Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111081 - 111081
Published: July 14, 2024
Language: Английский
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)
Published: Feb. 1, 2024
Abstract Aim Widely used second‐generation antipsychotics are associated with adverse metabolic effects, contributing to increased cardiovascular mortality. To develop strategies prevent or treat preclinical models have a clear role in uncovering underlying molecular mechanisms. However, few exceptions, studies been performed healthy animals, neglecting the contribution of dysmetabolic features inherent psychotic disorders. Methods In this study, methylazoxymethanol acetate (MAM) was prenatally administered pregnant Sprague–Dawley rats at gestational day 17 induce well‐validated neurodevelopmental model schizophrenia mimicking its assumed pathogenesis persistent phenotype. Against background, effects acute treatment olanzapine and haloperidol were examined female rats. Results Prenatally MAM‐exposed animals exhibited several features, including lipid disturbances. Half MAM exposed had pronounced serum profile alteration compared non‐MAM controls, interpreted as reflection delicate MAM‐induced balance disrupted by olanzapine. accordance drugs' clinical profiles, olanzapine‐associated more than haloperidol‐associated MAM. Conclusion Our results demonstrate vulnerability rats, indicating that findings from likely provide an underestimated impression dysfunction antipsychotics. context disturbances, possess relevant search for adequate animal should receive attention within field experimental psychopharmacology.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2786 - 2786
Published: Feb. 28, 2024
MicroRNAs (miRNAs) play a crucial role in the regulation of gene expression levels and have been implicated pathogenesis autism spectrum disorder (ASD) schizophrenia (SCZ). In this study, we examined adult profiles specific miRNAs prefrontal cortex (PFC) neurodevelopmental mouse model for ASD SCZ that mimics perinatal pathology, such as NMDA receptor hypofunction, exhibits behavioral neurophysiological phenotypes related to these disorders during adulthood. To early neuropathogenesis disorders, pups were administered subcutaneously with ketamine (30 mg/Kg) at postnatal days 7, 9, 11. We focused on set most frequently altered (miR-451a miR-486-3p) (miR-132-3p miR-137-3p) according human studies. Additionally, explored whose alterations identified both (miR-21-5p, miR-92a-2-5p, miR-144-3p, miR-146a-5p). placed particular emphasis studying sexual dimorphism dynamics miRNAs. Our findings revealed significant PFC ASD- SCZ-like model. Specifically, observed upregulated miR-451a downregulated miR-137-3p. Furthermore, miR-132-3p, miR-137-3p, miR-92a-2-5p. From translational perspective, our results emphasize potential involvement pathophysiology strengthen their biomarkers therapeutic targets disorders.
Language: Английский
Citations
3
BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)
Published: Aug. 29, 2023
Recent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) pro-inflammatory compounds, plays a significant role in developing illness. The study aimed to evaluate serum expression miRNA-26a, miRNA-106a, miRNA-125b as genetic factors levels IL-6, IL-1β, TNF-α an IranianAzeri population.Forty patients with recent-onset non-affective psychosis 40 healthy people control group were involved. Expression miRNAs cytokines measured using RT-qPCR ELISA, respectively. T-test, receiver operating characteristics (ROC), spearman correlation coefficient carried out data analysis.Findings higher TNF-α, miR-26a, miR-106a plasma patients' compared control. miRNA-26a statistically level (p < .003) group, AUC = 0.84 (95% CI: 0.77 0.93, P .001) cut-off point 0.17 comparison mentioned above; this regard, it might be suggestive biomarker for early stage Moreover, miRNAs' was not substantially associated any above.miR-26a Given relationship between is yet well understood; accordingly, there are encouragement support continued research fascinating field.
