public future research. Recognizing distinct patterns may facilitate earlier identification high-risk individuals, inform development personalized interventions, optimize allocation resources. Furthermore, elucidating interconnections broader establishes foundation advancing targeted, evidence-based interventions aimed at reducing burden depression, particularly among vulnerable populations.

Language: Английский

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Differential impacts of high-intensity interval training and moderate-intensity continuous training on obesity-induced behavioral and biochemical dysregulation in male mice

Sport Sciences for Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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