Functional integration and segregation during semantic cognition: Evidence across age groups DOI Creative Commons
Wei Wu, Paul Hoffman

Cortex, Journal Year: 2024, Volume and Issue: 178, P. 157 - 173

Published: July 9, 2024

Semantic cognition is underpinned by ventral anterior temporal lobe (vATL) which encodes knowledge representations and inferior frontal gyrus (IFG), controls activation of based on the needs current context. This core semantic network has been validated in substantial empirical findings past. However, it remains unclear how these areas dynamically communicate with each other, other neural networks, to achieve successful processing. Here, we investigated this question testing functional connectivity during tasks whether connections were affected cognitive ageing. Compared a non-semantic task, increased between left right IFGs, indicating bilateral control system. Strengthened was also found IFG vATL, effect stronger young group. At whole-brain scale, vATL their coupling multiple-demand regions tasks, even though deactivated relative tasks. suggests that domain-general executive contributes In contrast, decreased interaction default mode (DMN) positively activated task. DMN do not contribute all tasks: may sometimes reflect automatic retrieval task-irrelevant memories associations. Taken together, our study characterizes dynamic mechanism supporting within beyond regions.

Language: Английский

Modeling the neurocognitive dynamics of language across the lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 29, 2024

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting‐state fMRI neuropsychological data from 628 healthy adults (age 18–88) the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter‐cognitive synergy semantic domain‐general processes. cerebral show default mode network (DMN) suppression coupled fronto‐parietal (FPN) integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age‐related in LP. Relatedly, reduced DMN midlife could compromise ability manage cost FPN integration. This may prompt older adopt more cost‐efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel synergistic, economical, nonlinear, emergent, model, integrating connectomic dimensions within complex system perspective.

Language: Английский

Citations

4
When Maturation is Not Linear: Brain Oscillatory Activity in the Process of Aging as Measured by Electrophysiology DOI
Sandra Doval, David López‐Sanz, Ricardo Bruña

et al.

Brain Topography, Journal Year: 2024, Volume and Issue: 37(6), P. 1068 - 1088

Published: June 20, 2024

Language: Английский

Citations

4
Linguistic inputs must be syntactically parsable to fully engage the language network DOI Creative Commons
Carina Kauf,

Hee So Kim,

Elizabeth J. Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Abstract Human language comprehension is remarkably robust to ill-formed inputs (e.g., word transpositions). This robustness has led some argue that syntactic parsing largely an illusion, and incremental more heuristic, shallow, semantics-based than often assumed. However, the available data are also consistent with possibility humans always perform rule-like symbolic simply deploy error correction mechanisms reconstruct when needed. We put these hypotheses a new stringent test by examining brain responses a) stimuli should pose challenge for reconstruction but allow complex meanings be built within local contexts through associative/shallow processing (sentences presented in backward order), b) grammatically well-formed semantically implausible sentences impede heuristic processing. Using novel behavioral paradigm, we demonstrate backward- indeed recovery of grammatical structure during comprehension. Critically, backward-presented elicit relatively low response areas, as measured fMRI. In contrast, areas similar magnitude naturalistic (plausible) sentences. other words, ability build structures both necessary sufficient fully engage network. Taken together, results provide strongest date support generalized reliance human on parsing. Significance statement Whether relies predominantly structural (syntactic) cues or meaning- related (semantic) remains debated. shed light this question areas’ where semantic pitted against each other, using find respond weakly composition cannot parsed syntactically—as confirmed paradigm—and they strongly sentences, like famous ‘Colorless green ideas sleep furiously’ sentence. These findings accounts suggest can foregone favor shallow

Language: Английский

Citations

4
Older adults produce more verbal false memories than younger adults: is it semantics or executive functioning? DOI Creative Commons
Martina Cangelosi, Luca Rinaldi, Ton Dijkstra

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 17, 2025

Abstract Background A verbal false memory occurs when one remembers a word (called “critical lure”) as part of previously presented list despite its absence. This phenomenon may be linked to the semantic associations critical lure with actual items. Aims We aimed investigate mechanisms behind increase in memories aging, evaluating whether this is due greater reliance on processing or impaired executive functioning. Methods employed Deese-Roediger-McDermott (DRM) paradigm, presenting DRM lists two age groups: young adults and older adults. In addition, participants completed Hayling Sentence Completion Test assess inhibition Backward Digit Span Task evaluate working memory. Results Our findings confirm that experience more than younger participants. suggest both impairment contribute while was not significantly related production. Discussion Older adults’ increased susceptibility appears arise from an interplay between enhanced deficits. Conclusions study proposes novel integration underlying observed during playing unexpected role enhancing susceptibility.

