
Neuroscience Research, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Neuroscience Research, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Prostaglandins & Other Lipid Mediators, Journal Year: 2023, Volume and Issue: 166, P. 106718 - 106718
Published: Feb. 21, 2023
Language: Английский
Citations
27Cell Stress, Journal Year: 2024, Volume and Issue: 8, P. 21 - 50
Published: Jan. 1, 2024
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features spatial compartmentalization (integrity barriers, containment local perturbations), maintenance homeostasis over time (recycling & turnover, integration circuitries, rhythmic oscillations) and an array adequate responses to stress (homeostatic resilience, hormetic regulation, repair regeneration). These affect all somatic strata the human body (molecules, organelles, cells, supracellular units, organs, organ systems, systemic circuitries meta-organism). Here postulate mental socioeconomic factors must be added this 8×8 matrix as additional hallmark (“psychosocial adaptation”) stratum interactions”), hence building a 9×9 matrix. Potentially, perturbation each affects psychosocial vice versa. Finally, discuss (patho)physiological bases these interactions their implications for improvement.
Language: Английский
Citations
7International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2821 - 2821
Published: Feb. 1, 2023
Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population recent prospective studies have confirmed this link. Breakthroughs in our understanding of diseases underlying LUTS shown many substantial inflammatory component great strides been made recently how inflammation is triggered. Meanwhile, on disorders found are associated central neuroinflammation, most notably hippocampus. Excitingly, work other characterized by peripheral they can trigger neuroinflammation disorders. In review, we discuss current tying to its possible bidirectionally, common mechanism. We also review modern theories depression. Finally, exciting new animal directly tie two bladder conditions extensive (cyclophosphamide-induced hemorrhagic cystitis outlet obstruction) conclude discussion mechanisms which translated into resulting psychiatric concerns.
Language: Английский
Citations
17Neurotherapeutics, Journal Year: 2023, Volume and Issue: 20(2), P. 484 - 501
Published: Jan. 9, 2023
Language: Английский
Citations
10Matter, Journal Year: 2024, Volume and Issue: 7(11), P. 3811 - 3844
Published: Nov. 1, 2024
Language: Английский
Citations
4Nöro Psikiyatri Arşivi, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Bipolar disorder (BD) is a chronic associated with significant psychiatric morbidity and disability. Recent research has linked inflammatory processes to the pathology of BD. Resolvin D1 (RvD1), an anti-inflammatory molecule derived from eicosapentaenoic acid (EPA) docosahexaenoic (DHA), been shown inhibit apoptosis neuroinflammation, promote neurogenesis. This study aims determine changes in serum RvD1 levels between acute episode euthymic periods patients BD their association metabolic syndrome (MetS) parameters. prospective clinical was conducted diagnosed BD-I according SCID-5. Patients whose were assessed during manic depressive episodes previous invited return after at least 8 weeks, when they had reached period. Blood samples for RvD1, C-reactive protein (CRP), hemogram tests collected both remission periods. The included 32 episodes, 27 41 healthy controls, no age difference among groups. decreased significantly complete period (p=0.017, z=-2.391) follow-up. decrease depression not statistically significant. Serum remained high control group (p=0.581, z=-0.553). During follow-up period, white blood cell (p=0.009, z=-2.606) neutrophil (p=0.007, z=-2.693) mania CRP values (p=0.004, z=-2.880) found have statistically. indicates that are elevated compared controls episode. We propose potential utility as diagnostic marker identifying states. can assume there process which also plays role. Further needed explore therapeutic targeting pathways treatment.
Language: Английский
Citations
0Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(4), P. 223 - 223
Published: April 15, 2023
The implantation of a biomaterial will lead to the immediate onset an acute inflammatory response, which is key importance in shaping quality repair process. However, return homeostasis critical prevent chronic response that may impair healing resolution now recognized as active and highly regulated process, being described specialized immunoresolvents have fundamental role termination response. These mediators collectively coined pro-resolving (SPMs) are family endogenous molecules include lipoxins (Lx), resolvins (Rv), protectins (PD), maresins (Mar), Cysteinyl-SPMs (Cys-SPMs) n-3 docosapentaenoic acid-derived SPMs (n-3 DPA-derived SPMs). important anti-inflammatory pro-resolutive actions such decreasing recruitment polymorphonuclear leukocytes (PMNs), inducing macrophages, increasing macrophage clearance apoptotic cells through process known efferocytosis. Over last years, trend biomaterials research has shifted towards engineering materials able modulate thus stimulate appropriate immune responses, so-called immunomodulatory biomaterials. should be host with aim creating pro-regenerative microenvironment. In this review, we explore potential using development new propose insights for future field.
Language: Английский
Citations
6Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 154(4), P. 279 - 293
Published: Feb. 15, 2024
Despite the importance of lipid mediators in stress and depression their link to inflammation, influence on these role inflammation is not fully understood. This study used RNA-seq, LC-MS/MS, flow cytometry analyses a mouse model subjected chronic social defeat explore effects acute mediators, gene expression, cell population bone marrow spleen. In marrow, induced sustained transition from lymphoid myeloid cells, accompanied by corresponding changes expression. change was associated with decreased levels 15-deoxy-d12,14-prostaglandin J2, mediator that inhibits inflammation. spleen, also lymphoid-to-myeloid transition, albeit transiently, alongside expression indicative extramedullary hematopoiesis. These were linked lower 12-HEPE resolvins, both critical for inhibiting resolving Our findings highlight significant anti-inflammatory pro-resolving immune responses paves way understanding how contribute mechanisms depression.
Language: Английский
Citations
2Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 156(2), P. 82 - 85
Published: July 30, 2024
Neohesperidin, a citrus flavonoid, shows potential for activating the mechanistic target of rapamycin complex 1 (mTORC1). Here, antidepressant-like effect neohesperidin was examined in male ICR mice (naïve and treated repeatedly with prednisolone, synthetic glucocorticoid, which induces depression-like behavior). Oral administration exerted an forced swim test h post-treatment, naïve mice; this no longer observed at 24 h. Neohesperidin also reversed prednisolone-induced behavior. This blocked by infusing rapamycin, mTORC1 inhibitor, into medial prefrontal cortex. may rapidly produce effect.
Language: Английский
Citations
2Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(8), P. 795 - 808
Published: Sept. 13, 2023
Ketamine, an
Language: Английский
Citations
2