Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113208 - 113208

Published: May 31, 2022

This study aimed to reveal the classical signal pathways and important potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD), provide support further investigation on TCM its active ingredients.Literature survey was conducted using PubMed, Web Science, Google Scholar, CNKI, other databases, with "Alzheimer's disease," "traditional medicine," "medicinal herb," "Chinese "natural plant" as primary keywords.TCM could modulate related AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, PI3K/Akt/mTOR, well SIRT1 PPARα pathway. It regulate crosstalk between through a multitarget, thus maintaining chronic inflammatory interaction balance, inhibiting oxidative stress damage, regulating system function, modulating autophagy, eventually improving cognitive impairment in patients AD.TCM be multilevel, multitargeted, multifaceted prevent treat AD. In-depth research prevention treatment new ideas exploring pathogenesis developing anti-AD drugs.

Language: Английский

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Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice

Phytomedicine, Journal Year: 2023, Volume and Issue: 113, P. 154725 - 154725

Published: Feb. 26, 2023

Language: Английский

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Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3169 - 3189

Published: April 14, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid‐beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, polyphenolic compound derived from Curcuma longa , has shown potential neuroprotective effects due its anti‐inflammatory antioxidant properties. This review aims synthesize current preclinical data on anti‐neuroinflammatory mechanisms curcumin in context AD, addressing pharmacokinetics, bioavailability, as therapeutic adjunct. An exhaustive literature search was conducted, focusing recent studies within last 10 years related curcumin's impact neuroinflammation role AD. The methodology included sourcing articles specialized databases using specific medical subject headings terms ensure precision relevance. Curcumin demonstrates significant properties modulating neuroinflammatory pathways, scavenging reactive oxygen species, inhibiting production pro‐inflammatory cytokines. Despite potential, challenges remain regarding limited bioavailability scarcity comprehensive human clinical trials. emerges promising adjunct AD multimodal benefits. However, further research required overcome establish effective dosing regimens subjects. Developing novel delivery systems formulations may enhance treatment.

Language: Английский

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The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease

Neurochemistry International, Journal Year: 2022, Volume and Issue: 156, P. 105325 - 105325

Published: March 9, 2022

Language: Английский

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Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 24, 2022

Parkinson's disease (PD) is one of the most common and chronic degenerative diseases in central nervous system. The main pathology PD formation progressive loss dopaminergic neurons substantia nigra α-synuclein-rich Lewy bodies. pathogenesis not caused by any single independent factor. diversity these factors PD, such as iron accumulation, oxidative stress, neuroinflammation, mitochondrial dysfunction, age, environment, heredity, makes research progress slow. Nrf2 has been well-known to be closely associated with could regulate induced development. activation protect slow down progression PD. This review summarized role pathway on Regulation might promising strategies prevent treat

Language: Английский

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The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Neurochemistry International, Journal Year: 2022, Volume and Issue: 158, P. 105376 - 105376

Published: June 3, 2022

Language: Английский

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The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4

Published: Sept. 6, 2023

The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation microglia and macrophages. Traditional classifications macrophage phenotypes include pro-inflammatory M1 anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed microglia-induced neuroinflammation. Different nutraceuticals focus on M1/M2 macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6'-disinapoylsucrose, resveratrol reduced microglial inflammatory markers while increased indicators in Alzheimer's disease. Amyloid beta-induced activation was suppressed andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, novel plant extracts also prevented microglia-mediated necroptosis apoptosis. Asarone, galangin, baicalein, a-mangostin oxidative stress cytokines, such as interleukin (IL)-1, IL-6, tumor necrosis factor-alpha M1-activated Parkinson's Additionally, myrcene, icariin, tenuigenin nod-like receptor family pyrin domain-containing 3 inflammasome neurotoxicity, a-cyperone, citronellol, nobiletin, taurine NADPH oxidase 2 nuclear factor kappa B activation. Furthermore, other like plantamajoside, swertiamarin, urolithin kurarinone, Daphne genkwa flower, Boswellia serrata showed promising neuroprotection treating In Huntington's disease, elderberry, iresine celosia, Schisandra chinensis, gintonin, pomiferin results improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, baicalein protected activated macrophages experimental autoimmune encephalomyelitis multiple sclerosis. emodin, esters gallic rosmarinic acids, Agathisflavone, sinomenine offered sclerosis treatments. This review highlights therapeutic potential using to treat diseases involving microglial-related pathways.

Language: Английский

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Screening of H2S donors with a red emission mitochondria-targetable fluorescent probe: Toward discovering a new therapeutic strategy for Parkinson's disease

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115521 - 115521

Published: July 6, 2023

Language: Английский

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Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 211, P. 111800 - 111800

Published: March 22, 2023

Language: Английский

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New Insights into Mechanisms Traditional Chinese Medicine for Allergic Rhinitis by Regulating Inflammatory and Oxidative Stress Pathways

Journal of Asthma and Allergy, Journal Year: 2024, Volume and Issue: Volume 17, P. 97 - 112

Published: Feb. 1, 2024

Abstract: Allergy rhinitis (AR) is becoming more common and has serious medical societal consequences. Sneezing, paroxysmal nasal blockage, itching, mucosal edema, coughing, rhinorrhea are symptoms of this type I allergic immunological illness. Immunoglobulin E-mediated inflammation the cause it. Because AR prone to recurrent attacks, extended medication therapy may impair its effectiveness. In addition negatively affecting patients' physical health, can also impact their mental health. During development, there inflammatory oxidative stress responses that linked problems in a number signal transduction pathways. By using terms "allergic rhinitis", "traditional Chinese medicine", "inflammation", "oxidative stress", we screened for pertinent research published over previous five years databases like PubMed. We saw NF-KB, TLR, IL-33/ST2, PI3K/AKT, MAPK, Nrf2 some most important pathways AR. Studies have revealed antioxidant anti-inflammatory reduced risk was therapeutic; however, varies widely. The system places high value on traditional medicine (TCM), which been virtually all China's 5000-year history. influencing signaling related stress, herbal constituent compounds shown prevent rhinitis. This review will focus evidence provide references clinical treatment scientific applications. Keywords: rhinitis, medicine, inflammatory,

Language: Английский

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