MicroRNA‐140‐5p inhibitor attenuates memory impairment induced by amyloid‐ß oligomer in vivo possibly through Pin1 regulation DOI
Pariya Khodabakhsh, Maryam Bazrgar, Fatemeh Mohagheghi

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2022, Volume and Issue: 29(1), P. 91 - 103

Published: Oct. 2, 2022

Abstract Aims The peptidyl‐prolyl cis/trans isomerase, Pin1, has a protective role in age‐related neurodegeneration by targeting different phosphorylation sites of tau and the key proteins required to produce Amyloid‐β, which are well‐known molecular signatures Alzheimer's disease (AD) neuropathology. direct interaction miR‐140‐5p with Pin1 mRNA its inhibitory protein translation been identified. main purpose this study was investigate miRNA‐140‐5p inhibition promoting expression therapeutic potential AntimiR‐140‐5p Aß oligomer (AßO)‐induced AD rat model. Methods Spatial learning memory were assessed Morris water maze. RT‐PCR, western blot, histological assays performed on hippocampal samples at various time points after treatments. enhanced ADAM10 expressions but little effect level. Results inhibitor markedly ameliorated spatial deficits induced AßO, concomitantly suppressed inflammatory mediators TNFα IL‐1β, three (thr231, ser396, ser404) as well increased phosphorylated Ser473‐Akt. Conclusion According our results, Antimir‐140‐mediated improvement AβO‐induced neuronal injury impairment rats may provide an appropriate rationale for evaluating inhibitors promising agent treatment AD.

Language: Английский

Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria DOI
Prashanth Gowda, P. Hemachandra Reddy, Subodh Kumar

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 73, P. 101529 - 101529

Published: Nov. 20, 2021

Language: Английский

Citations

107
Mitochondrial microRNAs: Key Drivers in Unraveling Neurodegenerative Diseases DOI Open Access
Raya Kh. Yashooa, Elisa Duranti, Donatella Conconi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 626 - 626

Published: Jan. 13, 2025

MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) crucial for regulating gene expression at the post-transcriptional level. Recent evidence has shown that miRNAs also found in mitochondria, organelles produce energy cell. These mitochondrial miRNAs, known as mitomiRs, essential function and metabolism. MitomiRs can originate from nucleus, following traditional miRNA biogenesis pathways, or potentially DNA, allowing them to directly affect cellular dynamics within mitochondrion. While have been extensively investigated, involvement mitomiRs development neurodegenerative disorders like Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis remain be elucidated. This review aims discuss findings on role such diseases their potential therapeutic targets, well highlight future research directions.

Language: Английский

Citations

2
Autophagy and apoptosis cascade: which is more prominent in neuronal death? DOI

Rohan Gupta,

Rashmi K. Ambasta, Pravir Kumar

et al.

Cellular and Molecular Life Sciences, Journal Year: 2021, Volume and Issue: 78(24), P. 8001 - 8047

Published: Nov. 6, 2021

Language: Английский

Citations

103
MicroRNA Dysregulation in Parkinson’s Disease: A Narrative Review DOI Creative Commons
Yong Hui Nies,

Nor Haliza Mohamad Najib,

Wei Ling Lim

et al.

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: April 30, 2021

Parkinson’s disease (PD) is a severely debilitating neurodegenerative disease, affecting the motor system, leading to resting tremor, cogwheel rigidity, bradykinesia, walking and gait difficulties, postural instability. The severe loss of dopaminergic neurons in substantia nigra pars compacta causes striatal dopamine deficiency presence Lewy bodies indicates pathological hallmark PD. Although current treatment PD aims preserve or replace depletion brain, it notable that complete recovery from yet be achieved. Given complexity multisystem effects PD, underlying mechanisms pathogenesis are elucidated. advancement medical technologies has given some insights understanding mechanism potential with special interest role microRNAs (miRNAs) unravel pathophysiology In patients, was found brain tissue demonstrated dysregulated miRNAs expression profiles. Hence, dysregulation may contribute through modulation PD-associated gene protein expression. This review will discuss recent findings on dysregulation, regulation genes, neuron survival, α-synuclein-induced inflammation circulating miRNAs. next section this also provides an update uses as diagnostic biomarkers therapeutic tools for

Language: Английский

Citations

77
MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases DOI Open Access
T. P. Nhung Nguyen, Mandeep Kumar, Ernesto Fedele

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4718 - 4718

Published: April 25, 2022

MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions play a key role pathological conditions. Numerous studies have demonstrated that miRNAs dysregulated major neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s multiple sclerosis, amyotrophic lateral or Huntington’s disease. Hence, the present work, we constructed comprehensive overview of individual microRNA alterations models above diseases. We also provided evidence promising biomarkers for prognostic diagnostic approaches. In addition, summarized data from literature about miRNA-based therapeutic applications via inhibiting promoting miRNA expression. finally identified overlapping signature across including miR-128, miR-140-5p, miR-206, miR-326, miR-155, associated with etiological cellular mechanisms. However, it remains to be established whether what extent therapies could safely exploited future effective symptomatic disease-modifying approaches different human disorders.

