The role of neutrophils in pain: systematic review and meta-analysis of animal studies DOI
Miguel Á. Huerta, Miguel Molina‐Álvarez, Miguel Ángel Martínez-García

et al.

Pain, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract The peripheral inflammatory response is an attractive therapeutic target for pain treatment. Neutrophils are the first circulating cells recruited to sites of injury, but their contribution outcomes unclear. We performed a systematic review and meta-analysis original preclinical studies, which evaluated effect preemptive neutrophil depletion on (PROSPERO registration number: CRD42022364004). Literature search (PubMed, January 19, 2023) identified 49 articles, were meta-analyzed using random-effects model. risk bias was SYRCLE's tool. pooled considering all studies showed that induced consistent reduction. Inflammatory, joint, neuropathic, visceral significant alleviation by with medium-large sizes. However, muscle postoperative not significantly alleviated depletion. Further analysis differential neutrophils outcomes. had higher impact mechanical hyperalgesia, followed nociceptive behaviors allodynia, smaller thermal hyperalgesia. Interspecies (mice or rats) differences appreciated. Analyses regarding intervention unveiled lower reduction some commonly used methods depletion, such as injection antineutrophil serum anti–Gr-1 antibody, than other agents administration anti-Ly6G fucoidan, vinblastine, CXCR1/2 inhibitors, etanercept. In conclusion, depends etiology (experimental model), outcome, strategy. research needed improve our understanding mechanisms these differences.

Language: Английский

Potential of N-acetylcysteine in the management of low back pain: a scoping review of studies in humans and animal models DOI Creative Commons
Giovana Sinigaglia, Lucas Marques Fortunato, Marcelo Lacerda Grillo

et al.

Brazilian Journal of Medical and Biological Research, Journal Year: 2025, Volume and Issue: 58

Published: Jan. 1, 2025

Low back pain (LBP) is a common type of that causes disability and impairs cognitive function. With over 80% adults estimated to experience LBP during their lifetime, this not only has significant impact on the individual, but also public health systems national economies. Unfortunately, there no single standard care for patients with LBP. N-acetylcysteine (NAC), which used clinically treat acetaminophen overdose, recently been tested as potential treatment NAC inexpensive commercially available, it an established tolerance safety profile. However, NAC's efficacy in established. This scoping review presents summary studies investigating effects benefits treatment, highlights its molecular mechanisms side effects. A systematic literature search Pubmed/MEDLINE, Embase, Scopus, Science Direct, Web Science, Cinahl, Lilacs databases was conducted. The PRISMA-ScR checklist ensure integrity review. protocol registered Open Framework. No limit set study language publication date. In total, 2357 articles were located, 16 included. show data are derived from few clinical trials preclinical studies. Thus, much learn more should be performed before can recommended

Language: Английский

Citations

0
Preclinical Animal Models to Investigate the Role of Nav1.7 Ion Channels in Pain DOI Creative Commons

Álvaro Yogi,

Umberto Banderali, María Moreno

et al.

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 640 - 640

Published: April 12, 2025

Chronic pain is a maladaptive neurological disease that remains major global healthcare problem. Voltage-gated sodium channels (Navs) are drivers of the excitability sensory neurons, and Nav subtype 1.7 (Nav1.7) has been shown to be critical for transmission pain-related signaling. This highlighted by demonstrations gain-of-function mutations in Nav1.7 gene SCN9A result various pathologies, whereas loss-of-function cause complete insensitivity pain. A substantial body evidence demonstrates chronic neuropathy inflammation an upregulation Nav1.7, suggesting this channel contributes sensation. As such, attractive human-validated target treatment Nonetheless, lack selectivity, insufficient efficacy, adverse reactions some issues have hindered Nav1.7-targeted drug development. review summarizes behavior profiles mediated reported multiple preclinical models, outlining current knowledge biophysical, physiological, distribution properties required inhibitor produce analgesia.

Language: Английский

Citations

0
Incorporación de la perspectiva de género en proyectos I+D+i en salud. Cuándo y cómo DOI
Isabel Ruiz‐Pérez, Guadalupe Pastor‐Moreno, Vivian Benítez‐Hidalgo

et al.

Medicina Clínica, Journal Year: 2025, Volume and Issue: 165(1), P. 106963 - 106963

Published: May 21, 2025

Citations

0
P2X3 and P2X2/3 Receptors Inhibition Produces a Consistent Analgesic Efficacy: A Systematic Review and Meta-Analysis of Preclinical Studies DOI Creative Commons
Miguel Á. Huerta, Daniel Marcos-Frutos, Javier de la Nava

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 984, P. 177052 - 177052

Published: Oct. 10, 2024

P2X3 and P2X2/3 receptors are promising therapeutic targets for pain treatment selective inhibitors under evaluation in ongoing clinical trials. Here we aim to consolidate quantitatively evaluate the preclinical evidence on treatment.

Language: Английский

Citations

2
Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis DOI Creative Commons
Miguel Á. Huerta, Miguel Á. Tejada, Francisco R. Nieto

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 290 - 290

Published: June 24, 2024

Fucoidan is a polymer of L-fucose and L-fucose-4-sulphate naturally found in marine sources that inhibits p-selectin, preventing neutrophil recruitment to the site injury. employed many studies as tool investigate contribution neutrophils pain, showing analgesic effects. We performed systematic review meta-analysis quantify effects pretreatment with fucoidan reported available preclinical studies. In addition, we summarized articles which have studied therapeutic pathological pain at clinical levels. The results this reveal powerful reduces infiltration by 70–90% early time points. This showed preventative treatment produced significant reduction. several observed associated various pathologies. Finally, has also been tested trials, some degree efficacy, but they were mostly small pilot Considering all above information, it can be concluded not only for studying role promising strategy treatment.

Language: Английский

Citations

0
The role of neutrophils in pain: systematic review and meta-analysis of animal studies DOI
Miguel Á. Huerta, Miguel Molina‐Álvarez, Miguel Ángel Martínez-García

et al.

Pain, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract The peripheral inflammatory response is an attractive therapeutic target for pain treatment. Neutrophils are the first circulating cells recruited to sites of injury, but their contribution outcomes unclear. We performed a systematic review and meta-analysis original preclinical studies, which evaluated effect preemptive neutrophil depletion on (PROSPERO registration number: CRD42022364004). Literature search (PubMed, January 19, 2023) identified 49 articles, were meta-analyzed using random-effects model. risk bias was SYRCLE's tool. pooled considering all studies showed that induced consistent reduction. Inflammatory, joint, neuropathic, visceral significant alleviation by with medium-large sizes. However, muscle postoperative not significantly alleviated depletion. Further analysis differential neutrophils outcomes. had higher impact mechanical hyperalgesia, followed nociceptive behaviors allodynia, smaller thermal hyperalgesia. Interspecies (mice or rats) differences appreciated. Analyses regarding intervention unveiled lower reduction some commonly used methods depletion, such as injection antineutrophil serum anti–Gr-1 antibody, than other agents administration anti-Ly6G fucoidan, vinblastine, CXCR1/2 inhibitors, etanercept. In conclusion, depends etiology (experimental model), outcome, strategy. research needed improve our understanding mechanisms these differences.

Language: Английский

Citations

0