Integrating Threat Conditioning and the Hierarchical Taxonomy of Psychopathology (HiTOP) to Advance the Study of Anxiety-Related Psychopathology DOI Open Access
Samuel E. Cooper, Emily R. Perkins, Ryan Webler

et al.

Published: Oct. 27, 2023

Theoretical and methodological research on threat conditioning provides important neuroscience-informed approaches to studying fear anxiety. The framework is at the vanguard of physiological neurobiological into core mechanistic symptoms anxiety-related psychopathology, providing detailed models neural circuitry underlying variability in clinically-relevant behaviors (e.g., decreased extinction, heightened generalization) heterogeneity clinical anxiety presentations. Despite strengths approach explaining symptom-level syndromal heterogeneity, vast majority psychopathology-oriented work has been conducted using Diagnostic Statistical Manual (DSM) paradigm. Unfortunately, DSM categorizations fail capture resolution afforded by indices. Further, relations between fine-grained neurobehavioral measures specific are substantially attenuated within-category arbitrary boundaries, comorbidity, limited reliability DSM. Conversely, Hierarchical Taxonomy Psychopathology (HiTOP) a promising for modeling studied relating broader constructs. To date, HiTOP had minimal impact field. Here, we propose that combining an next step pathology. We provide brief review prominent critiques how they affect studies suggest solutions recommendations flow from perspective. Our hope this effort serves as both inflection point practical primer HiTOP-aligned benefits fields.

Language: Английский

Understanding clinical fear and anxiety through the lens of human fear conditioning DOI Open Access
Tom Beckers, Dirk Hermans, Iris Lange

et al.

Nature Reviews Psychology, Journal Year: 2023, Volume and Issue: 2(4), P. 233 - 245

Published: Feb. 16, 2023

Language: Английский

Citations

84
Renewal in human fear conditioning: A systematic review and meta-analysis DOI Creative Commons
Yi Wang,

Sarah Olsson,

Ottmar V. Lipp

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 159, P. 105606 - 105606

Published: Feb. 29, 2024

Renewal is a 'return of fear' manipulation in human fear conditioning to investigate learning processes underlying anxiety and trauma. Even though renewal paradigms are widely used, no study has compared the strength different paradigms. We conduct systematic review (N = 80) meta-analysis 23) studies assessing renewal. Our analysis shows that classic ABA design most effective paradigm, ABC ABBA designs. present evidence conducting extinction multiple contexts increasing similarity between acquisition reduce Furthermore, we show additional cues can be used as safety 'protection from extinction' cues. The alcohol weakens process older adults appear less sensitive context changes thus large variability approaches humans suggests standardisation procedures across laboratories would great benefit field.

Language: Английский

Citations

9
Fear extinction retention in children, adolescents, and adults DOI Creative Commons
Ebba Widegren, Johan Vegelius, Matilda A. Frick

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 71, P. 101509 - 101509

Published: Jan. 1, 2025

Language: Английский

Citations

1
Fear conditioning depends on the nature of the unconditional stimulus and may be related to hair levels of endocannabinoids DOI Creative Commons
Luke J. Ney, David S. Nichols, Ottmar V. Lipp

et al.

Psychophysiology, Journal Year: 2023, Volume and Issue: 60(8)

Published: March 23, 2023

Abstract The replicability of fear conditioning research has come under recent scrutiny, with increasing acknowledgment that the use differing materials and methods may lead to incongruent results. Direct comparisons between main two unconditional stimuli used in – an electric shock or a loud scream—are scarce, yet these are usually interchangeably. In present study, we tested whether scream, shock, unpredictable combination affected acquisition, extinction, return amongst healthy participants ( N = 109, 81 female). We also collected hair samples relationship endocannabinoid levels. Our findings suggest that, although subjective ratings pleasantness, arousal, anxiety were similar regardless used, skin conductance responses significantly lower for paired scream compared alone. Further, reducing predictability stimulus reduced habituation during acquisition reacquisition, but did not produce stronger Exploratory analyses suggested endocannabinoids associated overall physiological arousal conditioning, as well higher threat cue, safety cue. These have multiple implications design provide first evidence association levels human conditioning.

