An Interpretable Deep Learning Optimized Wearable Daily Detection System for Parkinson’s Disease DOI Creative Commons
Min Chen,

Zhanfang Sun,

Xin Tao

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2023, Volume and Issue: 31, P. 3937 - 3946

Published: Jan. 1, 2023

Walking detection in the daily life of patients with Parkinson's disease (PD) is great significance for tracking progress disease. This study aims to implement an accurate, objective, and passive algorithm optimized based on interpretable deep learning architecture walking PD explore most representative spatiotemporal motor features. Five inertial measurement units attached wrist, ankle, waist are used collect motion data from 100 subjects during a 10-meter test. The raw each sensor subjected continuous wavelet transform train classification model constructed 6-channel convolutional neural network (CNN). results show that located at has best performance accuracy 98.01%±0.85% area under receiver operating characteristic curve (AUC) 0.9981±0.0017 ten-fold cross-validation. gradient-weighted class activation mapping shows feature points greater contribution were concentrated lower frequency band (0.5~3Hz) compared healthy controls. visual maps 3D CNN only three out six time series have contribution, which as basis further optimize input, greatly reducing processing costs (50%) while ensuring its (AUC=0.9929±0.0019). To our knowledge, this first consider interpretation-based optimization intelligent diagnosis PD.

Language: Английский

Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson’s disease DOI Open Access
Yasemin Açar, Duygu Ağagündüz, Paola De Cicco

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115788 - 115788

Published: Oct. 31, 2023

Parkinson's Disease (PD), a neurodegenerative disorder, is characterized by the degeneration of progressive dopaminergic (DA) neurons in substantia nigra region human midbrain. Although just what causes PD remains mystery, it known that oxidative stress (OS) as well mitochondrial dysfunction, neuro-inflammation, and insufficient neurotrophic support play role disease's pathophysiology. Phytochemicals are diverse small molecule group derived from plants can be classified into numerous classes on basis their biological activities chemical structure. Of these groups phytochemicals, most abundant, which has well-established anti-Parkinson's effects, polyphenols. Flavonoids, including naringin naringenin, genistein, kaempferol, anthocyanins, epigallocatechin-3-gallate, baicalein plant-based biologically active polyphenols, have been shown to exhibit therapeutic potential when used treatment for variety pathological illnesses, such diseases (NDs) PD. Recently, was reported flavonoids beneficial effects PD, protection DA neurons, improvement motor cognitive abilities, regulation signaling pathways, modulation OS neuro-inflammation. In addition, changing composition bacteria gut microbiota, reduce pathogenic strains promote growth strains. this context, current paper will provide literature review neurological roles play, one abundant phytochemical families,

Language: Английский

Citations

77
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions DOI Creative Commons

Stacey A. Sakowski,

Emily J. Koubek, Kevin S. Chen

et al.

Annals of Neurology, Journal Year: 2024, Volume and Issue: 95(4), P. 635 - 652

Published: Feb. 27, 2024

Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes multifactorial complex, evidence suggests dynamic interplay between genes the environment, emphasizing importance of identifying understanding role lifelong exposures, known as exposome, nervous system. This review provides an overview recent advances toward defining neurodegenerative disease exposomes, focusing Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease. We present current state field based emerging data, elaborate key themes potential mechanisms, conclude with limitations future directions. ANN NEUROL 2024;95:635-652.

Language: Английский

Citations

18
Epidemiology of Parkinson’s Disease: An Update DOI

Juan R. Deliz,

Caroline M. Tanner, Paulina Gonzàlez‐Latapi

et al.

Current Neurology and Neuroscience Reports, Journal Year: 2024, Volume and Issue: 24(6), P. 163 - 179

Published: April 20, 2024

Language: Английский

Citations

17
LINC02282 promotes DNA methylation of TRIM6 by recruiting DNMTs to inhibit the progression of Parkinson's disease DOI Creative Commons
Lu Han, Chuansheng Zhao,

Jin Feng

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111224 - 111224

Published: Jan. 1, 2025

Parkinson's disease (PD) is the second most common neurodegenerative disease. Long non-coding RNAs (lncRNAs) are closely linked to occurrence and development of diseases, while underlying mechanisms remain elusive. The goal present study was elucidate mechanism by which LINC02282, a significantly downregulated lncRNA in GEO database, elicits neuroprotective effects on PD. LINC02282 poorly expressed SH-SY5Y SK-N-AS cells exposed MPP+ mice injected with MPTP. overexpression plasmids inhibited apoptosis promoted proliferation cells. In addition, using an adeno-associated virus reduced neuronal damage PD mice. mainly localized nucleus, methylation tripartite motif-containing protein 6 (TRIM6) promoter inhibit TRIM6 expression. bound DNA methyltransferases (DNMTs) increases binding DNMTs promoter. Overexpression alone induced PD-like symptoms combined upregulation effect both vitro vivo. summary, alleviated injury recruiting region inhibiting

