Existential aspects of breathlessness in serious disease DOI

David Baglow,

Kylie Johnston, Marie Williams

et al.

Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: 18(4), P. 183 - 190

Published: Oct. 30, 2024

Purpose of the review Breathlessness may evoke existential threat but also affect person with serious illness or their caregiver/s in other important ways which can be considered ‘existential’. This explores aspects breathlessness people and presents recent studies assessment management associated distress suffering. Recent findings Both are multidimensional include a range constructs, many have behavioural consequences. Existential tracks closely distressing breathing potentially due to shared underlying neurobiological processing. Paradoxically ‘contagious’ isolating effects related been recently highlighted. Approaches screening vary. Preliminary investigated novel approaches breathing-related anxiety distress. Summary Studies constructs as outcome measures scarce. Interventions for developed those malignant disease beneficial non-malignant conditions, adaptations required. Recently proposed taxonomies distress/concerns guide direct therapeutic interventions living breathlessness-related Neglecting represents missed opportunity support holistic well-being illness.

Language: Английский

Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum DOI Creative Commons
Rany Abend

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105305 - 105305

Published: July 5, 2023

Language: Английский

Citations

42
Affective Neuroscience DOI Creative Commons
Dean Mobbs

MIT Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Citations

11
Understanding the heterogeneity of anxiety using a translational neuroscience approach DOI Creative Commons

Carly M. Drzewiecki,

Andrew S. Fox

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 24(2), P. 228 - 245

Published: Feb. 14, 2024

Abstract Anxiety disorders affect millions of people worldwide and present a challenge in neuroscience research because their substantial heterogeneity clinical presentation. While great deal progress has been made understanding the neurobiology fear anxiety, these insights have not led to effective treatments. Understanding relationship between phenotypic underlying biology is critical first step solving this problem. We show translation, reverse computational modeling can contribute refined, cross-species anxiety as well disorders. More specifically, we outline how animal models be leveraged develop testable hypotheses humans by using targeted, approaches ethologically informed behavioral paradigms. discuss translational that guide prioritize nontraditional species. Finally, advocate for use harmonize cross-methodology into anxiety. Together, approach will help bridge widening gap currently conceptualize diagnose disorders, aid discovery better treatments conditions.

Language: Английский

Citations

9
Navigating the fear: assessing nursing students’ concerns and preventive practices in response to Monkeypox in Egypt DOI Creative Commons
Shaimaa Mohamed Amin, Doaa El Demerdash,

Mona Metwally El‐Sayed

et al.

BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 7, 2025

Abstract Background Monkeypox has emerged as a global health concern, necessitating preventive measures and awareness among healthcare students. Understanding nursing students’ fears, concerns, practices regarding can help improve preparedness response strategies. Aim This study aimed to assess the levels of fear, related monkeypox students at Beni Suef University, Egypt, during 2024–2025 academic year. Methods A cross-sectional descriptive design was employed, involving 505 systematically randomized recruited. Data collection utilized three validated tools: Fear Scale, Concern Preventive Practices Scale. Reliability confirmed with Cronbach’s alpha values ranging from 0.87 0.94. analysis included statistics, Spearman correlation, multiple linear regression using SPSS Version 23. Results Most (56.2%) rarely worried about infection, though 49.2% reported anxiety influenced by media coverage. High were noted, 60.6% frequently practicing hygiene measures. strong positive correlation between concern fear ( r = 0.646, p < 0.001) moderate 0.229, 0.001). also significantly correlated 0.432, Multiple (R² 0.216, F 22.633, revealed that predictor practices, while had but non-significant effect (B 0.138, 0.156). Age not significant 0.251, 0.637), whereas family income showed negative association -1.885, 0.010). Conclusion The concerns students, generally high adherence practices. Implication Findings suggest need for targeted education programs address monkeypox-related enhance measures, thus improving readiness respond emerging threats.

Language: Английский

Citations

1
Neuropsychological Insights into Coping Strategies: Integrating Theory and Practice in Clinical and Therapeutic Contexts DOI Creative Commons
Maria Theodoratou, Marios Argyrides

Psychiatry International, Journal Year: 2024, Volume and Issue: 5(1), P. 53 - 73

Published: Feb. 4, 2024

The primary focus of this review is to rigorously explore the application and significance coping strategies within domains clinical psychology neuropsychology. These consist a variety techniques, behaviors, cognitive interventions, their critical role in reinforcing resilience facilitating adaptive responses stressors has been highlighted. This study explores complex neuropsychological links between brain’s stress pathways use mechanisms. neural aspects stress, how they can be influenced by strategies, are detailed, illustrating profound impact that these mechanisms have at neurobiological level. Delving into underpinnings, will shed light on response brain interact with, modulated by, various strategies. particularly salient when addressing multifaceted challenges faced individuals with or mental health issues. While span broad spectrum, from introspection reframing behavioral activation social support seeking, integration remain diverse contexts. endeavors elucidate theoretical underpinnings empirical support, practical implications therapeutic interventions. Furthermore, intricate interplay individualized techniques structured methodologies examined, emphasizing potential for holistic treatment paradigm, thereby enhancing outcomes fostering individual resilience.