Language: Английский
Citations
8
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 26, 2024
This review examines the substantial involvement of Single Nucleotide Polymorphisms (SNPs) and microRNAs (miRNAs) in etiology susceptibility to Schizophrenia, with particular emphasis on dopaminergic, glutamatergic, GABAergic systems. It elucidates potential SNPs disrupt miRNA-mRNA interactions, leading alterations regulatory mechanisms Schizophrenia risk genes subsequently influencing Schizophrenia. Specific attention is given impact DICER, DROSHA , DGCR8 as well for changes DRD2 gene expression driven by miR-9 miR-326, heightening likelihood development. Furthermore, explores genetic glutamatergic system, focusing modifications linked GRIN2A its associated miRNAs, which have been reported a notable occurrence Knowledge within miRNAs essential GABA system are emerging described this review, including their consequences
Language: Английский
Citations
2
Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(9)
Published: Sept. 24, 2024
Atrial fibrillation (AF) is a common phenomenon of sustained arrhythmia leading to heart failure or stroke. Patients with mental disorders (MD), particularly schizophrenia and bipolar disorder, are at high risk AF triggered by the dysregulation autonomic nervous system, atrial stretch, oxidative stress, inflammation, electrical structural remodeling. Moreover, pathophysiological mechanisms underlying MD may also contribute genesis AF. An overactivated hypothalamic–pituitary–adrenal axis, aberrant renin–angiotensin–aldosterone abnormal serotonin signaling, disturbed sleep, genetic/epigenetic factors can adversely alter electrophysiology substrates, development In this review, we provide an update our collective knowledge molecular that link Targeting pathogenic MD-specific facilitate therapeutics mitigate cardiovascular mortality in patient population.
Language: Английский
Citations
2
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 6, 2024
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116294 - 116294
Published: April 3, 2024
Particulate matter (PM), released into the air by a variety of natural and human activities, is key indicator pollution. Although PM known as extensive health hazard to affect illness, few studies have specifically investigated effects PM10 exposure on schizophrenic development. In present study, we aimed investigate impact MK-801, N-methyl-D-aspartate (NMDA) receptor antagonist, induced schizophrenia-like behaviors in C57BL/6 mouse. Preadolescent mice were exposed 3.2 mg/m3 concentration for 4 h/day 2 weeks through compartmentalized whole-body inhalation chamber. After exposure, conducted behavioral tests during adolescence adulthood longitudinal development schizophrenia. We found that exacerbated behavior, such psychomotor agitation, social interaction deficits cognitive at MK-801-induced schizophrenia animal model. Furthermore, reduced expression levels brain-derived neurotrophic factor (BDNF) phosphorylation BDNF related signaling molecules, extracellular signal-regulated kinase (ERK) cAMP response element-binding protein (CREB), adult hippocampus MK-801-treated mice. Thus, our study demonstrates preadolescence exacerbates impairment model schizophrenia, which are considered be facilitated decreased level ERK-CREB expression.
Language: Английский
Citations
2
Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 472, P. 115149 - 115149
Published: July 14, 2024
Language: Английский
Citations
2
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5728 - 5728
Published: Sept. 2, 2023
The main aim of this systematic review and meta-analysis is to establish whether there a correlation between the brain-derived neurotrophic factor (BDNF) level electroconvulsive therapy (ECT) treatment reduction in psychotic symptoms patients diagnosed with schizophrenia. A search PubMed/Medline, Cochrane Library, Web Science, Scopus Embase was conducted up March 2023. Inclusion criteria: studies which adult schizophrenia treated antipsychotic medication received ECT had BDNF measured before after treatment. Exclusion animal vitro or not involving complete information about concentration plasma. risk bias assessed using Egger’s regression-based test for continuous outcomes. Six comprising 248 individuals were included. statistically significant increase levels observed only two (p < 0.001 p 0.027, respectively), whereas four other studies, an upward trend without statistical significance noticed. estimated overall size effect revealed that caused slight change but (ES = −0.328). Different numbers procedures (4-10), final measurement made at different time point, bilateral unilateral electrode positioning during combinations typical atypical medications may be potential reasons lack changes Data regarding pre post are very limited extended follow-up period evaluation mental health change. Our showed increases serum drug-resistant compared only; however, significant.
Language: Английский
Citations
5
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155102 - 155102
Published: Jan. 9, 2024
Language: Английский
Citations
1