Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment DOI Creative Commons
Laura Mussalo, Simone Avesani, Muhammad Ali Shahbaz

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167038 - 167038

Published: Sept. 13, 2023

Ultrafine particles (UFP) with a diameter of ≤0.1 μm, are contributors to ambient air pollution and derived mainly from traffic emissions, yet their health effects remain poorly characterized. The olfactory mucosa (OM) is located at the rooftop nasal cavity directly exposed both environment brain. Mounting evidence suggests that pollutant affect brain through tract, however, exact cellular mechanisms how OM responds pollutants known. Here we show responses primary human cells altered upon exposure UFPs different fuels engines elicit adverse effects. We used collected exhausts heavy-duty-engine run renewable diesel (A0) fossil (A20), modern vehicle (Euro6) compared on by assessing processes functional transcriptomic levels. Quantification revealed all samples as majority being μm an aerodynamic diameter. Exposure A0 A20 induced substantial alterations in associated inflammatory response, xenobiotic metabolism, signaling, epithelial integrity. Euro6 caused only negligible changes, demonstrating efficacy aftertreatment devices. Furthermore, when A20, elicited less pronounced cells, suggesting induces cells. Prior studies these results suggest PAHs may disturb process metabolism might mediate harmful route. This study provides important information human-based vitro model, therefore providing new insight form basis for mitigation preventive actions against possible toxicological impairments UFP exposure.

Language: Английский

Short-term exposure to PM2.5 and high pollution events on depressive symptoms among adolescents DOI
Fei Wang,

Xinyao Lian,

Yaqi Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138131 - 138131

Published: April 1, 2025

Language: Английский

Citations

1
Execution and emission characteristics of automotive compression ignition engine powered by cerium oxide nanoparticles doped water diesel emulsion fuel DOI
Sujeet Kesharvani, Mayank Chhabra, Gaurav Dwivedi

et al.

Fuel, Journal Year: 2023, Volume and Issue: 349, P. 128670 - 128670

Published: May 18, 2023

Language: Английский

Citations

20
Mood Disorders: The Gut Bacteriome and Beyond DOI Creative Commons
Amelia J. McGuinness, Amy Loughman, Jane A. Foster

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(4), P. 319 - 328

Published: Sept. 3, 2023

Knowledge of the microbiome-gut-brain axis has revolutionized field psychiatry. It is now well recognized that gut bacteriome associated with, and likely influences, pathogenesis mental disorders, including major depressive disorder bipolar disorder. However, whilst substantial advances in microbiome science have been made, we only scratched surface our understanding how these ecosystems might contribute to pathophysiology. Beyond bacteriome, research into lesser explored components microbiome, virome, mycobiome, archaeome, parasitome, increasingly suggesting relevance The contribution microbiomes beyond gut, oral, lung, small intestinal microbiomes, human health pathology should not be overlooked. Increasing both awareness less traversed fields critical improving therapeutic benefits treatments targeting fecal transplantation, postbiotics biogenics, dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required fully elucidate different microbial distinct niches interact with each other their hosts. Excitingly, may at start next revolution, thus one step closer informing precision psychiatry improve outcomes for those living illness.

Language: Английский

Citations

17
Effect of water-emulsive biodiesel/diesel blend with alumina nanoparticles on diesel engine performance and emissions: experiments and optimization DOI

Mohamed E. Khidr,

Hamdy Hassan, Tamer F. Megahed

et al.

Process Safety and Environmental Protection, Journal Year: 2024, Volume and Issue: 186, P. 10 - 24

Published: April 3, 2024

Language: Английский

Citations

7
Affective disorder and brain alterations in children and adolescents exposed to outdoor air pollution DOI
Hongsheng Xie, Yuan Cao, Jiafeng Li

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 331, P. 413 - 424

Published: March 28, 2023

Language: Английский

Citations

17
Are actual and perceived environmental conditions associated with variation in mental health? DOI Creative Commons
Sarah Gomm, Thomas Bernauer

Environmental Research, Journal Year: 2023, Volume and Issue: 223, P. 115398 - 115398