Language: Английский

Citations

7
Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain DOI Creative Commons
Mirjam Bonanno,

Davide Papa,

Antonio Cerasa

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 285 - 285

Published: Feb. 7, 2024

Chronic stress and chronic pain share neuro-anatomical, endocrinological, biological features. However, prepares the body for challenging situations or mitigates tissue damage, while is an unpleasant sensation due to nociceptive receptor stimulation. When chronic, it might lead allostatic overload in brain dysregulation of physiological systems that are normally involved adapting environmental challenges. Managing (CP) neurorehabilitation presents a significant challenge healthcare professionals researchers, as there no definitive effective solution these issues. Patients suffering from neurological disorders often complain CP, which significantly reduces their quality life. The aim this narrative review examine correlation between potential negative impact on rehabilitation process. Moreover, we described most relevant interventions used manage population. In conclusion, sheds light connection pathway. Our results emphasize need tailored protocols effectively pain, improve treatment adherence, ensure comprehensive patient care.

Language: Английский

Citations

7
Distributed neural representations of conditioned threat in the human brain DOI Creative Commons

Zhenfu Wen,

Edward F. Pace‐Schott, Sara W. Lazar

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 12, 2024

Abstract Detecting and responding to threat engages several neural nodes including the amygdala, hippocampus, insular cortex, medial prefrontal cortices. Recent propositions call for integration of more distributed that process sensory cognitive facets related threat. Integrative, sensitive, reproducible decoders detection response safety have yet be established. We combine functional MRI data across varying conditioning negative affect paradigms from 1465 participants with multivariate pattern analysis investigate representations safety. The trained sensitively specifically distinguish between cues multiple datasets. further show many dynamically shift Our results establish integrate circuits, merging well-characterized ‘threat circuit’ nodes, discriminating regardless experimental designs or acquisition parameters.

Language: Английский

Citations

7
Fear, anxiety and the functional architecture of the human central extended amygdala DOI Creative Commons
Alexander J. Shackman, Shannon E. Grogans, Andrew S. Fox

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Language: Английский

Citations

6
Dynamic threat–reward neural processing under semi‐naturalistic ecologically relevant scenarios DOI Creative Commons
Daniel Levitas, Thomas W. James

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(4)

Published: March 1, 2024

Abstract Studies of affective neuroscience have typically employed highly controlled, static experimental paradigms to investigate the neural underpinnings threat and reward processing in brain. Yet our knowledge more naturalistic settings remains limited. Specifically, studies generally examine features separately under brief time periods, despite fact that nature organisms are often exposed simultaneous presence for extended periods. To study mechanisms distinct temporal profiles, we created a modified version PACMAN game included these environmental features. We also conducted two automated meta‐analyses compare findings from semi‐naturalistic paradigm those constrained experiments. Overall, results revealed distributed system regions sensitive imminence less related imminence, both which exhibited overlap yet neither involved amygdala. Additionally, systems broadly overlapped with corresponding meta‐analyses, notable absence amygdala findings. Together, suggest shared salience reveals heightened sensitivity toward threats compared rewards when simultaneously present an environment. The broad correspondence consisting tightly controlled paradigms, illustrates how can corroborate previous literature while potentially uncovering novel resulting nuances contexts manifest such dynamic environments.

Language: Английский

Citations

5
The impact of experiential avoidance on anxiety and depressive disorders in hematological cancer patients DOI Creative Commons

Gregor Weißflog,

Jochen Ernst, Peter Esser

et al.

Journal of Behavioral Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Anxiety disorders and/or depressive co-occurring with hematological cancer are an additional burden for patients. Experiential avoidance (EA; efforts to avoid negative emotions, thoughts, or memories) is empirically evident transdiagnostic factor the onset and maintenance of anxiety in non-cancer populations. There lack evidence on impact EA predicting depression A total 291 patients (60% male, mean age 55 years) were included this cross-sectional observational study. Participants assessed using Structured Clinical Interview DSM-5 mental (SCID-5). was via self-report Brief Avoidance Questionnaire (BEAQ). Hierarchical binomial logistic regression conducted order estimate disorders. 38 (13.3%) met diagnostic criteria a current disorder, while 49 (17.2%) disorder. In bivariate analyses, significantly elevated disorder comparison those without (54.4 vs. 48.9; p = 0.01). The same true (54.9 48.6; < After controlling relevant sociodemographic medical factors, did not predict separate models. presence predicted by female sex, younger comorbidity burden. contrast, Sociodemographic predictors have greater predictive potential than regarding

Language: Английский

Citations

0