Mitochondrial microRNAs: Key Drivers in Unraveling Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 626 - 626

Published: Jan. 13, 2025

MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) crucial for regulating gene expression at the post-transcriptional level. Recent evidence has shown that miRNAs also found in mitochondria, organelles produce energy cell. These mitochondrial miRNAs, known as mitomiRs, essential function and metabolism. MitomiRs can originate from nucleus, following traditional miRNA biogenesis pathways, or potentially DNA, allowing them to directly affect cellular dynamics within mitochondrion. While have been extensively investigated, involvement mitomiRs development neurodegenerative disorders like Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis remain be elucidated. This review aims discuss findings on role such diseases their potential therapeutic targets, well highlight future research directions.

Language: Английский

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Peri-centrosomal localization of small interfering RNAs in C. elegans

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

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Regulatory roles of microRNAs in modulating mitochondrial dynamics, amyloid beta fibrillation, microglial activation, and cholinergic signaling: Implications for alzheimer's disease pathogenesis

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105685 - 105685

Published: April 25, 2024

Language: Английский

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Mitochondrial Extracellular Vesicles (mitoEVs): emerging mediators of cell-to-cell communication in health, aging and age-related diseases.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102522 - 102522

Published: Oct. 1, 2024

Language: Английский

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Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Genomic ncRNAs Regulating Mitochondrial Function in Neurodegeneration: A Neglected Clue in the Complex Etiopathogenesis of Multiple Sclerosis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Multiple sclerosis (MS), the most prevalent myelinopathy with unclear etiology, involves mitochondrial dysfunction that critically contributes to oligodendrocyte damage and neurodegeneration. Recent interest has surged around role of inflammatory ncRNAs in function, particularly context neurodegenerative diseases (NDs) where neuroinflammationis a hallmark feature. This review emphasizes collection characterization mitochondrial-related (MR) non-coding RNAs (ncRNAs) (MRncRNAs), have been extensively studied NDs. Through literature review, we identified 36 upregulated MRncRNAs Parkinson's disease (PD), Amyotrophic lateral (ALS), Alzheimer's (ALZ), Huntington's (HD). Notably, miR-34 was most dominantly dysregulated miR PD, ALS, ALZ while HD, two other miRNAs (miR-10b-5p miR-196a) identified. Further bioinformatic analysis revealed miR-124-5p, -146a-3p, -15b-3p target genes more than others, mRNA pro-apoptotic protein BCL2L11 is targeted. link between these function MS remains unidentified. Among 81 detected patients, nine (miR-15b, miR-21, miR-27b, miR-34a, miR-124, miR-137, miR-146a, miR-155, miR-92a) shared lncRNAs (MALAT1 HOTAIR). autophagy pathway involved. Six are significantly involved MR diseases. miR-34a-5p showed connection mitochondria, miR-15b targeted hub genes, SDHC BCL2. Moreover, several proteins (HIF1A, STAT3, MAPK1, GSK3B) by well-known regulators pathways homeostasis: These findings highlight critical roles neurodegeneration, emphasizing urgent need for experimental studies on MRmiRNAs, myelinopathies.

Language: Английский

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Peri-centrosomal localization of small interfering RNAs in C. elegans

Published: July 12, 2024

Abstract The centrosome is the microtubule-organizing center and a crucial part of cell division. Centrosomal RNAs (cnRNAs) have been reported to enable precise spatiotemporal control gene expression during division in many species. Whether how cnRNAs exist C. elegans are unclear. Here, using nuclear RNAi Argonaute protein NRDE-3 as reporter, we observed potential peri-centrosome localized small interfering (si)RNAs . was previously shown associate with pre-mRNAs pre-rRNAs via process involving presence complementary siRNAs. We generated GFP-NRDE-3 knock-in transgene through CRISPR/Cas9 technology that formed peri-centrosomal foci neighboring tubulin TBB-2, other centriole proteins pericentriolar material (PCM) components embryos. accumulation depends on RNA-dependent RNA polymerase (RdRP)-synthesized 22G siRNAs PAZ domain NRDE-3, which essential for siRNA binding. Mutation eri-1, ergo-1 , or drh-3 significantly increased percentage pericentrosome-enriched NRDE-3. At metaphase cycle, enriched both region spindle. Moreover, integrity also required Therefore, concluded could accumulate suggested may be platform RNAi-mediated regulation.

Language: Английский

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The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(4)

Published: Oct. 28, 2024

Language: Английский

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Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi

Current Oncology, Journal Year: 2024, Volume and Issue: 31(5), P. 2881 - 2894

Published: May 17, 2024

This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 2022, this descriptive, quantitative observational research analyzed 90 formalin-fixed paraffin-embedded (FFPE) samples from Pius Brinzeu County Emergency Clinical Hospital, Timisoara, including 45 advanced-stage melanoma pigmented nevi. purification analysis were performed using miRNeasy Kit Human Cancer PathwayFinder miScript PCR Array, statistical (including logistic regression) determine associations cancer staging, such high Breslow index risk, number mitoses, vascular invasion. After comparison 180 subtypes, we selected 10 most upregulated downregulated genes. The results revealed hsa-miR-133b, hsa-miR-335-5p, hsa-miR-200a-3p, hsa-miR-885-5p significantly samples, fold changes ranging 1.09 1.12. Conversely, hsa-miR-451a hsa-miR-29b-3p showed notable downregulation 0.90 0.92, respectively. Additionally, regression identified (OR = 2.51) hsa-miR-200a-3p 2.10) associated an increased risk a index, while hsa-miR-127-3p reduced risk. Conclusively, underscores alterations compared highlights potential specific miRNAs biomarkers identification characteristics suggests their utility developing non-invasive, cost-effective diagnostic tools guiding therapeutic decisions, potentially improving patient outcomes management.

Language: Английский

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Nörodejeneratif Hastalıklarda Yeni Bir Yaklaşım: Mitokondri Hedefli Tedavi

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Mitokondri hücrenin enerji metabolizmasında, oksidatif fosforilasyonda ve hücre ölümünde rol alan temel organeli olup pek çok hastalıkta olduğu gibi nörodejeneratif hastalıkların da patogenezine katkı sağlar. Günümüzde çoğu hastalığın etiyopatogenezinde reaktif oksijen nitrojen türlerine bağlı hasar sorumlu tutulmakla birlikte antioksidan tedaviler bu hasarın önlenmesi iyileştirilmesi konusunda yeterli olmamaktadır. Bu nedenle son yıllarda mitokondriyi direkt olarak hedefleyen içerisinde biriken farklı farmakolojik ajanlar geliştirilmiş birçok nörodejenerasyon hayvan modelinde iyileştirici etkileri görülmüştür. Aynı zamanda ajanlardan bazılarının insan klinik çalışmalarında güvenilir etkili kanıtlanmıştır. derlemede, Alzheimer Parkinson hastalıkları başta olmak üzere hastalıklarda mitokondri disfonksiyonu tedavisinde olacağı düşünülen hedefli tedavi ile ilgili güncel bilgiler tartışılmıştır.

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