Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 213, P. 111838 - 111838

Published: June 15, 2023

Language: Английский

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Unlocking the Therapeutic Promise of miRNAs in Promoting Amyloid-β Clearance for Alzheimer's Disease.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115505 - 115505

Published: Feb. 1, 2025

Language: Английский

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Critical role of microRNAs in cellular quality control during brain aging and neurological disorders: Interplay between autophagy and proteostasis

Life Sciences, Journal Year: 2025, Volume and Issue: 369, P. 123563 - 123563

Published: March 13, 2025

A decline in cellular quality control mechanisms is one of the processes brain aging. Autophagy and proteostasis are two regulatory that maintain component turnover to preserve homeostasis, optimal function, neuronal health by eliminating damaged aggregated proteins preventing neurodegenerative disorders (NDDs). Impaired autophagy significant hallmarks aging many age-related NDDs. MicroRNAs noncoding RNA molecules have recently been shown be essential for regulating several biological processes, such as autophagy, proteostasis, differentiation, development targeting mRNA's 3'untranslated region (3'UTR). During aging, miRNAs dysregulate resulting abnormal activity protein aggregation, a characteristic This review highlights complex interactions orchestration autophagy. dysregulation impairs autophagic flux accelerates disorders, neuroinflammation, neurodegeneration. Understanding among miRNAs, novel therapeutics

Language: Английский

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Autophagy: a double-edged sword in ischemia–reperfusion injury

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Abstract Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon restoration of flow (reperfusion). This phenomenon can lead to irreversible damage and commonly observed in contexts such as cardiac surgery stroke, where temporarily obstructed. During ischemic conditions, anaerobic metabolism tissues organs results compromised enzyme activity. Subsequent reperfusion exacerbates mitochondrial dysfunction, leading increased oxidative stress accumulation reactive oxygen species (ROS). cascade ultimately triggers cell death through mechanisms autophagy mitophagy. Autophagy constitutes a crucial catabolic mechanism within eukaryotic cells, facilitating degradation recycling damaged, aged, or superfluous organelles proteins via lysosomal pathway. essential for maintaining cellular homeostasis adapting diverse conditions. As self-degradation clearance mechanism, exhibits dualistic function: it confer protection during initial phases injury, yet potentially exacerbate later stages. paper aims elucidate fundamental I/R highlighting its dual role regulation effects on both organ-specific systemic responses. By comprehending their implications organ function, this study seeks explore potential therapeutic interventions modulation clinical settings.

Language: Английский

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The emerging role of miRNAs in biological aging and age-related diseases

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Genomic ncRNAs Regulating Mitochondrial Function in Neurodegeneration: A Neglected Clue in the Complex Etiopathogenesis of Multiple Sclerosis

Published: May 7, 2025

Multiple sclerosis (MS), the most prevalent myelinopathy with unclear etiology, involves mitochondrial dysfunction that critically contributes to oligodendrocyte damage and neurodegeneration. Recent interest has surged around role of inflammatory ncRNAs in function, particularly context neurodegenerative diseases (NDs) where neuroinflammationis a hallmark feature. This review emphasizes collection characterization mitochondrial-related (MR) non-coding RNAs (ncRNAs) (MRncRNAs), have been extensively studied NDs. Through literature review, we identified 36 upregulated MRncRNAs Parkinson's disease (PD), Amyotrophic lateral (ALS), Alzheimer's (ALZ), Huntington's (HD). Notably, miR-34 was most dominantly dysregulated miR PD, ALS, ALZ while HD, two other miRNAs (miR-10b-5p miR-196a) identified. Further bioinformatic analysis revealed miR-124-5p, -146a-3p, -15b-3p target genes more than others, mRNA pro-apoptotic protein BCL2L11 is targeted. link between these function MS remains unidentified. Among 81 detected patients, nine (miR-15b, miR-21, miR-27b, miR-34a, miR-124, miR-137, miR-146a, miR-155, miR-92a) shared lncRNAs (MALAT1 HOTAIR). autophagy pathway involved. Six are significantly involved MR diseases. miR-34a-5p showed connection mitochondria, miR-15b targeted hub genes, SDHC BCL2. Moreover, several proteins (HIF1A, STAT3, MAPK1, GSK3B) by well-known regulators pathways homeostasis: These findings highlight critical roles neurodegeneration, emphasizing urgent need for experimental studies on MRmiRNAs, myelinopathies.

