Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration

Prostaglandins & Other Lipid Mediators, Journal Year: 2023, Volume and Issue: 166, P. 106718 - 106718

Published: Feb. 21, 2023

Language: Английский

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The missing hallmark of health: psychosocial adaptation

Cell Stress, Journal Year: 2024, Volume and Issue: 8, P. 21 - 50

Published: Jan. 1, 2024

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features spatial compartmentalization (integrity barriers, containment local perturbations), maintenance homeostasis over time (recycling & turnover, integration circuitries, rhythmic oscillations) and an array adequate responses to stress (homeostatic resilience, hormetic regulation, repair regeneration). These affect all somatic strata the human body (molecules, organelles, cells, supracellular units, organs, organ systems, systemic circuitries meta-organism). Here postulate mental socioeconomic factors must be added this 8×8 matrix as additional hallmark (“psychosocial adaptation”) stratum interactions”), hence building a 9×9 matrix. Potentially, perturbation each affects psychosocial vice versa. Finally, discuss (patho)physiological bases these interactions their implications for improvement.

Language: Английский

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Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2821 - 2821

Published: Feb. 1, 2023

Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population recent prospective studies have confirmed this link. Breakthroughs in our understanding of diseases underlying LUTS shown many substantial inflammatory component great strides been made recently how inflammation is triggered. Meanwhile, on disorders found are associated central neuroinflammation, most notably hippocampus. Excitingly, work other characterized by peripheral they can trigger neuroinflammation disorders. In review, we discuss current tying to its possible bidirectionally, common mechanism. We also review modern theories depression. Finally, exciting new animal directly tie two bladder conditions extensive (cyclophosphamide-induced hemorrhagic cystitis outlet obstruction) conclude discussion mechanisms which translated into resulting psychiatric concerns.

Language: Английский

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Intranasal Administration of Resolvin E1 Produces Antidepressant-Like Effects via BDNF/VEGF-mTORC1 Signaling in the Medial Prefrontal Cortex

Neurotherapeutics, Journal Year: 2023, Volume and Issue: 20(2), P. 484 - 501

Published: Jan. 9, 2023

Language: Английский

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Innate immunity-modulating nanobiomaterials for controlling inflammation resolution

Matter, Journal Year: 2024, Volume and Issue: 7(11), P. 3811 - 3844

Published: Nov. 1, 2024

Language: Английский

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May Resolvin D1 Represent Axonal Damage as Well as Chronic Inflammation in Bipolar Disorder?

Nöro Psikiyatri Arşivi, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Bipolar disorder (BD) is a chronic associated with significant psychiatric morbidity and disability. Recent research has linked inflammatory processes to the pathology of BD. Resolvin D1 (RvD1), an anti-inflammatory molecule derived from eicosapentaenoic acid (EPA) docosahexaenoic (DHA), been shown inhibit apoptosis neuroinflammation, promote neurogenesis. This study aims determine changes in serum RvD1 levels between acute episode euthymic periods patients BD their association metabolic syndrome (MetS) parameters. prospective clinical was conducted diagnosed BD-I according SCID-5. Patients whose were assessed during manic depressive episodes previous invited return after at least 8 weeks, when they had reached period. Blood samples for RvD1, C-reactive protein (CRP), hemogram tests collected both remission periods. The included 32 episodes, 27 41 healthy controls, no age difference among groups. decreased significantly complete period (p=0.017, z=-2.391) follow-up. decrease depression not statistically significant. Serum remained high control group (p=0.581, z=-0.553). During follow-up period, white blood cell (p=0.009, z=-2.606) neutrophil (p=0.007, z=-2.693) mania CRP values (p=0.004, z=-2.880) found have statistically. indicates that are elevated compared controls episode. We propose potential utility as diagnostic marker identifying states. can assume there process which also plays role. Further needed explore therapeutic targeting pathways treatment.

Language: Английский

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The Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(4), P. 223 - 223

Published: April 15, 2023

The implantation of a biomaterial will lead to the immediate onset an acute inflammatory response, which is key importance in shaping quality repair process. However, return homeostasis critical prevent chronic response that may impair healing resolution now recognized as active and highly regulated process, being described specialized immunoresolvents have fundamental role termination response. These mediators collectively coined pro-resolving (SPMs) are family endogenous molecules include lipoxins (Lx), resolvins (Rv), protectins (PD), maresins (Mar), Cysteinyl-SPMs (Cys-SPMs) n-3 docosapentaenoic acid-derived SPMs (n-3 DPA-derived SPMs). important anti-inflammatory pro-resolutive actions such decreasing recruitment polymorphonuclear leukocytes (PMNs), inducing macrophages, increasing macrophage clearance apoptotic cells through process known efferocytosis. Over last years, trend biomaterials research has shifted towards engineering materials able modulate thus stimulate appropriate immune responses, so-called immunomodulatory biomaterials. should be host with aim creating pro-regenerative microenvironment. In this review, we explore potential using development new propose insights for future field.

Language: Английский

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Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen

Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 154(4), P. 279 - 293

Published: Feb. 15, 2024

Despite the importance of lipid mediators in stress and depression their link to inflammation, influence on these role inflammation is not fully understood. This study used RNA-seq, LC-MS/MS, flow cytometry analyses a mouse model subjected chronic social defeat explore effects acute mediators, gene expression, cell population bone marrow spleen. In marrow, induced sustained transition from lymphoid myeloid cells, accompanied by corresponding changes expression. change was associated with decreased levels 15-deoxy-d12,14-prostaglandin J2, mediator that inhibits inflammation. spleen, also lymphoid-to-myeloid transition, albeit transiently, alongside expression indicative extramedullary hematopoiesis. These were linked lower 12-HEPE resolvins, both critical for inhibiting resolving Our findings highlight significant anti-inflammatory pro-resolving immune responses paves way understanding how contribute mechanisms depression.

Language: Английский

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Neohesperidin exerts antidepressant-like effect via the mechanistic target of rapamycin complex 1 in the medial prefrontal cortex in male mice

Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 156(2), P. 82 - 85

Published: July 30, 2024

Neohesperidin, a citrus flavonoid, shows potential for activating the mechanistic target of rapamycin complex 1 (mTORC1). Here, antidepressant-like effect neohesperidin was examined in male ICR mice (naïve and treated repeatedly with prednisolone, synthetic glucocorticoid, which induces depression-like behavior). Oral administration exerted an forced swim test h post-treatment, naïve mice; this no longer observed at 24 h. Neohesperidin also reversed prednisolone-induced behavior. This blocked by infusing rapamycin, mTORC1 inhibitor, into medial prefrontal cortex. may rapidly produce effect.

Language: Английский

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Antidepressant-like effects of tomatidine and tomatine, steroidal alkaloids from unripe tomatoes, via activation of mTORC1 in the medial prefrontal cortex in lipopolysaccharide-induced depression model mice

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(8), P. 795 - 808

Published: Sept. 13, 2023

Ketamine, an

Language: Английский

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