Language: Английский

Citations

11
The impact of temporal distribution on fear extinction learning DOI Creative Commons

Yuanbo Ma,

Dzheylyan Kyuchukova,

Fujia Jiao

et al.

International Journal of Clinical and Health Psychology, Journal Year: 2025, Volume and Issue: 25(1), P. 100536 - 100536

Published: Jan. 1, 2025

Fear extinction is the foundation of exposure therapy for anxiety and phobias. However, stability memory diminishes over time, coinciding with fear recovery. To augment long-term retention, temporal distribution learning sessions critical. This study investigated effects massed spaced training (with short long intervals) on retention compared to a classic protocol. 120 healthy participants were recruited randomly divided training, 20-minutes or 3-hours intervals, control group. The group completed half number trials other groups. conditioning/extinction paradigm consisted three consecutive days acquisition, extinction, recall, followed by second recall one week later. Skin conductance response (SCR) self-rating questionnaires (ratings valence, arousal, fear) recorded analyzed using mixed model ANOVAs. results revealed that during phase, both protocols showed significantly lower SCRs group, resulting in largest effects. In only no significant difference between threat safety cues. self-report assessments indicated furthermore arousal than first recall. These suggest promote learning, but improves retention. highlights impact trial offering insights future research improving efficacy.

Language: Английский

Citations

0
Modulation of Fear Extinction by Non‐Invasive Brain Stimulation: Systematic Review and Meta‐Analysis DOI Open Access
Zhang Ye, Jingyuan Lin, Haoran Dou

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(2)

Published: Feb. 1, 2025

ABSTRACT Non‐invasive brain stimulation (NIBS) is an emerging treatment for mental disorders that painlessness and easy to administer. However, its effectiveness modulating fear extinction requires further elucidation. We searched eight bibliographical databases identified randomized controlled trials of NIBS in healthy populations. Outcomes were evaluated based on skin conductance responses (SCRs) under three experimental stimuli: threat condition (CS+), safe (CS−), their discrimination (CS+ minus CS−). applied a random‐effects model determine effect sizes (Hedge's g ) post‐stimulation assessed article quality using Physiotherapy evidence database (PEDro) scale. Twenty‐one studies meeting systematic review criteria included this analysis, incorporating 40 independent data from 11 ( n = 632) the meta‐analysis. Compared with control group, SCRs CS+ significantly reducted intervention group. Fear was more effective 24‐h test than immediately after NIBS. In conclusion, enhanced extinction, time interval between testing may serve as moderating variable.

Language: Английский

Citations

0
Calibration experiments: An alternative to multi-method approaches for measurement validation in consumer research DOI Creative Commons
Dominik R. Bach, Edward E. Rigdon, Marko Sarstedt

et al.

Journal of Business Research, Journal Year: 2025, Volume and Issue: 193, P. 115352 - 115352

Published: April 1, 2025

Language: Английский

Citations

0
Generalization of exposure therapy: Systematic review and recommendations for future research DOI
Iris Kodzaga,

Jan Heistermann,

Armin Zlomuzica

et al.

Behaviour Research and Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104751 - 104751

Published: April 1, 2025

Language: Английский

Citations

0
Adaptive thresholding increases sensitivity to detect changes in the rate of skin conductance responses to psychologically arousing stimuli in both laboratory and ambulatory settings DOI
Ian R. Kleckner, Jolie B. Wormwood, Rebecca M. Jones

et al.

International Journal of Psychophysiology, Journal Year: 2023, Volume and Issue: 196, P. 112280 - 112280

Published: Dec. 15, 2023

Language: Английский

Citations

7
Pavlovian or associative sensitization and its biological significance DOI Creative Commons
Michael Domjan, Michael S. Fanselow

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105790 - 105790

Published: July 2, 2024

Pavlovian conditioning is typically distinguished from sensitization but a conditional stimulus (CS) also results in sensitization. A CS can sensitize responding to probe that related the unconditional (US) or US itself. has been studied defensive, sexual, and feeding systems. In sensitization, focus not on response (CR) directly elicited by mode activated CS. Activation of increases probability particular responses reactivity various stimuli. reflects this increased reactivity. helps uncover successful learning situations where conventional CR does occur. encourages broadening our conceptions include changes afferent processes. Implications for biological fitness basic translational research are discussed.

Language: Английский

Citations

2