Food Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
Flavonoids
are
a
major
class
of
polyphenolic
compounds
that
occur
naturally
in
plants
and
widely
distributed
various
dietary
products.
exhibit
prominent
physicochemical
properties
biological
activities,
thereby
garnering
considerable
attention.
Notably,
the
functionalities
flavonoids
structurally
dependent.
Variations
chemical
structure
lead
to
differences
characteristics
among
different
flavonoid
types.
Structural
alterations
can
modify
these
characteristics,
influencing
activities
mechanisms
action.
However,
structural
variations
their
implication
have
not
been
comprehensively
elucidated.
In
this
review,
we
outline
flavonoids,
discuss
biosynthesis,
vivo
digestion,
absorption,
particularly
emphasize
diverse
action
associated
with
structures.
By
summarizing
current
scientific
findings,
aim
elucidate
structure–activity
relationships
provide
theoretical
basis
for
development
new
applications,
which
will
help
target
design
functional
molecules
moieties
food
pharmaceutical
industries
use
drug
development.
Practical
Application
:
Understanding
guide
products
supplements
targeted
health
benefits.
leveraging
knowledge
relationships,
food,
innovate
formulations
enhance
bioavailability
efficacy,
potentially
leading
creation
tailored
specific
conditions
or
needs.
This
research
lays
groundwork
novel
flavonoid‐based
interventions
aimed
at
promoting
human
well‐being.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 1695 - 1709
Published: Aug. 1, 2022
Abstract:
The
narrative
for
this
overview
focuses
on
updating
the
factors
that
influence
skin
aging
and
important
role
estrogens
selective
estrogen
receptor
modulators
(SERMs)
play
in
process
(mainly
utilizing
journal
reports
reviews
from
last
four
years).
Estrogens
have
been
known
studied
over
a
century.
For
many
years,
it
has
recognized
are
maintenance
of
human
skin.
Women
seek
cosmetic
medical
treatments
to
improve
dermal
health
physical
characteristics
enhance
their
self-perception
inhibit
aging,
particularly
highly
visible
body
areas.
goal:
retain
estrogen's
positive
benefits
while
especially
at/after
menopause
where
estrogen-deficient
contributes
dramatic
decline
health.
In
overview,
both
background
information
recent
novel
findings
included
cover
(general
mechanisms),
(intrinsic,
extrinsic,
microbiome
gut
microbiome.)
Plus,
general
maintaining
is
presented
through
classical
receptors
alpha
(α)
beta
(β)
non-classical
(or
non-genomic)
(G
protein-coupled
seven
transmembrane
receptor).
More
importantly,
various
17β-estradiol
examined
(ie,
collagen
elastin
profiles
follow
levels
during
menopause).
Finally,
revision
estrogenic
topical
applications
involving
isoflavonoid
compounds
act
as
SERMs,
but
classified
endocrine
disruptors,
analog
explored
update
unknown
these
treatments.
Further
study
warranted
understand
biological
molecular
mechanisms
by
which
support
wellbeing.
Keywords:
estrogens,
receptors,
isoflavonoid,
Animal Science Journal,
Journal Year:
2023,
Volume and Issue:
94(1)
Published: Jan. 1, 2023
Previous
studies
found
that
rutin
can
improve
production
performance
of
sheep
and
dairy
cows.
However,
it
is
not
clear
whether
has
similar
effects
in
goats.
Hence,
the
aim
this
experiment
was
to
study
supplementation
on
growth
performance,
slaughter
serum
parameters,
meat
quality
Nubian
A
total
36
healthy
ewes
were
randomly
divided
into
three
groups.
Goats
fed
basal
diet
supplemented
with
0
(R0),
25
(R25),
50
(R50)
mg
per
kg
diet.
The
goats
had
no
significant
difference
among
pH45min
moisture
significantly
higher
R25
group
than
R50
(p
<
0.05),
but
color
value
b*
contents
C14:0,
C16:0,
C18:0,
C18:1n9c,
C20:1,
saturated
fatty
acid
(SFA),
monounsaturated
(MSFA)
an
opposite
outcome.
dressing
percentage
increasing
tendency
compared
R0
(0.05
p
0.10),
shear
force,
water
loss
rate
crude
protein
results.
In
conclusion,
could
affect
goats;
low
levels
possibly
quality.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(21), P. 7436 - 7436
Published: Nov. 5, 2023
Genistein
is
a
natural
compound
belonging
to
flavonoids,
having
antioxidant,
anti-inflammatory,
and
anti-neoplastic
properties.
considered
phytoestrogen.