Language: Английский

Citations

2
Synucleins: New Data on Misfolding, Aggregation and Role in Diseases DOI Creative Commons
Andrei Surguchov,

Alexei Surguchev

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3241 - 3241

Published: Dec. 13, 2022

The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins consisting α-, β-, and γ-synuclein involved in neurodegenerative diseases cancer. current number publications on has exceeded 16.000. They remain the subject constant interest for over 35 years. Two reasons explain this unchanging attention: synuclein's association with several severe human lack understanding functional roles under normal physiological conditions. We analyzed recent to look at main trends developments synuclein research discuss possible future directions. Traditional areas peak which still high among last year's comparative studies structural features as well three members family. Another popular topic area is mechanism α-synuclein accumulation, aggregation, fibrillation. Exciting fast-growing epigenetics. do not present here broad comprehensive review all directions but summarize only most significant findings relevant these topics outline potential

Language: Английский

Citations

46
Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease DOI Creative Commons
Maria Tsalenchuk, Steve Gentleman, Sarah J. Marzi

et al.

npj Parkinson s Disease, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 25, 2023

Abstract Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology unknown. Environmental factors, including pesticides, have been reported increase of developing disease. Growing evidence suggests epigenetic changes are key mechanisms which these factors act upon gene regulation, in disease-relevant cell types. We present systematic review critically appraising summarising current body relationship PD inform future research this area. Epigenetic studies relevant animal models yielded promising results, however, humans just emerging. While published currently relatively limited, importance field for elucidation molecular pathogenesis opens clear avenues research. Carefully designed epidemiological carried out patients hold great potential uncover regulatory mechanisms. Therefore, advance burgeoning field, we recommend broadening scope investigations include more increasing sample sizes, focusing on types, recruiting diverse cohorts.

Language: Английский

Citations

35
Defining Parkinson’s Disease: Past and Future DOI Creative Commons
Kristína Kulcsarová, Matěj Škorvánek,

Ronald B. Postuma

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(s2), P. S257 - S271

Published: March 15, 2024

Parkinson’s disease (PD) is the second most common still relentlessly progressive neurodegenerative disorder with a long period in which pathophysiological process already spreading but cardinal motor symptoms are not present. This review outlines major developments and milestones our understanding of PD that have shaped way we define this disorder. Past criteria definitions been based on clinical manifestations enabling diagnosis only later symptomatic stages. Nevertheless, advancing knowledge pathophysiology aim early detection, shift diagnostic paradigm being advocated towards biological definition similar to other disorders including Alzheimer’s Huntington’s disease, ultimate goal an earlier, course modifying therapy. We summarize pillars possible approach vivo detection neuronal α-synuclein aggregation, neurodegeneration genetics outline their application different contexts use frame definition.

Language: Английский

Citations

13
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Creative Commons
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474

Published: March 7, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.

Language: Английский

Citations

11
The rise of Parkinson’s disease is a global challenge, but efforts to tackle this must begin at a national level: a protocol for national digital screening and “eat, move, sleep” lifestyle interventions to prevent or slow the rise of non-communicable diseases in Thailand DOI Creative Commons
Roongroj Bhidayasiri, Jirada Sringean, Saisamorn Phumphid

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

The rising prevalence of Parkinson’s disease (PD) globally presents a significant public health challenge for national healthcare systems, particularly in low-to-middle income countries, such as Thailand, which may have insufficient resources to meet these escalating needs. There are also many undiagnosed cases early-stage PD, period when therapeutic interventions would the most value and least cost. traditional “passive” approach, whereby clinicians wait patients with symptomatic PD seek treatment, is inadequate. Proactive, early identification will allow timely interventions, digital technologies can be scaled up diagnosis cases. risk survey (TCTR20231025005) aims evaluate population screening platform identify Thai population. Recognizing long prodromal phase target demographic people aged ≥ 40 years, approximately 20 years before usual emergence motor symptoms. Thailand has highly rated system an established universal program citizens, making it ideal deploying using technology. Designed by multidisciplinary group experts, comprises 20-item questionnaire about symptoms along objective tests eight markers: voice vowel, sentences, resting postural tremor, alternate finger tapping, “pinch-to-size” test, gait balance, performance recorded mobile application smartphone’s sensors. Machine learning tools use collected data subjects at developing, or signs of, PD. This article describes selection validation items markers, results showing chosen parameters analysis methods robust, reliable, reproducible. could serve model similar strategies other non-communicable diseases Thailand.

Language: Английский

Citations

11
DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome DOI Creative Commons
Samantha L. Schaffner, Michael S. Kobor

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 19, 2022

Parkinson’s disease (PD) is a neurodegenerative disorder with complex etiology and increasing prevalence worldwide. As PD influenced by combination of genetic environment/lifestyle factors in approximately 90% cases, there interest identification the interindividual mechanisms underlying development as well actionable lifestyle that can influence risk. This narrative review presents an outline environmental contributing to risk explores possible roles cytosine methylation hydroxymethylation and/or early-stage biomarkers PD, emphasis on epigenome-wide association studies (EWAS) conducted over past decade. Specifically, we focused variants SNCA gene, exposure pesticides, physical activity key contributors Current research indicates these individually impact epigenome, particularly at level CpG methylation. There also emerging evidence for interaction effects between contributions risk, possibly acting across multiple omics layers. We speculated this may be one reason poor replicability results EWAS reported date. Our goal provide direction future epigenetics build upon existing foundations leverage large datasets, new technologies, relevant statistical approaches further elucidate disease.

Language: Английский

Citations

29