Language: Английский

Citations

53
The role of mitochondrial dysfunction in Alzheimer's disease: A potential pathway to treatment DOI
Allison B. Reiss,

Saba Ahmed,

Christopher Dayaramani

et al.

Experimental Gerontology, Journal Year: 2022, Volume and Issue: 164, P. 111828 - 111828

Published: May 1, 2022

Language: Английский

Citations

39
miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease DOI Creative Commons
Sang‐Won Han, Jung‐Min Pyun, Paula J. Bice

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 9, 2024

Abstract Background Alzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology prognostic/diagnostic biomarkers. Methods We performed co-expression to identify modules associated with AD, its neuropathology markers, cognition using brain tissue profiles from the Religious Orders Study Rush Memory Aging Project (ROS/MAP) ( N = 702) as a discovery dataset. association hub miRNAs cognition. After selecting target genes miRNAs, we their then pathway-based enrichment analysis. For replication, consensus ROS/MAP dataset an independent 16) Gene Expression Omnibus (GEO). Furthermore, approach assess performance for classification. Results Network identified glucose metabolism pathway-enriched module (M3) significantly Five (miR-129-5p, miR-433, miR-1260, miR-200a, miR-221) M3 had significant associations clinical and/or pathologic traits, miR129-5p by far strongest across all phenotypes. Gene-set corresponding enriched biological pathways ErbB, AMPK, MAPK, mTOR signaling pathways. Consensus two AD-associated (miR-129-5p miR-221). Machine showed that classification (area under curve (AUC) 0.807) age, sex, APOE ε4 carrier status was improved 6.3% inclusion five miRNAs. Conclusions signatures, especially miR-129-5p, cognition, enhancing our understanding leading better potential diagnostic/prognostic

Language: Английский

Citations

12
Exosomes and non-coding RNAs: bridging the gap in Alzheimer’s pathogenesis and therapeutics DOI Creative Commons

Chunhui Guo,

You Yanqiu,

Jibing Chen

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 4, 2025

Alzheimer's disease (AD) is a neurodegenerative that primarily affects the elderly population and leading cause of dementia. Meanwhile, vascular hypothesis suggests damage occurs in early stages disease, to neurodegeneration hindered waste clearance, which turn triggers series events including accumulation amyloid plaques Tau protein tangles. Non-coding RNAs (ncRNAs), long noncoding (lncRNAs), microRNAs (miRNAs), circular (circRNAs), have been found be involved regulation AD. Furthermore, lncRNAs circRNAs can act as competitive endogenous inhibit miRNAs, their interactions form complex regulatory network. Exosomes, are extracellular vesicles (EVs), believed able transfer ncRNAs between cells, thus playing role brain by crossing blood-brain barrier (BBB). Exosomes part intercellular carrier system; therefore, utilizing exosomes deliver drugs recipient cells might not activate immune system, making it potential strategy treat central nervous system diseases. In this review, we review AD multifactorial neurological regulate its multiple pathogenic mechanisms improve our understanding etiology simultaneously through binding treatment

Language: Английский

Citations

1
Synaptosome microRNAs regulate synapse functions in Alzheimer’s disease DOI Creative Commons
Subodh Kumar,

Erika Orlov,

Prashanth Gowda

et al.

npj Genomic Medicine, Journal Year: 2022, Volume and Issue: 7(1)

Published: Aug. 8, 2022

MicroRNAs (miRNAs) are found in nerve terminals, synaptic vesicles, and synaptosomes, but it is unclear whether cytosolic miRNA populations differ Alzheimer's disease (AD) or if synaptosomal miRNAs affect AD synapse activity. To address these questions, we generated synaptosomes fractions from postmortem brains of unaffected control (UC) samples analyzed them using a global Affymetrix microarray platform. A group significantly differed (P < 0.0001) with high fold changes variance (+/- >200-fold) their expressions different comparisons: (1) UC synaptosome vs cytosol, (2) (3) cytosol (4) synaptosomes. MiRNAs data analysis revealed that some potential were consistently across sample groups. These differentially expressed further validated brains, APP transgenic (Tg2576), Tau (P301L), wild-type mice. The miR-501-3p, miR-502-3p, miR-877-5p identified as upregulated progression based on Braak stages. Gene Ontology Enrichment Ingenuity Pathway Analysis showed the involvement nervous system development, cell junction organization, assembly formation, function GABAergic synapse. This first description versus significance function.

Language: Английский

Citations

30
MicroRNAs regulation in Parkinson’s disease, and their potential role as diagnostic and therapeutic targets DOI Creative Commons
Nour Shaheen,

Ahmed Shaheen,

Mahmoud Osama

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 5, 2024

Language: Английский

Citations

8