As
such,
genistein
can
bind
estrogen
receptors
(ERα
ERβ),
although
with
lower
affinity
than
that
of
estradiol.
Despite
considerable
work,
the
effects
are
not
well
established
yet.
This
review
aims
clarify
role
on
female
male
reproductive
functions
in
mammals.
In
females,
at
high
dose,
diminishes
ovarian
activity
regulating
several
pathway
molecules,
such
as
topoisomerase
isoform
I
II,
protein
tyrosine
kinases
(v-src,
Mek-4,
ABL,
PKC,
Syk,
EGFR,
FGFR),
ABC,
CFTR,
Glut1,
Glut4,
5α-reductase,
PPAR-γ,
mitogen-activated
kinase
A,
histidine
kinase,
recently
circulating
RNA-miRNA.
The
effect
pregnancy
still
controversial.
males,
exerts
an
estrogenic
by
inducing
testosterone
biosynthesis.
interaction
both
synthetic
endocrine
disruptors
has
negative
testis
function.
positive
sperm
quality
debate.
conclusion,
potentially
beneficial
mechanisms
reproduction
females
males.
However,
this
dependent
species,
route,
time
administration.
Environment International,
Journal Year:
2024,
Volume and Issue:
183, P. 108428 - 108428
Published: Jan. 1, 2024
Estrogen,
being
an
essential
class
of
sex
hormone,
is
important
target
endocrine
disruption
chemicals.
It
well
known
that
environmental
disruptors
could
activate
or
inhibit
estrogen
receptors,
acting
as
agonists
antagonists,
and
thus
affect
the
circulating
concentrations.
Here,
we
report
enzyme-mediated
diradical
cross-coupling
reactions
between
alkylphenols
(e.g.,
2,4-di-tert-butylphenol
[DBP],
4-nonylphenol
[4-NP],
4-tert-octylphenol
[4-t-OP])
estrogens
estradiol
[E2])
generate
coupling
metabolites
disrupt
homeostasis.
Among
phenolic
xenobiotics,
screening
metabolic
products
revealed
had
highest
reaction
activities
generated
with
high
abundances
(DBP-O-E2,
4-t-OP-O-E2,
4-NP-O-E2).
The
were
catalyzed
by
cytochrome
P450
3A4
(CYP3A4)
verified
detection
in
general
populations.
In
vitro
vivo
exposures
together
CYP3A4
inhibition
demonstrated
phenols
E2
significantly
reduced
normal
levels
E2.
We
further
established
a
unique
spin-trapping-based
high-throughput
method
to
show
existence
diradicals
reaction.
Density
functional
theory
calculations
spin
aromatic
delocalization
was
fundamental
cause
rebound
barrier
sufficient
lifetime
phenoxy
radicals
enabled
triggered
P450.
identified
mechanistic
details
for
provide
novel
pathway
chemicals
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
Flavonoids
are
a
major
class
of
polyphenolic
compounds
that
occur
naturally
in
plants
and
widely
distributed
various
dietary
products.
exhibit
prominent
physicochemical
properties
biological
activities,
thereby
garnering
considerable
attention.
Notably,
the
functionalities
flavonoids
structurally
dependent.
Variations
chemical
structure
lead
to
differences
characteristics
among
different
flavonoid
types.
Structural
alterations
can
modify
these
characteristics,
influencing
activities
mechanisms
action.
However,
structural
variations
their
implication
have
not
been
comprehensively
elucidated.
In
this
review,
we
outline
flavonoids,
discuss
biosynthesis,
vivo
digestion,
absorption,
particularly
emphasize
diverse
action
associated
with
structures.
By
summarizing
current
scientific
findings,
aim
elucidate
structure–activity
relationships
provide
theoretical
basis
for
development
new
applications,
which
will
help
target
design
functional
molecules
moieties
food
pharmaceutical
industries
use
drug
development.
Practical
Application
:
Understanding
guide
products
supplements
targeted
health
benefits.
leveraging
knowledge
relationships,
food,
innovate
formulations
enhance
bioavailability
efficacy,
potentially
leading
creation
tailored
specific
conditions
or
needs.
This
research
lays
groundwork
novel
flavonoid‐based
interventions
aimed
at
promoting
human
well‐being.