Published: Feb. 3, 2023

Empirical evidence on the relationship between environmental factors and mental health remains inconclusive. One reason is that there only scant association subjective exposure to stressors, relative objective pollution. We thus focus how perceived actual presence of noise, air pollution, green spaces relates health. Our cross-sectional study based a large representative sample adult population in Switzerland (n = 5729). Using individual-level geocodes subjects' residence, we combined data from survey these individuals with objectively measured longer-term conditions (noise, spaces). Subclinical was assessed 12-item General Health Questionnaire (GHQ-12). When fitting multiple regressions mediation models, find perceptions stressors are better predictor distress than stressors. In addition, predictive power nature visits stronger mere proximity at place residence. found no direct link health, but via Further, frequency mediated by perceived, not Since as equally burdensome all people, their perception crucial when evaluating policy interventions aimed improving Even relatively low level classified non-harmful human physical or biological sense, may contribute negative outcomes. The main implication attractive accessible provide an enhanced sense control over thereby reduce impacts.

Language: Английский

Citations

16
Particulate Matter Exposure and Its Consequences on Hippocampal Neurogenesis and Cognitive Function in Experimental Models DOI Creative Commons

Charu Jaiswal,

Abhishek Kumar Singh

Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125275 - 125275

Published: Nov. 7, 2024

Exposure to air pollution is thought cause millions of deaths globally each year. According the Who 2018, approximately 7 million annually are caused predominantly by noncommunicable diseases due pollution. particulate matter 2.5 (PM2.5) has been strongly associated with increased mortality and significant effects on brain health. Air pollution, particularly ultrafine matter, emerged as a serious environmental concern profound implications for human Studies in animal models have indicated that exposure these pollutants during gestational development impacts prenatal postnatal development. In particular, increasingly identified potential causative factor, it affects neurogenesis brain's hippocampal region. The hippocampus highly vulnerable PM exposure, any alteration structure or function this region leads various neurodevelopmental defects neurodegenerative disorders via oxidative stress, microglial activation, neuronal death, differential expression genes. process involves several steps, such proliferation, differentiation, migration, synaptogenesis, neuritogenesis. If step hampered other factors, can lead defects, disorders, cognitive decline. One contributor alterations which ranks leading risk factor worldwide. Some most common include neuroinflammation, depressive behavior, altered processes, activation. This review explores how regions exposure.

Language: Английский

Citations

6
Air pollution and age-dependent changes in emotional behavior across early adolescence in the U.S. DOI Creative Commons
Claire Campbell, Devyn L. Cotter, Katherine L. Bottenhorn

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 240, P. 117390 - 117390

Published: Oct. 21, 2023

Language: Английский

Citations

12
Associations of Indoor Ventilation Frequency with Depression and Anxiety in Chinese Older Adults DOI Creative Commons
Jing Du,

Yan Cui,

Ling Yang

et al.

Indoor Air, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 11

Published: Feb. 20, 2024

Depression and anxiety carry an important public health burden. Indoor air pollution is associated with depression anxiety. Ventilation can reduce the concentration of indoor improve quality. This study explored relationship between ventilation frequency in older adults using data from 2018 Chinese Longitudinal Healthy Longevity Survey. Compared people low frequency, those high had 51% lower odds ( OR=0.49 , 95% CI: 0.43 to 0.57) 37% id="M2">OR=0.63 0.91), intermediate 35% id="M3">OR=0.65 0.56 0.75) 45% id="M4">OR=0.55 0.37 0.82). The results were similar across seasons. However, there sex, age, lifestyle, cooking fuel use-specific differences these associations. findings emphasize that may be conducive improving mental adults, especially women, old elder, nonsmokers, nondrinkers, who do not exercise cooked at home.

Language: Английский

Citations

5
The impact of indoor air pollution on children’s health and well-being: the experts’ consensus DOI Creative Commons
Elena Bozzola, Rino Agostiniani,

Laura Pacifici Noja

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2024, Volume and Issue: 50(1)

Published: April 14, 2024

Abstract Background Pollution of the indoor environment represents a concern for human health, mainly in case prolonged exposure such as women, children, elderly, and chronically ill, who spend most their time closed environments. Main body The aim study is to organize group experts order evaluate evidence discuss main risk factors concerning air impact on health well challenging regarding preventive strategies reduce pollution. highlighted air, including poor ventilation, climatic conditions, chemical substances, socio-economic status. They discussed terms mortality morbidity, Conclusion identified that can be reinforced pollution prevent negative consequences at national local levels.

Language: Английский

Citations

4