Language: Английский

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Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: May 7, 2025

Alzheimer’s disease (AD) is a neurodegenerative condition associated with aging. As the population ages, incidence of AD has risen annually, making it fourth leading cause death, following cardiovascular disease, cancer, and stroke. The main pathological features are now thought to include accumulation extracellular amyloid-β (Aβ) plaques, formation intracellular neurofibrillary tangles, reduction in synaptic connections cerebral cortex hippocampus. Polyphenols help protect against by influencing Aβ metabolism. Research shown that polyphenols particularly effective reducing inflammation inhibiting tumor necrosis factor-activated TNF-κB activity, indicating their significant pharmacological activity. MicroRNAs (miRNAs) play role regulating miRNA stability protein expression after transcription. They prevalent brain tissue can specifically influence neuronal growth synapses. levels miRNAs brains patients significantly differ from those healthy individuals same age. have been recognized as potential biological markers therapeutic targets for early diagnosis AD. It important note gene regulation affecting various miRNAs, suggesting link between polyphenols, AD, miRNAs. This review examines whether impact APP Aβ. Additionally, we explored effects on related

Language: Английский

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miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: May 13, 2025

MicroRNAs (miRNAs) are small non-coding RNA molecules that known to regulate gene expression in their target locations thereby contributing epigenetic mechanisms associated with disease pathologies. Dysregulation of miRNA activity has been implicated the pathology Alzheimer’s (AD), offering insights into potential biomarkers for early diagnosis and therapeutic targets. Mitochondrial dysfunction its effects (such as oxidative stress) can be seen early-onset AD. This review critically examines recent findings on mitochondrial-associated miRNAs—including miR-34a, miR-140, miR-455-3p, miR-1273g-3p—highlighting roles mitochondrial bioenergetics, stress, synaptic function. We discuss targeting specific miRNAs restore health explore utility AD diagnosis. A better understanding miRNA-mediated regulation may open new avenues intervention

Language: Английский

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PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 4, 2022

As a primary cause of dementia and death in older people, Alzheimer's disease (AD) has become common problem challenge worldwide. Abnormal accumulation tau proteins the brain is hallmark pathology AD closely related to clinical progression severity cognitive deficits. Here, we found that overexpression phosphatase tensin homolog (PTEN)-induced kinase 1 (PINK1) effectively promoted degradation tau, thereby rescuing neuron loss, synaptic damage, impairments mouse model tauopathy with AAV-full-length human Tau (hTau) injected into hippocampal CA1 area (hTau mice). Overexpression PINK1 activated autophagy, chloroquine but not MG132 reversed PINK1-induced decrease levels improvement hTau mice. Furthermore, also ameliorated mitochondrial dysfunction induced by hTau. Taken together, our data revealed abnormal accumulated via autophagy-lysosome pathway, indicating may be potential target for treatment.

Language: Английский

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The Potential Role of miRNA-Regulated Autophagy in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7789 - 7789

Published: July 14, 2022

As a neurodegenerative disease, Alzheimer’s disease (AD) shows higher incidence during the aging process, mainly revealing characteristics of significant decrease in cognition, uncontrolled emotion, and reduced learning memory capacity, even leading to death. In prevention treatment AD, some pharmacological therapy has been applied clinical practice. Unfortunately, there are still limited effective treatments for AD due absence clear defined targets. Currently, it is recognized that causes include amyloid-β peptide (Aβ) deposition, hyperphosphorylation tau protein, neurofibrillary tangles, mitochondrial dysfunction, inflammation. With in-depth mechanistic exploration, found these highly correlated with dysfunctional status autophagy. Numerous experimental results have also confirmed development progression accompanied by an abnormal functional autophagy; therefore, regulating autophagy become one important strategies alleviating or arresting AD. increasing attention given microRNAs (miRNAs), more studies series miRNAs involved through indirect regulation Therefore, targeting may be essential breakthrough This article summarizes autophagy, aim providing new theoretical reference point miRNA-mediated

Language: Английский

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