Language: Английский

Citations

0
Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging DOI
Maggie P. Rempe,

Danae S Manta,

Kenneth J. Cohen

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Representation of event and object concepts in ventral anterior temporal lobe and angular gyrus DOI Creative Commons
Yueyang Zhang, Wei Wu, Daniel Mirman

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(2)

Published: Jan. 6, 2024

Abstract Semantic knowledge includes understanding of objects and their features also the characteristics events. The hub-and-spoke theory holds that these conceptual representations rely on multiple information sources are integrated in a central hub ventral anterior temporal lobes. dual-hub expands this framework with claim lobe is specialized for object representation, while second angular gyrus event representation. To test ideas, we used representational similarity analysis, univariate psychophysiological interaction analyses fMRI data collected participants processed concepts (e.g. “an apple,” “a wedding”) presented as images written words. Representational analysis showed encoded concept more than similarity, although left similarity. Bilateral lobes both structure, exhibited stronger coding Psychophysiological revealed greater connectivity between right pMTG, bilateral ITG middle occipital gyrus, compared to concepts. These findings support specialization semantics, though some involvement coding, but do not

Language: Английский

Citations

3
Dynamics of White Matter Architecture in Lexical Production among Middle-Aged Adults DOI Creative Commons
Clément Guichet, Élise Roger, Arnaud Attyé

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

Abstract This study aimed to elucidate the white matter changes associated with lexical production (LP) difficulties that typically emerge in middle age, resulting increased naming latencies. To delay onset of LP decline, middle-aged adults may rely on domain-general (DG) and language-specific (LS) compensatory mechanisms as proposed by LARA model (Lexical Access Retrieval Aging). However, our knowledge supporting these remains incomplete. Based a sample 155 from CAMCAN cohort, we combined dimensionality reduction techniques multivariate statistical methods jointly examine relationships between diffusion-weighted imaging LP-related neuropsychological data. Our findings (i) show midlife constitutes pivotal period marked discontinuity brain structure within distributed networks dorsal, ventral, anterior cortico-subcortical pathways, (ii) reveal this signals neurocognitive transition around age 53-54, marking decline. Indeed, results propose initially adopt “semantic strategy” compensate for initial challenges. Still, strategy be compromised when late (age 55-60) lose ability exert cognitive control over semantic representations (i.e., reduced control). In summary, advances comprehension underpin profile age. Specifically, underscore importance considering interplay DG LS processes studying trajectory performance healthy aging. Furthermore, offer valuable insights into identifying predictive biomarkers related dynamics observed midlife, which can help understand language-related neurodegenerative pathologies. Highlights Midlife characterized structure. Early 45-55) facilitate access sustain performances. Late gradually representations,

Language: Английский

Citations

1
Verbal semantic expertise is associated with reduced functional connectivity between left and right anterior temporal lobes DOI Open Access
Wei Wu, Paul Hoffman

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

Abstract The left and right anterior temporal lobes (ATLs) encode semantic representations. They show graded hemispheric specialisation in function, with the ATL contributing preferentially to verbal processing. We investigated underlying causes of this organisation, using resting-state functional connectivity as a measure segregation between ATLs. analysed two independent fMRI datasets (N=86 N=642) which participants’ expertise was measured vocabulary tests. In both datasets, people more advanced knowledge showed weaker ventral This effect highly specific. It not observed for within-hemisphere connections regions (ventral inferior frontal gyrus; IFG, though it found left-right IFG one dataset). Effects were tasks probing control, non-semantic cognition or face recognition. Our results suggest that ATLs is an innate property but rather emerges develop detailed propose consequence ATL’s greater left-lateralised written word recognition regions, represent meaning acquired primarily through reading.

Language: Английский

Citations

0
Midlife Dynamics of White Matter Architecture in Lexical Production DOI Creative Commons
Clément Guichet, Élise Roger, Arnaud Attyé

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 144, P. 138 - 152

Published: Sept. 28, 2024

Language: Английский

Citations

0
Modeling the Neurocognitive Dynamics of Language across the Lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 4, 2023

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting-state fMRI neuropsychological data from 628 healthy adults (age 18-88) the CamCAN cohort, we performed state-of-the-art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter-cognitive synergy semantic domain-general processes. cerebral show DMN (Default Mode Network) suppression coupled FPN (Fronto-Parietal integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age-related in LP. Relatedly, reduced midlife could compromise ability manage cost integration. This may prompt older adopt more cost-efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel SENECA model (Synergistic, Economical, Nonlinear, Emergent, Cognitive Aging), integrating connectomic dimensions within complex system perspective. Highlights Lexical ( ) relies on interplay processes life. Default Network cooperates Fronto-Parietal maintain performance cost. Midlife marks shift, prompting prioritizes performance.

Language: Английский

Citations

1