Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence DOI Creative Commons

Samuel T. Vielee,

John Pierce Wise

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 500 - 500

Published: March 16, 2023

Advancements in modern medicine have improved the quality of life across globe and increased average lifespan our population by multiple decades. Current estimates predict 2030, 12% global will reach a geriatric age live another 3-4 This swelling place critical stress on healthcare infrastructures due to accompanying increases age-related diseases comorbidities. While much research focused long-lived individuals seeks answer questions regarding how healthier, there is deficit investigating what aspects lives accelerate or exacerbate aging. In particular, heavy metals are recognized as significant threat human health with links plethora diseases, widespread exposures from occupational, medical, environmental settings. We believe ought be classified class gerontogens (i.e., chemicals that biological aging cells tissues). Gerontogens may best studied through their effects "Hallmarks Aging", nine physiological hallmarks demonstrated occur aged cells, tissues, bodies. Evidence suggests cellular senescence-a permanent growth arrest cells-is one most pertinent useful indicator tissues. Here, we discuss roles brain briefly general, then expand upon observations for contributing neurodegenerative disorders. particularly emphasize senescence diseases. Finally, inducing senescence. The glaring lack knowledge about gerontogenic mechanisms necessitates greater field, especially context crisis.

Language: Английский

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration DOI Creative Commons
Sheryar Afzal, Aimi Syamima Abdul Manap, Ali Attiq

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Language: Английский

Citations

117
A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles DOI Creative Commons
Sergey V. Gudkov, Dmitriy E. Burmistrov, Veronika V. Smirnova

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(15), P. 2635 - 2635

Published: July 30, 2022

Bacterial antibiotic resistance is one of the most serious modern biomedical problems that prioritizes search for new agents to combat bacterial pathogens. It known nanoparticles many metals and metal oxides can have an antibacterial effect. However, efficacy aluminum oxide has been studied little compared well-known antimicrobial properties such as zinc, silver, iron, copper. In this review, we focused on experimental studies accumulated date demonstrating effect nanoparticles. The review discusses main ways synthesis modification these nanoparticles, provides proposed mechanisms their action against gram-positive gram-negative bacteria, also compares depending morphological characteristics. We partially considered activity water microalgae fungi. general, a more detailed study great interest due low toxicity eukaryotic cells.

Language: Английский

Citations

79
Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity DOI
Balachandar Vellingiri,

Atchaya Suriyanarayanan,

Priyanka Selvaraj

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 301, P. 134625 - 134625

Published: April 16, 2022

Language: Английский

Citations

74
Mechanisms of Cadmium Neurotoxicity DOI Open Access

Madelyn A. Arruebarrena,

Calvin T. Hawe, Young Min Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16558 - 16558

Published: Nov. 21, 2023

Cadmium is a heavy metal that increasingly contaminates food and drink products. Once ingested, cadmium exerts toxic effects pose significant threat to human health. The nervous system particularly vulnerable prolonged, low-dose exposure. This review article provides an overview of cadmium’s primary mechanisms neurotoxicity. gains entry into the via zinc calcium transporters, altering homeostasis for these ions. within system, disrupts mitochondrial respiration by decreasing ATP synthesis increasing production reactive oxygen species. also impairs normal neurotransmission neurotransmitter release asynchronicity disrupting signaling proteins. furthermore blood–brain barrier alters regulation glycogen metabolism. Together, represent multiple sites biochemical perturbation result in cumulative damage which can increase risk neurological neurodegenerative disorders. Understanding way its critical developing effective treatment prevention strategies against cadmium-induced neurotoxic insult.

Language: Английский

Citations

51
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions DOI Creative Commons

Stacey A. Sakowski,

Emily J. Koubek, Kevin S. Chen

et al.

Annals of Neurology, Journal Year: 2024, Volume and Issue: 95(4), P. 635 - 652

Published: Feb. 27, 2024

Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes multifactorial complex, evidence suggests dynamic interplay between genes the environment, emphasizing importance of identifying understanding role lifelong exposures, known as exposome, nervous system. This review provides an overview recent advances toward defining neurodegenerative disease exposomes, focusing Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease. We present current state field based emerging data, elaborate key themes potential mechanisms, conclude with limitations future directions. ANN NEUROL 2024;95:635-652.

Language: Английский

Citations

18
Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb,

Ali K. Albuhadily

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Parkinson's disease (PD) is a progressive neurodegenerative brain due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response the disturbance diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has neuroprotective effect against neuropathology by protecting DNs substantia nigra pars compacta (SNpc). It been shown that GABAergic linked progression neurotransmission necessary pathway for normal sleep patterns, thus deregulation could be potential cause disorders PD.

Language: Английский

Citations

18
Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders DOI Creative Commons
Olayemi K. Ijomone, Ukwubile Ileje Inelo, Vivian O. Aneke

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Language: Английский

Citations

3
Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives DOI Creative Commons
Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

Citations

2
A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions DOI Creative Commons

Evripides Iakovou,

Malamati Kourti

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: June 13, 2022

Aging is a normal, inevitable, irreversible, and progressive process which driven by internal external factors. Oxidative stress, that the imbalance between prooxidant antioxidant molecules favoring first, plays key role in pathophysiology of aging comprises one molecular mechanisms underlying age-related diseases. However, oxidative stress theory has not been successfully proven all animal models studying lifespan, meaning altering stress/antioxidant defense systems did always lead to prolonged as expected. On other hand, pathological phenotypes showed well-correlated relationship with levels molecules. Therefore, it seems more complicated than once believed this might be affected environment each organism. Environmental factors such UV radiation, air pollution, an unbalanced diet, have also implicated seem initiate rapidly even at younger ages.The purpose review elucidate physiology effect certain environmental initiating sustaining process. Understanding will contribute development strategies postpone phenomenon. In addition, recent studies investigating ways alter order prevent presented.Careful exposure harmful use supplements could potentially affect biological processes driving slow down Maybe lifespan achieved strategy alone, but longer healthspan favorable target.

Language: Английский

Citations

58
Environmental Impact on the Epigenetic Mechanisms Underlying Parkinson’s Disease Pathogenesis: A Narrative Review DOI Creative Commons
Efthalia Angelopoulou, Yam Nath Paudel, Sokratis G. Papageorgiou

et al.

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(2), P. 175 - 175

Published: Jan. 28, 2022

Parkinson's disease (PD) is the second most common neurodegenerative disorder with an unclear etiology and no disease-modifying treatment to date. PD considered a multifactorial disease, since both genetic environmental factors contribute its pathogenesis, although molecular mechanisms linking these two key modifiers remain obscure. In this context, epigenetic that alter gene expression without affecting DNA sequence through methylation, histone post-transcriptional modifications, non-coding RNAs may represent mediators of genetic-environmental interactions underlying pathogenesis. Environmental exposures cause chemical alterations in several cellular functions, including expression. Emerging evidence has highlighted smoking, coffee consumption, pesticide exposure, heavy metals (manganese, arsenic, lead, etc.) potentially affect risk development at least partially via modifications. Herein, we discuss recent accumulating pre-clinical clinical impact lifestyle on development, aiming shed more light pathogenesis stimulate future research.

Language: Английский

Citations

56