Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Oct. 5, 2023

Accumulating evidence supports that physical exercise (EX) is the most effective non-pharmacological strategy to improve brain health. EX prevents cognitive decline associated with age and decreases risk of developing neurodegenerative diseases psychiatric disorders. These positive effects can be attributed an increase in neurogenesis neuroplastic processes, leading learning memory improvement. At molecular level, there a solid consensus involve neurotrophin brain-derived neurotrophic factor (BDNF) as crucial molecule for on brain. However, even though incontestably leads beneficial processes through BDNF expression, cellular sources mechanisms underlying EX-induced cerebral overproduction are still being elucidated. In this context, present review offers summary different involved brain’s response EX, specific focus BDNF. It aims provide cohesive overview three main production: neuronal-dependent overexpression, elevation blood flow (hemodynamic hypothesis), exerkine signaling emanating from peripheral tissues (humoral response). By shedding light these intricate pathways, seeks contribute ongoing elucidation relationship between offering valuable insights into potential therapeutic implications health enhancement.

Language: Английский

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Maternal Treadmill Exercise and Zinc Supplementation Alleviate Prenatal Stress–Induced Cognitive Deficits and Restore Neurological Biomarkers in Offspring: A Study on Male Rats Aged 30 and 90 Days

Developmental Neurobiology, Journal Year: 2025, Volume and Issue: 85(2)

Published: April 1, 2025

ABSTRACT The detrimental effects of prenatal stress (PS) on offspring's neurological and behavioral outcomes are well documented. However, strategies to mitigate these underexplored. This study examines whether zinc supplementation treadmill exercise can modulate PS‐induced cognitive impairments neurobiological markers in young adult male rat offspring, leveraging the established neuroprotective potential both physical activity zinc. Pregnant rats were divided into five groups: control, stress, + exercise, zinc, with all except control group subjected restraint (gestational days 15–19). groups underwent forced whereas those received oral sulfate throughout pregnancy. At postnatal 30 90, function offspring was evaluated using Morris water maze (MWM) test, hippocampal gene expression levels caspase‐3, brain‐derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP) measured reverse transcription–polymerase chain reaction (RT‐PCR). PS impaired functions, increased caspase‐3 expression, decreased BDNF GFAP rats. Prenatal found deficits primarily through enhancing improved mainly reduced expression. combined effect not additive functions biomarkers. Physical may alleviate by modulating astrocytic factors, exert its inhibiting apoptosis via a BDNF‐dependent pathway. Further targeted research is necessary confirm relationships.

Language: Английский

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BDNF and KISS-1 Levels in Maternal Serum, Umbilical Cord, and Placenta: The Potential Role of Maternal Levels as Effect Biomarker

Exposure and Health, Journal Year: 2023, Volume and Issue: 16(2), P. 445 - 461

Published: May 29, 2023

Abstract Brain-derived neurotrophic factor (BDNF) and kisspeptin-1 (KISS-1) regulate placental development fetal growth. The predictive value of maternal serum BDNF KISS-1 concentrations for umbilical cord levels has not yet been explored. influence prenatal lead (Pb) cadmium (Cd) exposure iron status on is also unclarified concern. In a pilot cross-sectional study with 65 mother–newborn pairs, we analyzed pro-BDNF, mature BDNF, KISS-1, gene expression in placenta, Pb Cd blood (erythrocytes), placenta. We conducted series vitro experiments using human primary trophoblast cells (hTCs) BeWo to verify main findings the epidemiological analysis. Strong consistent correlations were observed between corresponding tissue. Maternal red cell inversely correlated levels. Lower release was Pb-exposed cells. reduced cellular Cd-treated showed increased pro-BDNF Low positively associated low Iron-deficient hTCs decrease BDNF. levels, expression, respectively, indicate strong potential as matrix placentas sera. modulate but clear direction modulations evident. associations need be confirmed larger sample validated terms neurodevelopmental function.

Language: Английский

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Influence of a concurrent exercise training program during pregnancy on the placenta mitochondrial DNA integrity and content of minerals with enzymatic relevance. The GESTAFIT project

Placenta, Journal Year: 2023, Volume and Issue: 139, P. 19 - 24

Published: June 1, 2023

Language: Английский

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Resistance exercise was safe for the pregnancy and offspring’s development and partially protected rats against early life stress-induced effects

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 445, P. 114362 - 114362

Published: March 7, 2023

Language: Английский

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Oxytocin: A developmental journey

Comprehensive Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 16, P. 100203 - 100203

Published: Aug. 18, 2023

The neuropeptide hormone oxytocin is involved in many processes our bodies, linking social lives to internal states. I started out my career studying primate families, an interest that expanded into the role of family-oriented behaviors such as pair bonding and parenting prairie voles, humans, other primates. Starting a post-doc with Dr. C. Sue Carter, also became interested during development way we manipulate clinically. During then faculty member at University California, Davis, have worked on number these questions.

Language: Английский

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Severe maternal stress alters placental function, resulting in adipose tissue and liver dysfunction in offspring of mice

Molecular and Cellular Endocrinology, Journal Year: 2022, Volume and Issue: 560, P. 111814 - 111814

Published: Nov. 7, 2022

Language: Английский

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Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross‐Species Systematic Review

Developmental Psychobiology, Journal Year: 2024, Volume and Issue: 67(1)

Published: Dec. 5, 2024

ABSTRACT The prenatal period is a critical developmental juncture with enduring effects on offspring health trajectories. An individual's gut microbiome associated and outcomes across the lifespan. Prenatal stress can disrupt an infant's microbiome, thereby increasing susceptibility to adverse outcomes. This cross‐species systematic review investigates whether maternal affects offspring's microbiome. study analyzes 19 empirical, peer‐reviewed research articles, including humans, rodents, non‐human primates, that included as primary independent variable characteristics outcome variable. appeared correlate differences in beta diversity specific microbial taxa, but not alpha diversity. positively correlated Proteobacteria, Bacteroidaceae, Lachnospiraceae, Prevotellaceae, Bacteroides , Serratia . Negative correlations were observed for Actinobacteria, Enterobacteriaceae, Streptococcaceae, Bifidobacteria, Eggerthella, Parabacteroides Streptococcus Evidence direction of association between Lactobacillus was mixed. synthesis findings limited by design, operationalization timing stress, infant sampling, analysis methods.

Language: Английский

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A “toxic window” study on the hippocampal development of mice offspring exposed to azithromycin at different doses, courses, and time during pregnancy

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 387, P. 110814 - 110814

Published: Nov. 21, 2023

Language: Английский

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