Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches DOI Creative Commons
Ayomide Victor Atoki, Patrick Maduabuchi Aja, Erick Nyakundi Ondari

et al.

International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(1), P. 2091 - 2127

Published: Aug. 3, 2023

The most rampant and complex form of dementia is Alzheimer's disease (AD) which characterized by various cognitive deficits personality abnormalities. AD a neurodegenerative condition marked the buildup beta-amyloid peptide fragments Tau protein in tangles brain neurons. presence β-amyloid peptide, protein, oxidative stress, an aggravated neuro-inflammatory response are all part its pathophysiological pathway. Quite number invertebrates have been genetically modified such that they express human proteins play role or two pathogenesis AD. Also, order to create animal model AD, quite substances investigated for their potential cause dysfunctions. following keywords were used search retrieve articles from reputable databases, including Scopus, Science Direct, Google Scholar PubMed: "Alzheimer's Disease," "Tau protein," "beta-secretase," "Cognitive Impairments," "Amyloid beta," "phytochemicals AD," "neurofibrillary tangles" "Neurotoxins induce aim this review advance better understanding functions roles amyloid precursor AD; offer updated recent information on use plant chemicals treatment It expedient state not biochemical, cognitive, behavioral histological disorders recapitulable. Nevertheless, research into etiology severely debilitating being aided experimental models created bioengineered organisms.

Language: Английский

Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications DOI Creative Commons

Shumaila Ijaz,

Javed Iqbal, Banzeer Ahsan Abbasi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

Citations

66
Exploring TNFR1: from discovery to targeted therapy development DOI Creative Commons
Yingying Li,

Ruiwei Ye,

Haorui Dai

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 15, 2025

Language: Английский

Citations

3
IL-2/anti-IL-2 complexes attenuates neuroinflammation and neurodegeneration in mice of experimental Parkinson's disease. DOI Creative Commons
Lanxin Li, Weiwei Gao,

Ning Ren

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111273 - 111273

Published: Feb. 1, 2025

Language: Английский

Citations

2
Recent advances in the therapeutic potential of emodin for human health DOI Open Access
Javad Sharifi‐Rad, Jesús Herrera‐Bravo, Senem Kamiloğlu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113555 - 113555

Published: Aug. 23, 2022

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with physiological role protection against abiotic stress vegetative tissues. used traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, damp-heat jaundice. Pharmacological research last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant anti-inflammatory. The study aimed summarize recent studies on bioavailability, preclinical pharmacological effects evidence molecular mechanisms, clinical trials pitfalls, respectively limitations emodin. For this purpose, extensive searches were performed using PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley SciFinder databases search engines. vitro vivo included updated review highlighted signaling pathways mechanisms Because its bioavailability low, there are use. In conclusion, for an increase pharmacotherapeutic efficacy, future carrier molecules target, thus opening up new perspectives.

Language: Английский

Citations

59
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation DOI Open Access
Javad Sharifi‐Rad, Simona Rapposelli, Simona Sestito

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1515 - 1515

Published: Sept. 15, 2022

Alzheimer's disease (AD) is a neurodegenerative characterized by tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence Aβ-amyloid peptide, protein, oxidative stress, an exacerbated neuro-inflammatory response. This review aims to offer updated compendium most recent promising advances AD treatment through administration phytochemicals. literature survey was carried out electronic search following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, Web Science regarding published works that included molecular mechanisms signaling pathways targeted phytochemicals various experimental models vitro vivo. results studies showed use against has gained relevance due their antioxidant, anti-neuroinflammatory, anti-amyloid, anti-hyperphosphorylation properties protein. Some bioactive compounds from plants have been shown ability prevent stop progression Alzheimer's.

Language: Английский

Citations

50
Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles DOI Creative Commons
Javad Sharifi‐Rad, Jesús Herrera‐Bravo, Prabhakar Semwal

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Sept. 5, 2022

plants are traditional and ethnopharmacologically used to treat several diseases in addition food, spices, beverages. The genus is widely distributed all continents except the Antarctica, medicine has been as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, antiviral agents. This review aimed at systematizing scientific data on geographical distribution, chemical composition, pharmacological toxicological profiles of

Language: Английский

Citations

48
TNF receptors: Structure-function relationships and therapeutic targeting strategies DOI
Chih Hung Lo

Biochimica et Biophysica Acta (BBA) - Biomembranes, Journal Year: 2024, Volume and Issue: unknown, P. 184394 - 184394

Published: Oct. 1, 2024

Language: Английский

Citations

9
Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity DOI Open Access
Georgia Xiromerisiou, Chrysoula Marogianni, Ioannis C. Lampropoulos

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 264 - 264

Published: Dec. 23, 2022

One of the major mediators neuroinflammation in PD is tumour necrosis factor alpha (TNF-α), which, similar to other cytokines, produced by activated microglia and astrocytes. Although TNF-α can be neuroprotective brain, long-term TNF release harmful, having a neurotoxic role that leads death oligodendrocytes, astrocytes, neurons and, therefore, associated with neurodegeneration. Apart from wide family molecules homologous structures, namely chemokines, play key neuro-inflammation drawing cytotoxic T-lymphocytes activating microglia. The objective current study was examine levels serum CCL2 (Chemokine (C-C motif) ligand 2), also known as MCP-1 (Monocyte Chemoattractant Protein-1), patients compared healthy controls. We investigated associations between these two inflammatory number clinical symptoms, particular, disease severity cognition. Such an assessment may point their prognostic value provide some treatment hints. advanced stage on Hoehn-Yahr scale showed increase stages 1 2 (p = 0.01). Additionally, UPDRS score significantly levels. levels, however, no significant associations.

Language: Английский

Citations

32
Natural essential oils as a new therapeutic tool in colorectal cancer DOI Creative Commons
Stefania Garzoli, Pedro Alarcón, G. A. Seitimova

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 13, 2022

Colorectal cancer (CRC) is the third most revalent type of in world and second common cause death (about 1 million per year). Historically, natural compounds their structural analogues have contributed to development new drugs useful treatment various diseases, including cancer. Essential oils are odorous products made up a complex mixture low molecular weight with recognized biological pharmacological properties investigated also for prevention The aim this paper highlight possible role essential CRC, composition preclinical studies involving them. It has been reviewed determine experimental models used anticancer potential mechanisms action CRC. Searches were performed following databases PubMed/Medline, Web science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. results analyzed showed that EOs exhibited wide range bioactive effects like cytotoxicity, antiproliferative, antimetastatic on cells through action. This updated review provides better quality scientific evidence efficacy as chemotherapeutic/chemopreventive agents Future translational clinical needed establish effective dose humans well suitable route administration maximum bioavailability efficacy. Given positive obtained from studies, can be considered efficient complementary therapies chemotherapy

Language: Английский

Citations

23
A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives DOI Creative Commons
Nida Zahra, Javed Iqbal, Muhammad Arif

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: March 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Language: Английский

Citations

14